1 estimation of cancer risks and benefits associated with a potential increased consumption of...
DESCRIPTION
3 Paper Accepted to Food and Chemical Toxicology Link: dx.doi.org/ /j.fctTRANSCRIPT
1
Estimation of cancer risks and benefits associated with a potential increased consumption of fruits and vegetables
Rick ReissExponentSeptember 25, 2012
2
Acknowledgments Partially funded by the Alliance for Food & Farming,
which represents farmers and farm groups
Collaborators include Dr. Carl Keen (UC Davis) and Jason Johnston, Kevin Tucker, and Dr. John DeSesso (Exponent)
3
Paper Accepted to Food and Chemical ToxicologyLink: http://www.sciencedirect.com/science/article/pii/S0278691512006394
dx.doi.org/10.1016/j.fct.2012.08.055
4
Outline of Presentation Review of consumer perception of pesticide residues Methodology of paper:
Estimation of cancer prevention benefits Estimation of cancer risk from pesticides
Results Caveats and uncertainties Conclusions
5
Introduction Most fruit and vegetables contain small levels of
pesticide residues
There is significant consumer concern about the potential effect of these residues
Any concern must be balanced by the substantial health benefits of eating fruits and vegetables
6
Several Public Campaigns Aimed at Pesticide Residues Environmental Working Group’s “Dirty Dozen”
No consideration of toxicity or risk Not transparent how the “dirty dozen” is determined
Organic Trade Association’s “Dietary Risk Index” Throws out non-detects from analysis Conflates acute and chronic consumption data
7
Residues Are Prevalent but Small – Pesticide Data Program (2008 PDP)
8
Dr. Oz: Scaring Consumers
9
Cancer Risk Perception Many consumers see pesticide residues on food as a
significant risk concern About 70% of Spanish respondents considered avoiding
pesticide-treated fruits and vegetables as a means to prevent cancer (Garcia et al., 1999)
Organic food buyers estimated the risk of mortality from consuming conventionally-grown food to be similar to a 1 pack per day smoker (Hammitt, 1990)
The Alar scare in 1988 resulted in “near hysteria” (American Dietetic Association, 2007).
10
Cancer Risk Perception Many consumers do not identify fruits and vegetables
consumption as a way to prevent cancer: About ½ of survey respondents did not identify fruit and
vegetable consumption as a protective effect against cancer
It is time to correct some of these perceptions, to the extent possible
11
Prevention of Cancer from Fruit and Vegetable Consumption Hundreds of studies have been conducted
WCRF/AICR meta-analysis of epidemiologic studies found “probable” evidence of a benefit for several cancers Case for prevention has weakened somewhat over time, but
is still strong “Probable” evidence for mouth, pharynx, larynx, esophageal,
stomach, and lung cancer (fruits and/or vegetables) Relative risks provided for these cancer types
12
Cancer Sites with Decreased Risk for F&V Consumption(“Probable”)
13
Cancer Sites with Decreased Risk for F&V Consumption(“Limited”)
14
Studies for Green-Yellow Vegetables and Stomach Cancer
15
Prevention of Cancer from Fruit and Vegetable Consumption Assumptions for estimate:
Reasonable estimates for prevented cases can be estimated from the RRs from the WCRF/AICR meta-analysis
Estimate based on half of the population with least fruit and vegetable consumption increasing consumption by 1 serving each of fruits and vegetables (80 gram/day serving)
Avoided cases based on RRs and SEER background cancer rates.
To avoid overestimates, an average of fruit and vegetable estimates were used.
RR from lung cancer case-control was dropped as an outlier
16
Estimation of Cancer Risks Steps:
1. Assemble PDP data from 2004-2008.2. Identify pesticides with cancer unit risk estimates from EPA
(21) (OPP and IRIS estimates)3. Used consumption data from the CSFII (94-96, 98). Use
surrogates to account for all food items. Estimate average exposure (assume as lifetime exposure).
4. Apply standard cancer risk assessment methods to estimate total cancer risk for pesticides in the diet (i.e., Risk = Exposure X Q1*)
5. Adjust to 80 gram serving each of fruits and vegetables.6. Current U.S. population assumed as 310 million
17
Cancer Risk Benefit Analysis for Fruit and Vegetable Consumption (Annualized)
18
Summary of Avoided Cases (Annualized)
Cancer Site Avoided Cases
Pharynx 5839Larynx 1946
Esophagus 3431Stomach 4191
Lung 6112
19
Chemicals Contributing to Cancer Cases for Vegetable Consumption
20
Uncertainties – Cancer Benefit Estimates Strengths of epidemiologic data:
Based on humans! Lots of different studies Central estimates of risk Includes pesticide risk (essentially a net benefit)
Weaknesses of epidemiologic data: Confounding is always a concern Consumption estimates are uncertain Some researchers think the cumulative evidence is weaker
than “probable” (Key, 2011)
21
Uncertainties – Cancer Benefit Estimates Confirming evidence
Mechanistic evidence for components of F&V including carotenoids, lycopene, folic acid, and Vitamin C (tumor initiation and progression).
Boffetta et al. (2010) study of European population found similar estimates
22
Uncertainties – Cancer Risk Estimates Risk based on EPA cancer unit risk factors:
Based on high dose rodent bioassays. Use an extrapolation method to estimate risk at lower,
untested doses. For example, lowest dose in permethrin study was 3
mg/kg/day, whereas average exposure was 1.3x10-4 mg/kg/day (20,000-fold difference)
EPA on its cancer risk estimates: “while uncertain, are more likely to overstate than understate hazard and/or risk.”
23
Uncertainties – Cancer Risk Estimates Criticisms of rodent bioassays (Ames and colleagues):
High doses lead to chronic wounding of tissues, cell death, and chronic cell division of neighboring cells to replace damaged tissue. Causes cancer at high doses that would not occur at lower
doses. 99.9% of pesticides in the diet are from natural sources
Of the small number of natural plant pesticides that have been tested with rodents, half are positive.
24
Diuron Cancer Bioassay vs. Exposure
Group (mg/kg/day) Tumor Incidence
0 1/49
3.75 0/50
37.5 1/49
375 35/48
Average exposure ~ 2x10-9 mg/kg/day
25
Uncertainties – Cancer Risk Estimates Evidence contrary to carcinogen classification for
dieldrin: Study of 570 workers at a production plant from 1954-1970
(Van Amelsvoort et al., 2009). No elevation of cancer incidence. Results not consistent with Q1* (Sielken et al., 1999)
No association with cancer and organochlorine exposure in the Agricultural Health Study (Purdue et al., 2007).
26
Uncertainties – Cancer Risk Estimates Potential sources of underestimation:
Non-detect residues were counted as zero No practical way to do otherwise
Some pesticides are considered “possible” carcinogens and do not have Q1* values – these were not included Counterbalanced by not including F&V-cancer associations
with “limited” evidence.
27
Reliability of Data Sources
Factor Cancer Benefit Estimate
Cancer Risk Estimate
Extrapolation from animals to humans
Not necessary Necessary
Extrapolation from high dose to low dose
Not necessary Necessary
Central estimate or upper-bound
Central estimate Upper-bound
Potential confounding Yes No
28
Conclusions Benefits of eating fruits and vegetable far outweighs
any potential risks from pesticide residues For cancer residue effects are 1/2000th, at most, for
prevention benefits Risk estimates for residues are likely overestimated
Estimates are strongest on a comparative basis.
Substantially more attention is given to the pesticide residue effects than on the benefits Public health would be served by this perception changing.