1. central dogma dna rna protein dna is made of nucleotides of deoxyribose (sugar) po 4...
TRANSCRIPT
BUILDING BLOCK/MONOMER DNA is made of nucleotides of
Deoxyribose (sugar) PO4 (phosphate group) Nitrogen bases
1. adenine—A 2. guanine—G 3. thymine—T 4. cytosine—C
phosphate group
deoxyribose (sugar)
nitrogen-containingbase
NITROGENOUS BASES
Double ring PURINESAdenine (A)Guanine (G)
Single ring PYRIMIDINESThymine (T)Cytosine (C) T or C
A or G
hydrogen bond
covalent bond
BASE PAIRING RULES A bonds to T with 2 hydrogen bonds
G bonds to C with 3 hydrogen bonds
Double helix
REPLICATION DNA makes a copy of DNA Where? In the nucleus DNA makes DNA
CGATATATTCCCGAG
ATTCAGTTCAGACCC
ACGTTATACGCTAAC
RNA DIFFERS FROM DNA1. RNA has a sugar ribose
DNA has a sugar deoxyribose2. RNA contains the base uracil (U)
DNA has thymine (T)3. RNA molecule is single-stranded
DNA is double-stranded
7
THREE TYPES OF RNA Messenger RNA (mRNA) -
carries genetic information to the ribosome
Ribosomal RNA (rRNA) - makes the ribosomes
Transfer RNA (tRNA) - transfers amino acids to the ribosomes where proteins are made
10
.
MESSENGER RNA (MRNA)
11
A U G G G C U C C A U C G G C G C A U A AmRNA
startcodon
codon 2 codon 3 codon 4 codon 5 codon 6 codon 7codon 1
mRNA has a code (codon) for tRNA
TRANSLATION RNA protein Where? In cytoplasm. The chain of amino acids linked
together is a specific protein.
animation
FOR YOU TO TRY… TRANSLATIONMAKE AMINO ACIDS FROM MRNA
GCUAUAUAAGGGCUC
UAAGUCAAGUCUGGG
UGCAAUAUGCGAUUG
PUT IT ALL TOGETHER Given the following DNA sequence
CGATATATTCCCGAG 1. What is the complimentary DNA?
2. What is the mRNA strand (codon)?
3. What is the tRNA (anticodon)?
4. What amino acids are created?
WHAT IF THERE IS A MISTAKE? MUTATION-error
Substitutions Insertions Deletions Frameshift Translocation Inversion
Not all are harmful
FRAMESHIFT MUTATIONS HAPPEN BECAUSE OF INSERTIONS OR DELETIONS
Original: The fat cat ate the wee rat.
Frame Shift (“a” added): The fat caa tet hew eer at.