1-antihyperlipidemics
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PEÑAMANTE, Fides Grace C. PH-INFO4A – Pharmacy Antilipidemics
Generic Name: ATORVASTATIN
Structure:
IUPAC Name: 7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoateTrade Names Manufacturer Price
Avamax Therapharma10mg x 100's – ₱2,625.00 – 26.25/tab20mg x 100's – ₱3,090.00 – 30.90/tab40mg x 100's – ₱3,745.00 – 37.45/tab
Bestatin XL Lab/Ambica 10mg x 50's – ₱550.00 – 11.00/tab
Itorvaz Bell-Kenz Pharma40mg x 30's – ₱690.00 – 23.00/tab 80mg x 30's – ₱720.00 – 24.00/tab
Lipitor Pfizer10mg x 100's – ₱3,272.75 – 32.72/tab 40mg x 100's – ₱4,797.50 – 47.97/tab20mg x 100's – ₱3,717.35 – 37.17/tab 80mg x 100's – ₱4,809.85 – 48.09/tab
Xentor Xeno10mg x 30's – ₱632.50 – 21.00/tab 40mg x 30's – ₱977.00 – 32.57/tab20mg x 30's – ₱810.00 – 27.00/tab 80mg x 30's – ₱977.35 – 32.58/tab
Dosage Forms and Strength: Tablets 10mg FC tab, 20mg FC tab, 40mg FC tab, 80mg FC tab
Clinical Indications:
As an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels and to increase HDL-C in patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Types IIa and IIb);
As an adjunct to diet for the treatment of patients with elevated serum TG levels (Fredrickson Type IV); For the treatment of patients with primary dysbetalipoproteinemia (Fredrickson Type III) who do not respond adequately to
diet; To reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering
treatments (e.g., LDL apheresis) or if such treatments are unavailable; As an adjunct to diet to reduce total-C, LDL-C, and apo B levels in boys and postmenarchal girls, 10 to 17 years of age, with
heterozygous familial hypercholesterolemia Reduction of risks of myocardial infarction, stroke, revascularization procedures and angina
Pregnancy Category: Category X: Because of the potential for adverse reactions in nursing infants, women taking this drug should not breastfeed; contraindicated in nursing mothers.
VILLACRUZES, Christian Ray C. PH-INFO4A – Pharmacy Antilipidemics
Generic Name: FENOFIBRATE
Structure:
IUPAC Name: 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid, 1-methylethyl ester
Trade Names Manufacturer Price
Fenoflex LR Imperial 160mg cap x 30’s – ₱1030.49 – 34.35/tab
Fibrafen Patriot 200mg cap x 30’s – ₱1588.40 – 53.00/tab
Lipanthyl Abbott67mg cap x 60’s – ₱1432.37 – 23.87/tab160mg tab x 30’s – ₱1880.21 – 62.67/tab145mg tab x 30’s – ₱1238.43 – 41.28/tab
Lipway Cathay Drug 250mg cap x 30’s – ₱1041.60 – 34.72/tab
Lofibra OEP Phils 200mg cap x 50’s – ₱1090.00 – 21.80/tab
Dosage Forms and Strength:
Capsules 67mg, 160mg, 200mg, 250mg
Tablets 145mg, 160mg
Clinical Indications:
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Treatment of types IIa, IIb, III, IV & V hyperlipoproteinemias. Treatment of mixed hypercholesterolemia, hypertriglyceridemia, correction of low HDL in adults & treatment of dyslipidemia
associated w/ metabolic syndrome & diabetes when the response to diet & lifestyle modification is inadequate. Treatment of secondary hyperlipoproteinemias.
Pregnancy Category:Category C: Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
SALADAR, Lance Alistaire K. PH-INFO4A – Pharmacy Antilipidemics
Generic Name: GEMFIBROZIL
Structure:
IUPAC Name: 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acidTrade Names Manufacturer Price
Lipigem Littman 300mg cap x 100’s – ₱1100.00 – 11.00/tabLipizile Integrated Pharma 300mg cap x 100’s – ₱1035.00 – 10.35/tab
Lopid Pfizer
300mg cap x 100’s – ₱5666.85 – 56.67/tab600mg cap x 60’s – ₱5647.19 – 941.20/tab900mg tab x 50’s – ₱5356.43 – 107.13/tab
900mg tab x 100’s – ₱10712.85 – 107.13/tab
Reducel GXI300mg cap x 100’s – ₱1131.00 – 11.31/tab600mg tab x 100’s – ₱1737.00 – 17.37/tab
Gempar (India) Cadila Pharmaceuticals Ltd. 300mg cap x 10’s – 73.20/tab
Dosage Forms and Strength:
Capsules 300mg, 600mgTablets 600mg, 900mg
Clinical Indications:
Treatment of hyperlipidemia Long-term treatment & prophylaxis of patients w/ CHD & Myocardial Infarction Reduces risk of CHD & Myocardial Infarction Primary prevention of ischemic heart disease Treatment of Mixed dyslipidemia: Fredrickson types IIA, IIB, III, IV, V. Treatment of hyperlipidemia associated w/ diabetes, xanthomata associated w/ hyperlipidemia, hypertriglyceridemia.
Pregnancy Category:Category C: Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
MAGBOO, Mark Scyld PH-INFO4A – Pharmacy Antilipidemics
Generic Name: ROSUVASTATIN
Structure:
IUPAC Name: (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acidTrade Names Manufacturer Price
Crestor Astra Zeneca
5mg tab x 30’s – ₱796.00/blister10mg tab x 30’s – ₱1730.00/blister20mg tab x 30’s – ₱2105.00/blister40mg tab x 30’s – ₱2741.00/blister
Lipicheck OEP Phils10mg tab x 30’s – ₱567.60 – 18.92/tab20mg tab x 30’s – ₱851.35 – 28.38/tab
Roswin LR Imperial10mg tab x 30’s – ₱900.00 – 30.00/tab
20mg tab x 30’s – ₱1050.00 – 35.00/tab
Rustor InnoGen Pharmaceuticals10mg tab x 30’s – ₱792.00 – 26.40/tab
20mg tab x 30’s – ₱1200.00 – 40.00/tab
Rovista Getz Pharma5mg tab x 10’s – ₱120.00 – 12.00/tab
10mg tab x 10’s – ₱250.00 – 25.00/tab20mg tab x 10’s – ₱290.00 – 29.00/tab
Dosage Forms and Strength: Tablets 5mg, 10mg, 20mg, 40mg
Clinical Indications: Reduction of LDL-cholesterol, apolipoprotein B & triglycerides & to increase HDL-cholesterol in the management of
hyperlipidemias including primary hypercholesterolemia (type IIa), mixed dyslipidemia (type IIb), hypertriglyceridemia (type IV). Also used in patients w/ homozygous familial hypercholesterolemia.
Pregnancy Category:Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
VASQUEZ, Julia Francheska L. PH-INFO4A – Pharmacy Antilipidemics
Generic Name: SIMVASTATIN
Structure:
IUPAC Name: (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
Trade Names Manufacturer Price
Afordel Merck20 mg tab x 150's – ₱2328.78 – 15.52/tab40 mg tab x 150's – ₱3094.70 – 20.63/tab
40 mg tab x 30's – ₱618.94 – 20.63/tab
Cardiosim Cathay YSS 20 mg tab x 30's – ₱436.80 – 14.56/tab40 mg tab x 30's – ₱546.00 – 18.20/tab
Cholestad Littman 20 mg tab x 100's – ₱2200.00 – 22.00/tab40 mg tab x 100's – ₱3400.00 – 34.00/tab
Vidastat Therapharma 10 mg tab x 30's – ₱827.50 – 27.58/tab 40 mg tab x 30's – ₱1151.80 – 38.39/tab20 mg tab x 100's – ₱3082.28 – 30.82/tab 80 mg tab x 30's – ₱1151.80 – 38.39/tab
Zimcor Sydenham 40 mg tab x 30's – ₱585.00 – 19.50/tab80 mg tab x 30's – ₱1080.00 – 36.00/tab
Dosage Forms and Strength: Tablets 10mg, 20mg, 40mg, 80mg
Clinical Indications:
Treatment of hyperlipidemia; adjunct to therapy in patients w/ homozygous familial hypercholesterolemia; prophylaxis in hypercholesterolemic patients w/ ischemic heart disease. Treatment of types IIa, IIb, III, IV & V hyperlipoproteinemias.
Adjunct to diet for treatment of hypercholesterolemia. High-risk CHD w/ or w/o hypercholesterolemia eg diabetes, history of stroke or other cerebrovascular disease, peripheral vessel disease or w/ existing CHD to reduce the risk of CV death major CV events eg stroke & angina pectoris.
Used to reduce LDL-cholesterol, apolipoprotein B & triglycerides.
Pregnancy Category:Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.