1 3 i - usda-aphis...certificate number: 43-r-0005 customer number: 1487 form approved om0 no....

See attached form for additional information.

- nls rep^ is required by law (7 USC 2143). Failure to repm according to the regulations can :esult in an o'der to cease and desst and to be subject to penalties as provided for in Section 21:

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

1. CERTIFICATE NUMBER: 43-R-0005

CUSTOMER NUMBER: 1487

FORM APPROVED OM0 NO. 05754036

Mallinckrodt Inc 2703 Wagner Place P 0 Box 5840 Maryland Heights, MO 63043

ling. or experimentation. or held for these purposes. Attach additional sheets if necessary ) 1

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT )

Telephone: (314) -654-2000

1. REPORTlNG FACILITY ( List all tocations where animals were housed or used in actual research, test -. - -

FACILITY LOCATIONS ( S~tes ) - See Atached Lstmg

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY f Attach additional sheets if necessarv or use APHIS Form 7023A ! I A. I B. Number of animal

/ beingbred, I conditioned, or

Animals Covered held for use in By The Animal i teaching. testing,

Welare Regulations experiments,

Number of 1 0. animats upon . which teaching. research. experiments, or tests were conducted

I

involving no pain, I

distress, or use a pain-relicwing drugs. i

Number of animals upon which experiments. teaching, research. surgery. or tests were conducted invotving accompanying pain or distress to the animals an for which appropriate anesthetic, analgesic, or tranquilizing drugs were used.

-

E. Number of animals upon which teaching, experiments. research, surgery or tesn were conducted involving accompanying pain or distress to the animals and for wt the use of appropriate anesthetic, analgesic, or tranquiliz drugs would have adversely affected the procedures, res or interpretation of the teaching. research. experiments, surgery, or tests. ( An explanation of the procedures producing pan or distre!$s in these animals and me mast

i such d ~ g s were not used must be aftached to this repM

!

TOTAL NUMBER OF ANIMALS

( COLUMNS C + D + E )

: research. or ' surgery but not yf : used for such

Purposes-

...... .-

4. Dogs ..... .

5. Cats .-- - --

6. Guinea Pigs

" ' - 3 ...... - - " 1

7. Hamsters - I .-. -2 - .- . - -. . 8. Rabbits 1

1 _^ .... 9. Nonhuman Primates I "I 10. Sheep

1 1. Pigs .. -- ..... I- . - 12. Other Farm Animals

---I--- ..............

13. Other Animals

............. - . *- - . .-- - -- I-. ,. i I

........ -- I - . . . . ! 1-

1) Professionally acceptable standards governing the care, treatment, and use of animals, induding appropriate use of anestefic, analgesic, and tranquilizing drugs, priw to, during. and following actual rese. teaching. testing, surgery, or experimentation were followed by this research facility.

2) Each prinapal investigator has considered ahernativas to painful procedures.

3) This facility IS adhering to the standards and regulations under the Act, and it has r ~ u i r e d that exceptions to the standards and regulations be specified and explained by the principal investigator and apf Institutional Animal Care and Use Committee (IACUC). A summay of all such exceptions is attached to this annwt report In addition to identifying the IACUGapproved excepbons. this summary in tmef explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has apprqmate authority to ensure the provisim of adequate veterinary care and to oversee the adequacy of m e r aspects of animal care and use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL cial )

1

NAL OFFICIAL i Type orPnnl)

DATE SIGNED

ANNUAL REPORT OF RESEAESH FAClLlTY ( TYPE Of? PRiNT )

This report is required by law (7 USC 2143). Failure to report according to the regulations can See attached form for

result in an order to cease and desist and to be subject to penalties as prowded for in Section 21f additional information.

I Nestle Purina Petcare Company 101 Science St Gray Summit, MO 63039

UNITED STATES DEPARTMENT OF AGRICULTURE ANlMAi AND PLSNT HEALTH INSPECTION SERVICE

I Telephone: (636) -451 -2223

L. REPORTING FAClLlM ( List all locations where ani.r.als were housed or use? ;-. aciua! research, testing, or experimentation, or held for these purposes. Attach additional sheets C necessery ) C

1. CERTIFICATE NUMBER: 43-R-OOQI


"I- ZII ITY LOCATIONS ( Sites ! - See Atached Listing

J

FORM APPROVED OM0 NO. 0579-0036

REPORT OF ANIMALS USED BY OR UNDER CONTROL 0' RESEPifZH FACILITY I Attach additional sh -- e.- --

A. Number of animal .) C . Numbtzr of D. N~mber of animals upon E. Number of animals upon m i c h teaching. experiments. F. , being Srcd, :..%mals up-fi which experiments. research, surgery or tests were crmducted involving

conditioned, or which teaohing. teaching, research. i accompanying pain or distress to the snimals and for ~ . ( r :

.b.nimal= Covered !?e!d !or use ir! researc?. surgery, or tests w e e the use of appropriate anesthetic, analgesic, or tranquiliz / By The Animal teaching, testing, e~periments, or Q-onducted involving drugs would have adversely affected the p:ocedures, res '3F "'N!rA4LS

