1 data mining: investigating ivf models. 2 l 9% of married couples in the us are medically infertile...
TRANSCRIPT
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DATA MINING:
INVESTIGATING IVF MODELS
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9% of married couples in the US are medically infertile (age 15-44) = 2.3 million couples.
An additional 19% of couples have impaired ability to have children.
Total = ~7.2 million couples
From 1998 National report from Center for Disease Control
Why IVF?
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IVF Procedure:
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Many diagnoses:
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Concerns:• Less than 1/3 of IVF cycles are successful.
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Concerns:• Less than 20% of cycles result in single pregnancy.
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Concerns:• Usually many embryos are transferred.
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Concerns:• Some result in multiple births.
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Concerns:• How to predict individual patient results.
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The Data:• 12 months of statistics from 678 cycles.• Over 100 attributes for each record.
Procedural
PatientTechnology
Patient Procedural Technology
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The Data:• Procedural includes info on drug protocols, #oocytes, #blasts, embryo transfer, trauma and other cycle specific data.
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The Data:• Patient info includes patient specific data such as diagnosis, BMI, and age.
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The Data:• Technology information includes incubators, doctors, ICSItech, and catheter type among others.
ICSI (intracytoplasmic sperm injection)
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Data Mining:• A cyclical procedure.
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Data Understanding & Cleaning:• # > or = 6 Cell• Diagnoses• Day of Embryo Transfer
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Sensitivity analysis using entropy reduction:
2log ( )ik ikk
p p Entropy formula:
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Model Assessment:
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DATA MINING:
INVESTIGATING IVF MODELS