Thirty Years of HIV/AIDS;Science and Leadership

Carl W. Dieffenbach, Ph.D.Director, Division of AIDS,

NIAID, NIHAugust 14, 2011

HIV Incidence Reduction by Prevention Technologies

0 10 20 30 40 50 60 70 80 90 100Efficacy (%)

Study Effect Size (95% CI)

ARV treatment for prevention

PrEP for discordant couples

PrEP for heterosexual men & women

Medical male circumcision

PrEP for MSMs

Sexually transmitted diseases treatment

Microbicide

FEM-PrEP

HIV vaccine

96% (73-99)

73% (49-85)

63% (21-84)

54% (38-66)

44% (15-63)

42% (21-58)

39% (6-60)

0% (0-41)

31% (1-51)

Reducing HIV incidence

Increasing access to care and optimizing health outcomes

Reducing HIV-related health disparities