Welfare Regulaticns erperimen:~. tests we,':: accompanying pain or a or interpretation of the teaching, research, experiments. research. zr c. ld.xted 1 i k t ; ~ ts the animals an surgery, or tests. ( An explanation of the procedurc~i ( CC-UMNS surc$ry but n 9 !r invc'4n2 no 7 in. ' fnr u!hich appropriate producing pain or distress in these snimals and the reas ~r -I- [ I + / j used for such di=tr%-. or us: m ' anesthetic, analgesic, or such drugs were not used must be attached to this repor! purposes. pain-rei~lving 1 tranquiiizing drugs were

used. I i -t------- -

-- - -- - 4. Dogs

-

6. G~l~*.sa Fl:s I

- - - - - - - - - - - - . - - - - "1'. Sheep - --- -- - - - - ' 1. Pigs -- - -- -- j - - - - - . . - -

1 i

-+- -- 12. Other r a m Aniwsls - - -. -- -- - I

-I- - t --- ----- -- a-

I

. m i - - - - ~~Z~ZLTKZ~A . -- ---a - - -a-a .--:

1 ---A

1 : Prof~ssionally acce:,:able standards govemiz~ the care. *reatme'., e d : sz c; ar.;,r:ls. ~ l , x d i n g ap,xopriau: dse of anestetic. anqesic. and t ran~~~ i l i z i r~g cirugs, prior to, during, and fol!owing actual ,.?%. ieachirq testizg, surgery, ?r expcrimentation were fc!lowed by tnls re:.: arch faciiity.

2) Each principai investigator has cmsidcred a~krnatives to , t i iAzful pcedures.

3; 73:s faJ:ity :: adhc- i g to tt,: s ta~ la rds and regilatioris under the sct, ana 11 has r q t . .. ad ~h,,' a~ztr.lior,s i~ the s:~ndards and rocplations be s!. xifieo ,nd explained i'y :he principal invesr: xstor an< bpt Instit~tiom; Animal Gale and \Ise ~ 'omm ::ee (IACUC). sLPmmary of all such dccep!ionJ ib ~ttac,-ed to tni- anr,& report. !n addition to identifyin!: the IACW-approved t.~rep!;ons, th: ,sum mo... in1 brief 3xlr.nlans:ion o i :,~e eYr:$ic:t1s, as well a: tke species and nur~toer of animals dfzr-..;.

4) T k att-.ldi:,~ vc?arinarian for this rcsearrh facility h:l; arrompriaie authorit)#:,: ensure line prr,./isioq d ::doqbate veiera81a::; care and to cversae P-2 atiequacy of other aspects of animal Lzre zne use. -w a IP I-- - -- m

CEUTIF:CAT13N BY HEADZ;'ARi<SS PESFARC+I FACILX'Y 3FFICi4i ( Chief E..=cutive Officer or .ey-:iy Gsspon,=tble lnsiitutional Official ) I

- \ j, \,# .,

4 ' 4 R*on tonlml No.: This repofi it required by kw (7 USC 2143). Falun to repod u u m h g to the regulstionr a n rcrull in m order to cease and desist md to be subicd to uenaltles as wovided for in Ssction 21:

UNITED STATES DEPARTMENT OF AGRlCULTURE ANIMAL AND PUNT HEALTH INSPECTION SERVlCE

1. CERTIFlCAlE NUMBER: 43-R-0008 I FORM APPROVE0 OMB NO. 0579-0036

CUSTOMER WMBER: 1444

Washington University Lindell8 Skinker Blvds St Louis, MO 63130

ANNUAL REPORT OF RESEARCH FACILITY ( W E OR PRINT )

Telephone: (314) -362-3229

I. REPORTING FAClUTY ( Ust a1 locahans w h a ~ animals warm housed or used in rehral ~ r d r , tcsl

FACILITY LOCATIONS ( Sites ) - S.e h c b d tism

I REPORT OF ANIMALS USED BY OR UNDER H FAClLrrY f Attach I d d i shWs If rrcrcecurv or use APHIS Form 7423A 1 1

TOTAL NUMBER OF AUUULS


4. Dogs

6. Guinea Pigs I 86

12. ahar Farm Animals

13. O b f Aniik

Gerbils Chinchillas

{ AUG Dl )

2. Location(s) of Business, Exhibition Site(s) or Research Facilities

Customer ID - 1444

Washington University School of Medicine 660 S Euclid Ave St. Louis, MO 631 10

Washington University Hilltop Campus Lindell & Skinker BIvds St. Louis, MO 631 30

This repar: is required by a w (7 USC 21231. Failure io report accoraing :o :he requletions can result in an order LO cease and deslst an3 tc be subiect ;o oena:ties as ~mvidec tor ic Saction 21t

See rttacned form for addainal information.

UNITED STATES DEPARTMENT OF AGRlCtlLTURE ANIMAL AND PLANT HEALTH 1NSPECTION SEWICE

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PAINT )



Midwest Research lnst 425 Volker Blvd Kansas City, MO 641 70

t FORM APPROVED OM8 NO. 05794036

. REPORTING FACILITY ( Lisl all locations where animals were h w ~ s e c or usea in actrral research. testing, or exuerimentation. or heio for these pumses. Attach additional sheets if necessary ) 1 FACILITY LOCATIONS ( Sites ) - See Atached Listing 425 Volker Boulevard

Kansas City, MO 64110 - . REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets ff necessarv or use APHIS Form 7023A 1 1

A. I 8. Number of animal being bred. conditioned, or

Animals Covered 1 he16 for use In By The Animal teaching. testing,

Wetf'an Regulations ' experiments. research, or surgery but not yr used for such purposes.

..-.

4. Dogs I 5. Cats 27 6. Guinea Pigs I

I -- -.- ?..-,.,.--.-

9. Non-human Primates '

10. Sheep 1 11. Pigs I -..----.-. ...--

12. CYher F a n Animals i ---

- - - - - . . - - -- - - . I

I C. Number of I D. Number ot anima. upon E. Number ot animals upon which teaching, expenmas, F. animals upon which exoerirnents. research. surgery or :esa were conducted involving which teaming, ! teaching, research. aceompanyng pain or aistress to the animats and for wt! research.

I s q e w . m taaa were me use of appropriate anesthetii. analgesic. or tnnqullb

expenmennls. or i c~nducted involving i drugs would have adverse!y affected me procetiures, res OF AN'MALS

tests were ' acmganyng pain or ' or interpretation of the teachng, research. experiments. I conduaed I distress to ?he animals an : surgery, or tests. ( An explanation of :he procedures [ ( COLUMNS involving no pain. for wnich appropriate 1 producing pain or distress in them mimais and t k r e a w c + 0 + E distress. or use o. / anesthetic. analgesic, w such drugs were not used must be attached to this repor! , pain-relieving tranquilizing drugs were . I drugs. used.

. - - - - I .-^ -.-- -- .... -- -.-- -----.. ..--.- ---.. -I- ".. - t I 26 I ---- I 26 -+-- , - -- --- - -. 62 I 62 - 119 I

I . .- ..- 119 ....... -..--.. --

0 i i 0 --.--..-- -----..----

14 1 - -...--- ----..+--

' 14

0 I i 0 --- -.,--Ad- -.... ---. - . . -

0 -.-- .- .-.-- ----.-... .--- --.- --.-... .. ..-.".-A t -

23 .

' 23 .-. - ----A -.---. - .- --

0 I .- ----------.. ---. +. .-- -.--.-.----.- --, ....----.----.----- 0

i - 13. Other Animals - --AM-

0 ! 0 T""-""-

I

1) Professionalty acceptable stancterds gcverning the care. treatment and use of animals, induding appmpriate use of anesretic: anaigesic, an0 tranquilizing drugs. prior to. during, and f o l l ~ n g acual rese~ teacn~ng, testing, surgery. or exoerimentatiw were followed by this researctr facility.

2) Each principal investigaior tras considered anernelives to painful proceoures.

3) Th~s :acility is adhering to h e standards and regulations under the Act, and it has required that exwtions to the Randards and reguiatio?~ be spegfiea and explained by the ~rlnclpal invesrigator anc: apg Institutional Animal Care and Use Committee (IACUC]. A summary of all such exceptions is attached to this annual report. In addition to idenxitying the IACUGappmW exceptions, this summar-/ in. Snef explanation of the excerrtions. as well as the species and number of animais affected.

4) The attending veterinarian for :his research facility has aCprocnate authority tc ensure the provision of adequate vetermary care and to oversee the aaequacy of olher aspects of animal care and use. -- --

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLfM OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

I DATE SIGNE5

( AUG 9' j ./

This ep.:n$s required by law (7 USC 2143). Fallure lo repon accoramg lo tne regulaoons can resul; In an order to cease and desist and to be subject to penalties as provided for in Sectlon 21:


I

- L

. REPORTING FACILITY ( List all locat~ons where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary ) I



FORM APPROVED OMB NO. 0579-0036

St Louis University 221 N. Grand Boulevard, Db-106 St Louis, MO 63103


Telephone: (3 14) -577-8345

FACILITY LOCATIONS ( Sites ) - See Atached Listing

C. Number of animals upon which teaching, research, experiments, or tests were conducted involving no pain, distress, or use o' pain-reliving drugs.

D. Number of animals upon which experiments. teaching, research, surgery, or tests were conducted involving acmmpnying pair- w distress to the animals an for which appropriate anesthetic. analgesic, or tranquiliring drugs were used.

E. Number of animals upon which teaching, experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for wt the use of appropriate anesthetic, analgesic, or tranquiliz drugs would have adverxdy affected the procedures, res or irlterpretaticln of the teaching, ?&>arch. exporinsnts, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animats end the reasc such drugs were not used must be attached to this repor:

B. Number of animal being bred. conditioned, or held for use in teaching. testing, expetimants, research, or surgery but not yc used for such purposes.

Animals Covered By The Animal

Welfare Regulations



4. Dogs - .--- - 1 5. Cats

6. Guinea Pigs I 7. Hamsters 7

9. Non-human Primates

lo. Sheep -- 11. Pigs

12. Other F a n Animals I -

I 13. Other Animals I

C h i n c h i l l a 1 2 ~ - L .

i Opossum

ASSURANCE STATEMENTS t

1) Professionally acceptable standards governing the care. treatment, and use of animals, including appropriate use of anestetic. analgesic, and tranquilizing drugs, pnor to. during, and following actual rese. teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and tegulatim be specified and explained by the prinapal investigator and apf Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual r e p a In addition to identifying the IACUC-approved exceptions, this summary in bnef explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL r or Legally Responsible Institutional Official )

DATE SIGNED

APHIS Form 7023 Site List

The following sites have been reported by the facility.

Registration Number: 43-R-0011 Customer Number: 1507 Facility: ST LOUIS UNIVERSITY

1402 S GRAND BLVD ST LOUIS, MO 63104 (31 4) 577-8345

SITE1 1402 SUTH GRAND BLVD ST LOUIS, MO 63104

2. Anheuser Busch Institute

3. Pediatric Research Institute

4. Macelwane Hall

This report is required by law (7 USC 2143). Failure to report according to the regulations can See reverse side for result in an order to cease and desist and to be s u w t to penalties as provided for in Section 2150. additional information.

Interagency Report Control No 01 BO-OOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOMER NO. ANIMAL AND PLANT HEALTH INSPECTION SERVICE 43-R-0015 1504 FORM APPROVED

OMB NO. 0579-0036

ANNUAL REPORT OF RESEARCH FACILITY 2. HEADQUARTERS RESEARCH FACILITY (Name and Adeess, as registered w8h USDA,

mdude Z& Code)

(TYPE OR PRINT) ST JOHN'S MERCY MED CTR 615 S NEW BALLAS RD ST LOUIS, MO 63141

I 3. REPORTING FACILITY (List all locations where animals were housed or used in actual research, testing, teaching, w experimentation, or held for these purposes. Attach additional

sheets if necessa~. \

ST LOUIS, MO 63141 I 1

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClUTY (Attach add&nd sheets if necessary or use APHIS FORM 702% )


Welfare Regulations

B. Number of animals being bred. conditioned, or held for we in teaching, testing, experiments, research, of surgery but not yet used for such purpoe~.

C. Number of animals upon which teaching, research, experiments, or tests were mduded involving no pain, distress, w use of pain- relieving drugs.

.. D. Number d animals upon

which experiments, teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic. or tranquilizing drugs were used.

E. Number of animals upon which teaching, F. experiments, research, surgery or tests were conducted involving accompanying pain or distress TOTAL NO. to the animals and for which the use of appropriate OF ANIMALS anesthetic.analgesic, or tranquilizing &ugs would have admety affected the procedures. results, or (Cola C + interpretation of the teaching, research, D + E) experiments, surgery, or tests. (An e@anatkn of the wwxdms producing pah or distress in these animals and the reasons such drugs w e not used must be a w d b this repon)

4. Dogs ,

5. Cats

6. Guinea Pigs - - - - - -

7. Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

11. Pigs 11 11

12. Other Farm Animals

13. Other Animals

Fenets 2 2

USURANCE STATEMENTS

1) Prof8ssionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anesthetic, analgesic, end tranquilMng drugs, prior to, during, and following actual research, teaching, testing, surgery, or experimentation were followed by this msearch facility.


3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all tba exaption, b attached to this mwl npoh In addition to identifying the lACUC-appmved exceptions, this summary includes a brief explanation ofthe exmpths, as well as the species and number of animals affected.


CERTIFICATION BY HEADQUARTERS RESEARCH FAClLlM OFFICIAL (Chief Executive Officer or Legally Responsible institutional oflicial)

I certify that the above is true, conect, and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL NAME & TITLE OF C.E.O. OR 1NSTITUTK)NAL OFFICIAL (Type or Print) DATE SIGNED

1 1 /I 4/2OO2 I I I APHIS FORM 7023 (Replaces VS FORM 18-23 ( ~ c t 88). which is obsolete PART 1 - HEADQUARTERS

(AUG 91 )

This repw! IS required by law (7 USC 2143). Failure to repwl according to the regulattons can resul: tn an order to cease anb des~st and to be subied to penalt~es as provided for in Seaion 21:



ANNUAL REPORT OF RESEARCH FACIUTY ( TYPE OR PRINT )

i. REPORTING FACILfTY ( List ail locations where animals were housed or used in actual research. test

1 1. CERTIFICATE NUMBER: 43-R-0021 FORM APPROVED OM6 NO. 0579-OX6


The University Of Health Sciences College Of Osteopahic Medicine 1750 Independence Ave Kansas City, MO 64106

Telephone: (816) -283-2000

--

I, or experimentalron, or held for these purposes. Attach additional sheets tf necessary ) I

Educational Pavilion FACILITY LOCATIONS ( sites ) - See Atached Listing

A. [ B. Number of animal i being bred.

conditioned, or Antmak Covered helC for use in

By The Animal teaching, testing, Welfare Reputations experiments,

; research, or 1 surgery but not yc

used for such

5. Cats

6. Guinea Pigs 0 -- -- -.- - ---..- 7. Hamsters 0 -. - .- -- 8. Rabbits i 0 --- .-.- .a. -- 9. Non-human Primates I 0 ---. ., - 10. Sheep - - . . . - -- - - A -.-A- ..- 11. Pigs 0 . . - - . .- - . - - 12. Other Farm Animals 0 - . ----... -. ---

C. NumWof i D. Number of animals upon animals upm i which experiments, which teaching, i teaching, research. research, ' surgery, or tests were

I experiments, or tests were conducted involving no pain, distress, or use a pain-relieving drugs. -- .-

0 .- .- .--

0 -- .--

conducted inwlvlng accompanying pain or distress to the animals an for which appropriate eneslhetic, analgesic, Or tranquilking drugs were used.

