(1 of 3) · hyperemia & congestion • edema • hemorrhage • hemostasis • hyperemia &...
TRANSCRIPT
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Hemodynamic disorders (1 of 3)
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What will we discuss today?
•Hyperemia & congestion
•Edema
•Hemorrhage
•Hemostasis
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Hyperemia & congestion
•Both = increase in blood volume within a tissue
Hyperemia Congestion
active passive
red blue-red
arterial venous
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Morphology
•Acute VS chronic pulmonary congestion
•Acute VS chronic hepatic congestion
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Edema, an introduction
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Edema
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Edema, clinical manifestations
•According to the tissue involved
•Can be life-threatening
•Examples………?
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Hemorrhage
= extravasation of blood from vessels
•Chronically congested tissues…capillary hemorrhages
•Hemorrhagic diathesis…susceptibility to bleed even with minor trauma
•Trauma, atherosclerosis, inflammation, or neoplasms can lead to hemorrhage
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Hemorrhage, cont’d
•External or internal
•From trivial (bruises) to fatal (large vessels such as aortic dissection)
•Large bleeds in body cavities…give some names..
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Hemorrhage, different sizes
• Petechiae…1-2mm
…skin, mucous membranes and serosal surfaces
…problems in platelets or vessel wall (e.g., vit. C deficiency)
• Purpura…3-5mm
…same causes of petechiae
…vasculitis is an important cause
• Echymoses…1-2cm
…subcutaneous
…= bruises
…hemoglobin bilirubin hemosiderin
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Hemorrhage consequences
•Hypovolemic shock
•Death
•Iron deficiency anemia
•No consequences
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Hemostasis
• A series of regulated processes that maintain blood in a fluid, clot-free state in normal vessels while rapidly forming a localized hemostatic plug at the site of vascular injury
• The pathologic counterpart of hemostasis is thrombosis
• 3 main players:
-vascular wall
-platelets
-coagulation cascade
The endothelium can have anticoagulant functions, and can be induced to activate coagulation due to triggers such as microbes, hemodynamic forces, and inflammatory mediators
By secreting tissue factor
Like TNF and IL-1
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Hemostasis, cont’d
= factor III = thromboplastin
also activates platelets
Degraded by adenosine diphosphatase produced by endothelial cells
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Hemostasis, cont’d
•Platelets bind via glycoprotein 1b (GpIb) receptors to von Willebrand factor (vWF) on exposed extracellular matrix (ECM)
…then they are activated shape change
granule release
…Released adenosine diphosphate (ADP) and thromboxane A2 (TxA2)
additional platelet aggregation through binding of platelet GpIIb-IIIa
receptors to fibrinogen
The primary hemostatic plug is now formed
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Hemostasis, cont’d
•Local activation of the coagulation cascade (involving tissue factor and platelet phospholipids)
fibrin polymerization
The secondary hemostatic plug is now formed
larger and more stable than the primary plug and contains entrapped red cells and leukocytes
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Homeostasis, cont’d
•t-PA (tissue plasminogen activator, a fibrinolytic product)
&
•thrombomodulin (interfering with the coagulation cascade)
are of the counter-regulatory mechanisms that limit the process to the site of injury
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Some inhibitors of coagulation
•Heparin-like molecules…on endothelial surface
…they are cofactors for the plasma protein
anti-thrombin III
•Thrombomodulin…change thrombin activity from cleaving fibrinogen
protein Cto cleaving and activating
•Tissue factor pathway inhibitor…inhibits tissue factor–factor VIIa
complex and factor Xa
Inhibits factor Va and factor VIIIa
protein S is a cofactor for it
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Abnormalities
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Coagulation cascade
We need phospholipid surface (by endothelium and platelets, and calcium ions
The ability of coagulation factors II, VII, IX, and X to bind to calcium requires vit. K
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Lab tests
• Prothrombin time (PT)…for activity
of proteins of extrinsic pathway
• Partial thromboplastin time (PTT)
…for activity of intrinsic pathway
proteins
-II -V -VII -X -Fibrinogen
-II -V -VIII -IX -X -XI -XII -fibrinogen
Can be used for monitoring heparin activity
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The fibrinolytic system
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