1) D E V E L O P M E N T O F G R E E N C H E M I S T RY L A B S

2) D E V E L O P M E N T O F N E W O R G A N I C C H E M I S T RY H Y D R O G E N AT I O N L A B S

3) D E V E L O P M E N T O F O R G A N I C C H E M I S T RY L A B S U S I N G T E C H N O L O G Y T O M O N I T O R T H E R E A C T I O N

Focus of Dr. O’Connor’s Research

Hydrogenation of Methyl Trans-Cinnamate

Good reaction conditions Less than 1 hour reaction time. 1.0 atm.

Ph

CO2CH3 H25% Pd/C

RT, EtOH 1.0 atm

Ph

CO2CH3

Methyl Trans-Cinnamate Methyl-3-phenylpropionate

oCHOOSE TO USE ENVIRONMENTALLY FRIENDLY CHEMICALS.oUSE CATALYSTS WHEN POSSIBLE.oPREVENT WASTE BY USING A SOLVENTLESS PROCESS.oMINIMIZE AMOUNTS OF SOLVENTS AND REAGENTS USED.

Some Principles of Green Chemistry

General Reaction for the THP Protection of Alcohols.

O

+ ROH

O OR

Catalyst

This can be done with and without solvent. The goal is to run the reaction solventless.THP is a protecting group in organic chemistry.

O

+ PhCH2OH

O O

AlCl3 6H2O

Ph35o C, 45 Min

Avg Yield = 80%

These are Examples of Solventless

Tetrahydropyranylation Reactions

O

+ PhCH2OH

O O

Sulfamic Acid

Ph

90 Min

Avg Yield = 88%

(H2NSO3H)

The identification of other solventless reactions is presently under investigation.

TetrahydropyranBenzyl alcohol