.-

E. Number of animals upon which teaching, experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for wk . the ure of a p ~ r o w t e anesthetic. a n a t g h or VanquIIiz ! TT#hFE,'" drugs would have adversely affected the procedures, res or interpretation of the teaching, research, experiments, '

surgery, or tests. ( An explanation of the procedures ( COLL&WS producing pain or d i m in these animals and the reasc C + D + E ) such drugs were not used must be attached to this repwl

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLlN f Attach additional sheets if necessarv or use APHIS Form 7023A \ I I

I

. -

-

-

-

. .

-

. ..

. -

-

L ) ASSURANCE STATEMENTS L 1

1) Professionaliy acceptable standards governing the care? treatment. and use of animals, induding appropriare use of anestetic, analgesic, and tranqullizmg drugs. prior to. during. and following actual re= teaching, testing, surgery. or experimentation were followed by tho research facility.

2) Eat5 principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and R h~ required that exceptions to the standards and regulations be specified and explained by me principal investigator end apg lnstitutianal Animal Care and Use Comrninee (IACUC). A summsry of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved excepiions, this summary in, brief explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research faa l i has appropriate author* to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects af animal care and use.

CERTlFlCAnON BY tlEADQUARTERS RES!ZARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional )

n

DATE SIGNED

APHIS FORM 7023 (Repbces VS FORM 18-23 (OCT 88). which is 0bsalete.j ( AUG 9; )

This re$d 1s requred D!, law (7 L'SC 2143). Failure to repon according to the regulations can resul: In ar, orae: 10 cease an: desist an5 tc be subject to penalties as orovided for in Section 21:

See attached Iom for additionat infamation.

Inreagency R e p p No.: . !



I. CERTIFICATE NUMBER: 43:R-0029 I FORM APPROVED OM0 NO. 05790036


Maple Woods Comm Coll 2601 Ne Barry Rd Kansas City, MO 64356

Telephone: (816) -437-3237


1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLlTY I Attach additional sheets if necessarv or use APHIS Form 70- 1 I A. 6. Number of animal

being bred, conditioned, or

Animals Covered ; held for use in Py Tho A n k a ! ' hsch!n,-. t~z f i . ?~ !

Welfare Regulations experiments,

j surgery but not ye used for such

-- - - - . . - . - , . . . -- , - , . . 6. Guinea Pigs t

.--- -. -- ..

I 7. H~msters

I --- ..-.-----

8. Rabbits

9. Nin-human Primates -... - -.-. 10. Sheep

I -- .-.-- - '

i -- . ..---. - ..... 11. Pigs . -. ..-....

12. Other Fam Animals :

- - G o a t s . I 13. Other Animals - . - -. .

ASSURANCE STATEMENTS

c. Number of animals upon which teaching, research, ex;.s.+me"ts, 3: tsstswere conducted invohring no pain, distress, or use cr pain-relieving drugs.

-. -..

D. Numbw of anlmals upon E. Number of animals upon which teaching. experiments. f. which experiments, research, surgery or tests were conducted indwng teaching. research, accompanying pain or distress to the animals and for wr surgery, or tests were the use d apptopriale anesthetic, analgesic. or tranquili

TOTAL NUMBER

%tX!i~C!d k ~ c k k g G:i;ps r h l d ha.<< ajvandiy sRe,?ed 3 e pr$c&ures, ies OF

! accompanying pain or 1 or interpretation of the teaching, research, experiments. I i distress to the animals an 1 sugary, or tests. ( AII exptanation of me p r~cedum ! ( COLUMNS . for which appropriate producing pain or distress in these animals and the reasc C + D + E )

anesthetic. a ~ l g e i c . or ! such drugs were not used rnusl be attached to this npo~ : tranquilizing drugs were used.

. . - _ . -.__ .--_ . . _ _ - _ .

41 4 1 . . . . - 31 t 1 3 1 i

I

'- 1 ---. - .--. . - . _ . - . .__ . I

- -. . pp -. --

1) Professionally acwtable standards governing the care. treatment. and use of animals, including appmpriate use of anestetic. analgesic. and tranquilizing drugs, prior to. during, and following actual re= teaching, testing, surgery, or experimentation were fallowed by this research fadliy.


3) This faciltty is adhering to the standards and requlations under the Act, and it has r e q u i d that exceptions to the standards and regulations be specfed and e*pUned by the principal investigatar and apC . lnstitutlonal Animal &-re and Use Commitiee ( I ~ u c ) . A summary of all such exceptions Is attached to this annual report. lnaddition to identifying the IACUC-apprwed exceptions. this summary in bnef explanation of the excepttons, as well as the species and number of animals affected.

4) The attendinp veterinaien for this resaarch facility has appropriate authority to ensure the provision of adequate veterinary care and to omsee the edequacy of other aspects of animal care and use.

CERTtFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executjve Officer or Legally Responsible lnstitutio~l Official )

I NAME & TITLE OF C.E.O. OR lNSTlTUf ION& OFFICIAL ( Type of ?rinl)

DATE St NED I olete.)

