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E-Seminar Protocols
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One-Minute NMR2006 demo tour
• Chicago Area NMR Group: Madison, WI; Nov.11• KSU Functional Genomics Meeting: Manhattan, KS; Oct. 23-24• SMASH: Burlington, VT; Sept. 10 - 13• Am. Soc. of Pharmacognosy: Arlington, VA; Aug. 6 – 9• ENC: Monterey, CA; April 24 – 28
13 December 2006
Presented by Tim Peck &
Dean Olson
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One-Minute NMR2006 demo tour
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New Tools: New Scientific Advances
Chemical AssignmentRapid Dereplication via HPLC
Gronquist, Meinwald, Eisner, F. C. Schroeder, JACS 2005, 127, pp. 10810-10811
dqf-COSY spectrum 8 scans 512 complex incrementstotal time 3 h 45 min
coupled non-gradient HMQC spectrum 16 scans, 512 complex incrementstotal time 7 h
non-gradient HMBC spectrum baseline-subtracted in F164 scans, 460 complex incrementstotal time 21 h 45 min
NOESY spectrum 16 scans, 256 complex incrementstotal time 4 h 18 min
dqf-COSY
HMQC
HMBC
NOESY
S. Van der Sar, J. Blunt, and M. Munro, Org. Let. 2006, 8(10), pp. 2059-2061
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One-Minute NMR:Integrated System Approach
6- or 12-TrayCapacityfor Vialsor Trays
Multi-SolventWash Station
SampleReturn
Accident-FreeSyringeand Needle
Web-basedSoftware
Well Plate or VialSample Format
CapNMR Probe5- or 10-µL
DiscoveryTower
On-BoardInstrument
Server
• Microliter precision• 0.1 mm xyz positioning
Well Plate orVial Tray
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Automation: Accident-Free Syringe and Needle
Carriage comes to restbefore needle is lowered
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Automation: Solvent Conditioner
Solvent BottlesUnder Positive Pressure
Solvent ConditionerVacuum Pump
Result: Dry, Degassed, ProtectedDeuterated Solvent
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IntegratedApproach
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MicroFlow NMR Literaturewww.microNMR.com
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Your MicroFlow NMR Product Sourcewww.protasis.com
Technical Support:www.microNMR.com