1 introduction lesson - reading 3-15

8/3/2019 1 Introduction Lesson - Reading 3-15

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Immunology


2/30

My name is ________ and Im a 48-

yr-old man with chronic renal failure.

About 8 days ago, I underwent

cadaveric renal transplant. Today I

was told I developed pathologically

elevated creatinine levels.


3/30

My name is ______ . Thing is, twenty-four

hours after placement of a catheter, I

developed fever and chills. Within 1 hour my

systolic blood pressure fell 30 points and I

developed swelling in my extremities and

severe edema in my lungs, as demonstrated

by chest x-ray. Despite valiant efforts by the

hospital staff, I died a few hours later.


4/30

My name is _______ and Im a 32-year-old

woman. I came to the emergency

department because ofsudden blindness.

They asked about my history, and I told

them about my right leg giving out from

time to time, causing me to have episodes

ofweakness and falling.

In this mornings MRI they pointed out

that I had periventricular plaques.


5/30

My name is _________ and Im 23 years

old. I came to my physician with a

bacterial infection. He asked me about

my history and I told him I have a history

of recurrent bacterial, fungal and viral

infections. My last blood test showed low

levels of all my immune cells.


6/30

My name is ________ and Im a 12-year-old

girl. I was brought to my pediatrician 3 monthsago by my mother because I had a fever. The

physician noticed I had features of albinism

and my mother stated that Ive always looked

this way. The physician diagnosed

staphylococcalinfection and gave meantibiotics.

Now, Im back with streptococcalinfection.

Apparently my medical records indicate that I

have had repeated bouts ofstaphylococcaland

streptococcalinfections for my entire life.


7/30

My name is _______ and Im 8 years old. I

have cystic fibrosis. Although I do everything

Im told to do by the grown-ups, my lungs

keep getting infected with bacteria. Im not

so much bothered by that, but more that theeffects of the infections are much stronger in

my case than other children.


8/30

My name is ________ and Im a clinical

researcher studying how to make vaccines

more effective. I just combined an

experimental vaccine, with Freunds

complete adjuvant. By this I obtained

enhanced vaccine potency.


9/30

My name is ________ and Im a 32-year-old man with Hodgkin's lymphoma. A

month ago I underwent bone marrow

transplantation, my brother was the donor.

After transplantation I was put on a

course ofimmunosuppressants and was

monitored for immune cell blood content,

with no apparent abnormal findings since.

This week, they found out that I have

developed an immune attack against my

own intestine.


10/30

My name is _______ and I dont know

how I ended up in Immunology class!


11/30

My name is ________ and Im a 12-

year old boy from Haifa. I live on anti-

allergy pills and if I ever forget to takethem, I really really really suffer.

In fact, it doesnt even help me if Itake the pills after an attack had begun.

We just moved to Arad and my life

improved greatly!


12/30

My name is _________ and Im Dr. Lewis post-doc

fellow. Despite Dr. Lewis plead, my family went on

vacation last year, we went to Thailand. My daughters

and son ran barefoot on the beach. They all came home

with this:

I will never go on

vacation again! Instead

I will work in Lewis lab

all day long!


13/30

My name is _________ and Im a bottle of powder

from smallpox lesions.


14/30

My name is _______ and I was just

evacuated from my home to a safe-house

because my husband hit me. I can still

describe the last slap in the face, it hurt

so bad! Turned red, swollen, immobile

and warm. But after a while it returned to

normal.


15/30


16/30

My name is ______ and Im a Neutrophil. Im

also nicknamed PMN (for polymorphonuclear).

When the kid with cystic fibrosis spoke I

remembered how each infection he had, Irushed out from the blood stream as I was

attractedto the inflamed area within minutes,

crossing many barriers on the way.

When I reached the damaged region, I spilled

my content and also swallowed the bacteria!


17/30

My name is _______ and Im a Macrophage. I dontroam the blood, I actually sit inside tissues as a resident

cell.

When I sense damage, I immediately turn very active

and start to spread the word to other cells around me,

causing damage, swallowing local elements and creating

a lot of injury.

I think my reputation should be rectified, ask me

why!


18/30

My name is _______ and Im a T cell.

My school is the thymus, thats where I learn to

become what I am and also have to promise not to

attack the body that I live in.

While I myself can identify a single antigen, my

friends and me altogether can target almost the

entire universe of molecules!

I hate immunosuppression!


19/30

My name is ______ and Im a B cell.

I also have very specific taste in

antigens like the T cell, in fact, I

generate antibodies when called

upon. But, I also uptake molecules

from my surroundings and present

them to T cells. When excited I turn

huge and change my name to a

plasma cell.


20/30

My name is ______ and Im a

dendritic cell. I sit literally in every area

and tissue of the body, scouting for

molecules to uptake, carry with me and

deliver them to T cells.

If I do it when my surroundings are

inflamed, the T cells will respond

aggressively. Otherwise, things look quite

differently! Ask me about Crohns

disease!


21/30

My name is ______ and Im a Lymph node.

I collect vessels from distal locations, which

contain lymphatic fluid and also dendritic cells.

Inside, I allow these to engage with T cells

and B cells.

The fluid leaves by a single duct and

eventually reaches the blood circulation.

Me? I sit behind your knee, draining your

foot to see what molecules your DCs collected.


22/30

My name is ______ and Im a protein in the Complement

system. Not cells, not tissues, were just a group of

circulating proteins that can start a cascade of cleavageevents from various triggers. Once activated, we can kill a

cell, and we can attract cells to a damaged area.


23/30

My name is ______ and Im an

Antibody. Also a protein. Im very

specific about my target, which

makes me a wonderful tool for

researchers.

The fun thing is, that my

chromosomal DNA that makes-up

my amino-acid sequence is not like

the rest of the body! Weird ha!


24/30

My name is ______ and

Im your bone marrow!


25/30

Skin? Immunology?


26/30

Who do we attack?

Infectious? Non-infectious?

Both?


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29/30

Is it a T cell disease?

Is it a B cell disease?

Is it both?

Is it neither?

Is it an inflammatory disease?

Is it viral?

Is it a toxin-related disease?


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1 introduction lesson - reading 3-15

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