Y ~h:s rc:Nrl IS requ~red by law (7 USC 2143). Failure to report accordmy to Ihe regulations can result in an order lo cease and desist and l o be subjecl lo penall~es as provided lor in Secliacr 23513

UNITED STATES DEPARTMENT OF AGRlCULTURE ANIMAL AND PLANT HEALTH lNSPECT1ON SERVICE

See reverse side lor Interagency Repor1 Control No additional in!orrr~aliori 01 80-WA-AN

1. REGlSTRAnON NO. Ptre+ k I FORM APPROVED U U Y C a l r

43-R-0029 1488 I OMB NO. 0 5 7 ~ 0 3 6 2. HEADQUARTERS RESEARCH FACILITY (Name and Addross, irs reaistered with USDA

include Zip Code)

CONTINUAT ION SHEET FOR ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT) I Maple Koods Comm Coll 2601 Ne Barry Rd. Kansas C i t y , MO 64156

I

REPORT OF ANIMALS USED BY OR UNDER CONTROL O f RESEARCH FAClLlN (Attach oditlitiontrl sheets 11 ~ ~ s c e s s a w or use this lornt I

A 6. Nu~nber ol t sn~mals beir~y

Animals Covered bred, By The Animal cond~lmned, oc

Weltare Regulations held for use ~n teachlny, testing. experiments,

- - - - - - - - - - - - - - - - - - q research, w suryefy but no1

12. &/OR 13. Other yet used lor such (bs t by species) purposes.

I ASSURANCE STATEMENTS

: Number of art~rnals upon which leaching. research. enpwmeols, or tests were cor~ducled invalvlng no parn, disltess, or use ot pain- relieving drugs.

D. Number al animals upon wh~ch ewperirnenrs. teaching. research. suryery, or tests were conducted iovolvhg accompilnylng p ~ i n or dislress to the anirnals and tor which appropriale aneslhelic, a~~alyesic, or Iranqu~llzing drugs were used.

E. Number 01 animals upon which leachhy, experimctnls. research, surgery or tests ware conducled involving accumpilnymg pain or distress l o tho animais and lor which Ihe use ot approprlare anesihelic, analgesic, or tranqu~lizing drugs would have adversely atfecred the procedures, results, or intetprelation ot the teaching, research. experiments, surgery, or tests. (An explanation of the prociufures producing pain or distress in these animals end the reusons such drugs were not used must be aftached lo this report)

TOTAL NO. OF ANIMALS

(Cols. C + D + E)

1 ). Professionally acceplable slarbdards governing the care, trealrnenl. and uso of anitnols, iclcluding approriale use of a~leslhtttic, analyt?.jic, and lra~rquiliz~ng drugs, prior lo, during. and iollowi~ig aclual research, teach~ng. tesling, suryery. or exper~rnentalion were lullowed by this research Iacilily.

2) Each principal irwesrigalor has considered alter~batives to paintul procedures.

3). This facility is adhertrig to the slarbdards and reyulotior~s under rho Acl, arid il has required thal exceptmns lo the slandards and reyulations be spm~lied and explained by the principal investrgalor and approved b y the l ~ ~ s l i i u l i o ~ ~ a l An11nu1 Care ar~d Use Corivnillce (IACUC). A summary of all such exceptions is atlached l o this annual report In additlon l o identitying the IACUC-approved excepllons, lhis summary incllldes a hr~ef explanairus 01 Iha oxcopllcrris, as well as lhe specles and number of anlrnals allotted.

4). The allending velerirtar~an lur this research facilily has appropr~ale aulhorlly lo eilslrre Ihe provision ol adequate velerinary care and to oversee the adequacy o l ulher aspects of animal care and use.

- -

CEH11FICATlON BY HEADQUAHTEY HESEAHCfl FACILITY OFFICIAL (Chief Executive Offker or Legally Responsible institutional Official)

I cerl~ty l hat the dbove IS Iruo. correcl, artd complete (7 U.S.C Seclron 21 43) t

; DATE SIGNED

This report is required by law (7 USC 21 43). Failure to report according to the regulations can See mwne side for result in an order to cease and desist and to be subject to penalties m provided for in Section 2150. additional information.

m e n c y Report cofm No 01 60-DOA-AN . .

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REOlSTRAT10N NO. CUSTOMER NO. ANIMAL AND PLANT HEALTH INSPECTION SERVICE ~~~~~ I304 FORM APPROVED

OMB NO. 05794036 m

ANNUAL REPORT OF RESEARCH FACILITY m

hdude ZQ Code)

(TYPE OR PRINT) TRUMAN STATE UNNERSTTY SCIENCE DIVISION 262 SH KIRKSVILLE, MO 63501

I

3. REPORTING FACILITY (List all locations where animals were housed or used in actual research, testing, teaching, or expsrimentation, or held for these pwposes. Attach additional sheets ~f necessary.)

FACIUTY LOCATK)NS(sites) SITE I I KIRKSVILLE, MO 63501 I

I

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attad, sddllknel sheets c?nebessasy or use APHIS KlRM 702U)


Welfare Regulations

B. m w o f animals being bred, conditioned. or held for use in teaching, testing, expahents, research, or surgery but not yet used for such PlJrposes.

