1 chapter 8: environmental health and toxicology hong kong residents concerned about sars copyright...
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Chapter 8: Environmental Health and Toxicology
Hong Kong residents concerned about SARSCopyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
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Chapter Eight Topics
• Environmental Health• Toxicology• Movement, Distribution, and Fate of Toxins• Mechanisms for Minimizing Toxic Effects• Measuring Toxicity• Risk Assessment and Acceptance• Establishing Public Policy
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Part 1: Environmental Health
In some parts of Eastern Europe and the former USSR, upto 90 % of all children suffer from environmentally linked diseases.
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At any given time, about 2 billion people suffer fromworms, protozoans, and other internal parasites.
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What is Health?• The World Health Organization
(WHO) defines health as a state of complete physical, mental, and social well-being.
• Disease - a deleterious change in the body's condition in response to an environmental factor
• Morbidity - illness• Mortality - death
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Factors Contributing to the Spread of Contagious Diseases
• High population densities• Settlers pushing into remote areas• Human-caused environmental change (change of
habitat for organisms)• Speed and frequency of modern travel• Contact with water or food contaminated with
human waste• Climate change• Increased consumption of wild species
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Part 2: Toxicology
Toxicology: The study of toxins (poisons) and their effects on living systems.
What does toxic mean?
Environmental Wisdom…visit
http://www.dhmo.org
What does Toxic mean
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Antibiotic and Pesticide Resistance• Indiscriminate use of antibiotics and
pesticides - perfect recipe for natural selection
• Protozoan that causes malaria now resistant to most antibiotics, and mosquitoes have developed resistance to many insecticides
• Drug resistance: TB, Staph A, flesh-eating bacteria
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Hazardous and Toxic Chemicals• Allergens -
formaldehyde
• Immune system depressants
• Neurotoxins - lead, DDT
• Mutagens
• Teratogens - alcohol
• Carcinogens
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Clorox
• Kills Flu Virus• Vapors may irritate, harmful if swallowed, do not get in the eye or
clothes, avoid prolonged breathing of vapors, use in highly ventilated areas, not recommended for use by people that have heart problems, or breathing problems.
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Factors to consider
• Solubility and mobility (organic Vs inorganic)
• Exposure and susceptibility
• Bioaccumulation and biomagnification
• Persistence
• Chemical interactions (antagonistic Vs synergistic)
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Bioaccumulation and Biomagnification
• Bioaccumulation - dilute toxins in the environment can reach dangerous levels inside cells and tissue
• Biomagnification - the effects of toxins are magnified through food webs
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Part 4: Minimizing Toxic Effects
• Every material can be poisonous under some conditions.
• Taken in small doses, most toxins can be broken down or excreted before they do much harm.
• Liver - primary site of detoxification
• Tissues and organs - high cellular reproduction rates replace injured cells - down side: tumors, cancers possible
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Part 5: Measuring Toxicity
• Most commonly used and widely accepted• Expensive - hundreds of thousands of dollars to
test one toxin at low doses• Time consuming• Often very inhumane• Difficult to compare toxicity of unlike chemicals
or different species of organisms
Animal Testing
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Acute Versus Chronic Doses and Effects
• Acute effect - immediate health effect caused by a single exposure to a toxin (can be reversible)
• Chronic effect - long lasting or permanent health effect caused by (1) a single exposure to a very toxic substance or (2) continuous or repeated sub lethal exposure to a toxin
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Part 6: Risk Assessment and Acceptance
• Risk - the probability of harm times the probability of exposure
• A number of factors influence how we perceive relative risks associated with different situations.
• Accepting risks - we go to great lengths to avoid some dangers, while gladly accepting others
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Part 7: Establishing Public Policy
• Combined effects of exposure to many different sources of damage
• Different sensitivities of members of the population
• Effects of chronic as well as acute exposures
In setting standards for environmental toxins, we need to consider: