1 epidemiology in groningen what is epidemiology our department projects in our department special...
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Epidemiology in Groningen
• What is epidemiology
• Our department
• Projects in our department
• Special Oncology
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Definition of epidemiology
• “The study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to control of health problems”
• The study of the occurrence of a disease in a population, in relation to its determinants.
http://bmj.bmjjournals.com/collections/epidem
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Epidemiology is occurrence research
• Object of research: occurrence relation
Outcome = ƒ(determinants)
– Determinants are all factors that influence the frequency of a disease (causal or not-causal)
– Outcome may include (other) risk factors, disorders, disease progression/cure, burden of disease, costs
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Department of Epidemiology at UMCGFacts• Established February 2005
• Union of epidemiology, data management and MTA groups from Medical School and Academic Hospital
• Focus on own research in collaboration with strong clinical research groups
• Clinical Research desk (CRD) for consultancy
• Teaching in several Bachelors and Master programs, including new MSc Epidemiology program
• About 65 people– 8 associate/full professors– ~25 scientific staff
www.EpidemiologyGroningen.nl
www.EpidemiologyGroningen.nl
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Scientific output 2005
• 81 PubMed publications
– 27 first, second, last author
• 2 PhD-theses completed (co-promotor)
• 24 grant applications
– ≥ 5 granted
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Organization
• Two sections
– Research & Education R&E (O&O)• Diabetes/obesity• Cardio-renal disorders• Lung diseases• Oncology• Psychiatry• Medical statistics• Genetic epidemiology• MTA
– Research support (RCC)
• Management team
– Secretary, supporting staff
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Department of Epidemiology
Ongoing projects offering excellent
research opportunities
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Chronic diseases are the greatest threat to quality of life and have one thing in common: ageing is the number 1 risk factor
75%
100%
125%
150%
175%
200%
225%
2005 2015 2030
Source: WHO, Global Burden of Disease Estimates
1) Disability Adjusted Life Year
• Diabetes
• Alzheimer’s
• Cancer
• Parkinson’s
• All diseases combined
• Communicable, hereditary and nutrition related diseases
Age-related (chronic) diseases
Burden through age-related diseases [worldwide loss in DALY’s1), 2005 =100%]
Index 2005
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LIFELINES
• Focus on modification of universal risk factors for
multifactorial diseases
Population-based study
165.000 participants from the northern provinces of the
Netherlands
Three-generation study design
Multiple UMCG departments involved
www.lifelines.nl
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Purpose of LifeLines
Central question
• Why do some people get old in a healthy manner, and why
have others already severe impairments or diseases early
in their life?
Focus on
• Multifactorial diseases (gene + environment)
• Factors which cause more than one disease
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Main focus of LifeLinesFrequently occuring diseases with high impact
Cardio-renal disease
Ag
ein
g
Lung disease
Metabolic disease
Psychiatric disease
Note: many diseases are defined by an arbitrary cut-off in a continuous disease marker or endophenotype.
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LifeLines cohort dimensionsThe study will cover 30,000 index persons (probands or propositi) with an age between 25 and 50 years in
a defined geographical area, and subsequently assess and follow their family members
propositus
partner
father
mother
partner’sfather
partner’smother
child 1
child 2
Aselect:30.000
Partner assumption:20.000
Family assumption:2 children
Children involved assumption:40.000
Parents alive assumption:75.000
Total number ofparticipants:
165.000
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Mental disease- TRAILS
• Aims at understanding the origins of mental disease
• Provides a multitude of repeatedly measured psychosocial
and biological data
• Included a cohort of more than 2000 adolescents from the
general population
• Principally carried out by the department of Psychiatry
• www.trails.nl
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Cardiovascular disease - PREVEND
• Directed at the assessment of the impact of
microalbuminuria
• Focus is on renal and cardiovascular disease
• Cohort study with 8592 persons from the general
population
• Carried out in close collaboration with the department of
Internal Medicine
• www.prevend.org
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Adiposity - GECKO
• Focus on development of body weight during the first year of life
• Measures of metabolism, genetics, parental life style
• Includes a cohort of all children born in Drenthe during one year
(N=5500)
• Carried out in close collaboration with the department of
Pediatrics
• www.rug.nl/umcg/faculteit/disciplinegroepen/kindergeneeskunde/
gecko
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COPD - VLAGTWEDDE/VLAARDINGEN
• Sample of the general population of the Netherlands
followed up for 25 years
• Measurements of FEV1, single nucleotide polymorphisms,
life style factors (smoking)
• In collaboration with the department of Pulmonary Diseases
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Oncology – CANCER REGISTRY
• Early detection of breast and ovarian cancer in families with
BRCA mutations
• Follow-up after breast cancer
• Incidence and determinants of irradical tumor resection