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters I

8. Rabbits

9. Nan-Human Primates

10. Sheep


13. Other Animals

s ASSURANCE STATEMENTS

animals upon which experiments, which teaching. teaching, research, research, wrgery, or tests were experiments, w conducted invdving tests were a!=VaWm Pain or

distress to the an lds invdving no and for which m a t e

use of pain- tranquilizing clruge were

axperiments, research, surgery or tests were conducted invohring accompanying pain or distress TOTAL NO.

anesthetic,analQesic. or tranquilizing drugs would (Cob. C +

animals and ~ reasmisuch dhrgs wsre not used must be an8clmd to tth qmij

1) Rof655ionally acceptable standards governing the cam, treatment, and use of animals, induding appropriate use of anesthetic, analgsdc, and tranquilizing dnrgs, prior to, during, and following actual research, teaching, testing, wrgcwy, or experimentation were fdlowed by thls resesrch facility.

2) Each principal investigator has considwed alternatives to painful procedures.

3) This faclllty is adhering to the standards and regulations under the Act, and it has required that ~xcepticns to the standards and regulations be specified and eqMned by the principal investigator and approved by the Institutionel Animal Care and Use Committee (IACUC). A rummrry of 8II the oxceptlom b rttrched to thk rnnwl npah In addition to identifying the IACUGapproved Eucceptions, this summary indudes a brief explanation of the exceptions, as wdl as the spades a d nudm of enitnalt? affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequecy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL (Chief Executive Officer or Legally Responsible lmtitutional official)

I certify that the above is true, conect, and complete (7 U.S.C. Section 21 43) . SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Prlnt) DATE SIGNED

1 1/04/2002

APHIS FORM 7623 (Repbcw VS FORM 18-23 (Od 88). which h ob.okte PART 1 - HEADQUARTERS (AUG 91 )

See attached form for addittonal information.

Interagency Report jyp' %s r$lrl is required by law (7 USC 2143). Failurn lo repm according to the regulations can result in an order to cease and desist and to be subject to penalties as provided for in Seeion 21!

UNITE5 STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

7-

-

- 3. REPORTING F A C I W ( Lisl all I~cattons where animals were housed or used in actual research, testing, w experimentation, or held lor these purposes. Attach additional sheets if nL9cssary )

FAClllTv LOCATIONS ( Sites ) - See Atached tisting

- --

1. CERTIFICATE NUMBER: 43-R-0031 I FORM APPROVED OMB NO. 05794036


C C D Jefferson County 1000 Viking Dr Hillsboro, MO 63050


Telephone: (636) -797-3000

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets If necessaw or use APHIS Form 7023A 1 I 8. Number of animal

being bred. conditioned, or hdd for use in teaching, testing. sxpehats, research, or surgery but not yt used for such wm=.

C. Number d animals upon which leaching, research, sxper3nents, or tests *&-a conducred involving no pain. distress, or uss u pain-relieving drugs.

0. Number of animals upon which experiments. teachtng, research, surgery, or tests wera ccnduaed Involving accompanying pain or distress to the animals an for which appropriate anesthetic. anaigesic, or Vanquilizing drugs were used.

E. Number of animals upon which teaching. experiments. rasearch, surgery w tests w e n conduded involving accompanying pain of distress to the animals and for wr I the use of aPPrOptiat0 anesthetic, a~lgesic, or tranquik drugs would have adversely affected the procedures. res ur interpretation of the teaching. reseam. exparlmeftts.

( surgery. or tests. ( An ap fana th of the procedures

I producing pain or distress in these animals and the reas such drugs were n d usad myst be attachea to this repor'

F. b



Animls Covered By The Animal

WeMae Regulations

4. Dogs I

6. Guinea Pigs I t

7. Hamsters I I

8. Rabbits I 9. Non-human Primates

10. Sheep

I I

I I. Pigs


13. Other Animals I


1) Prolesstonally acceptable standards governing the care. treatment. and use d animals, including appropriate use of anestetic. analgesic, end hanquilizing drugs, prim to, during. and following ectual resrr; teacning, tosting, surgery, or experimentation were followed by this research facility.

2) Each principal investgator has ronsidereU alternatives ta painful procedures.

3) This facility is adhering lo the standards and regulations under ths Act, and il has required that exceptjon~ to the standards and .regulations be sped& and explained by the principal investigator and app Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to thb annual report. In addition lo Identifying Vle WUC-appmvecl exceptions, this summary in1

brief explanation of the excegticns. as well as Ihe species and number of animals affected.

4) The attending veterinarian far thrs resea& fadlity has appropriate authority to ensure the pnvision of adequate wtsrinary care end to wrrsee the adequecy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

1 DATE SIGNED

i ,&L~ / -

This report is required Dy law (7 USC 21433. Failure to reporl accordin9 to the regulations can result in an order to cease and deslst and to be subtect to 0enai;les as provided for In Sectior. 21:

See anached form for additional infomatron.

Interagency Report ~ P ~ ! L H - -

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HENTH INSPECTION SERVICE


I. CERTIFICATE NUMBER: 43-R-0036



Little Creek Farm Inc Po Box 291 1 Leslie, MO 63056

Telephone: (573) -484-3085


-- 1 REPORT OF ANIMALS USED BY OR UNDER CONTROL 6 RESEARCH FACILITY ( Attach additional sheets If messarv or use APHIS Form 7023A \ I


Welfare Regulations

6. Number of animal being bred, conditioned, or held for use in teaching, testing. experiments. research, w surgery but no1 y~ used for such purposes.

