1

Pharmaceutical Challenges for the Semantic Web

2

Elements of Successful Drug Discovery

Safety

Efficacy

Cost Effectiveness

Timeliness

3

What Modern Drug Discovery Needs to Contend with

Qualified Targets

Lead Generation

Toxicity & Safety

Biomarkers

PharmacogenomicsClinical Trials

Molecular Mechanisms

Lead Optimization

4

5

New Regulatory Issues Confronting Pharmaceutics

“In response to the widening gap between basic biomedical knowledge and clinical application, governments and the academic community have undertaken a range of initiatives. After decades of investment in basic biomedical research, the focus is widening to include translational research — multidisciplinary scientific effortsdirected at "accelerating therapy development" (i.e., moving basic discoveries into the clinic more efficiently).”

from Innovation or Stagnation, FDA Report March 2004

6

Diversity of Meanings…

Genes Diseases

Proteins

Pathways

Splice Variants

Genotypes

Active Compounds

Systems and Models

Transcriptional Regulation

Genetics