4. Dogs I - ..... - . . . ---. . 5. Cats I

I I- . .- . . -! . - .-

6. Guinea Pigs

7. Hamsters

8. Rabbits -0- J

-.- --.. ,. .-, .--. , .

i 12. Other Farm Animals I

36 . A o a t s ---- - 13. Other Animals i

-.- I 1 t

I


C. Numberof : D. Number of animals upon E. Number of animals upon which teaching, experiments, [ F. animals upon which teaching, research. experiments, of tests were conducted involving no pain, dwtress. or U s e Q

pain-relieving drugs. - - ..-

which experiments. teaching. research. surgery, or tests were conducted involving accompanying pain or disfress to the animals an for which appropriate anesthetic. analgesic. or hanquilizlng drugs were used.

-.- . --- -

research, surgery or tests were conaucted indving j accompanying pain or distress to the animals and for wt ' the use of appropriate anesthetic, analgesic. or tranquiliz '

NUMBER

drugs would haw adversely affected the procedures. res OF

or interpretation of the teaching, research. experiments, 1 surgery, or tests. ( An explanation of the procedures ( COLUMNS

produang pain ar distress in these animals and the reasr C + D + E ) such drugs were not used must be attached to this reporr '

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs. prior to, during. end following actual r w e ~ teaching. testing, surgery, oc experimentation were followed by this rasearch facility.


3j This facility is adhenng to (he standards and regulations under the Act, and it has required that exceptions to the Standards and regulations be wecified and explained by the principal tnvestigator and apF Institutional An~mal Care and Use Committee (IACUC). A summary of all such exceptions fa attached to this annual report. In addition to ~dentifying the LACUC-approved exceptions. this summary in. bnef explanation of the exceptions, as well as the speaes and number of anlmals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care an6 to oversee the adequacy dother aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLlrY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

SIG 1 DATE SIGNED

[ AUG 91 )

APH

11-22-0

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR P R I M )

1. CERTIFICATE NUMBER: 43-R-0037 I FORM APPROVED OM0 NO. 0579-0036


Central Mo State Univ Wcm Science 306 Warrensburg, MO 64093

Telephone: (81 6 ) -543-4933

I I

3. REPORTING F AClLlTY ( &st all locations where arurnak were housed w used m actual research, testng. or expenmentatm, or held for these purposes. A M add~tional sheets if necessary ) I

-

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHtS Form 702- 1 1

Anbruh Covered By The Animal

Welfare Regulations

1 6. Number of animal being bred. conditioned. ff hdd for use in teaching, testins. experimenk. research, or ~rgerybutMF used for such purposes.

5. Cats

'. Hamsters I I. Rabbits

I. Other Animals

r o u n d Squirrel 0

?er Mouse 1 0 4SSURANCE STATEMENTS

C. Nwnberd animals upon which leaching. -d. experiments, w lestswere mnducted invdving no pain. distress. or use v p a M i drugs-

D. Number d mimats upon which experiments. leaching, research. swgery. atestswere conduded inMhring ==wanyin9 pain dies to the animals an f a which appmpriale amsthetic. andgesic, or tranquilking drugs were wed.

E. Number of animals upon which teaching, experiments. I research. surgery or tests w e -ctd irndving 1 F- ampany ing pain or distress lo the animak wd-kwh the use of appcopriak anesthe(ic, analgesic, or banguilii drugs would have adverse)v affected the wocedues. res

1 1) Menionally acceptaMe standards gweming the care, treatment and use d animals. induding appropriate use of d e t i c . analgesic, and tranquilizing drugs. prior to, during. and foliowing actual re.&

teaching, testing. surgery, or experimentation were followed by this research facility.

2) Each principal invesligator has considered alternatives to painful procedures.

3) This f a d l i is adhering to the standards and fegublions under the Ad, and it has required that exceptions to the standards and regubtiars be spedkj and explained by Lhe principal investigator and apr lNtitutional Animal Care and Use Committee (IACUC). A sumnay of dl such exceptions is attached to the annuaf nport In addition lo identifying the IACUCappmHed exceptions, this summary ir, brief explanation of the excxpbons. as weR as the spedes and number d anknak affected.

4) The allending veterinarian for this research faullty has appropriate authority to ensure the provision of adeguate veterinary care and b oversee the adequacy dl other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Exewtive Off- or Legally Responsible 1nstiMional official)

DATE SIGNED

i(

PHIS FORM 7023 (Replaces VS FORM 18-23 (OCT 88). which is obsolete.) (AUG 91 )

I Thll repor! IS rqu i r cd by law (7 UY: 2143) Fatlure to report ucocd~ng l o the regulations can result in an order to cease and desist and lo k subject lo penalties JS providcd lor in Section 2150.

See reverse s& lot m m r w n c y ncport uwtroc mu.

additional inlormatton. 0180-WA-AN -

1. REGISTRATION NO. FORM APPROVED OM6 K) 0579-0036

2. HUDOUARTERS RESEARCH FAClLIM (Name and Address, as rcgtstered wrth US04 rnchde ZIP Code)

c Number animals upon which teaching. research,

.- enpcrirnents, or tests were, '

conducted anvdvmg no pan. distress. or

: . use ot pain- .: .. relied% drugs.

D. Number ot animals upon which expenmenis. teaching. reseatch. surgery, or ta ts were. conducted involving accompanying pan or dislress l o the animals and lor which appropriate anesthetic, a n a w c . or tranquilizing drugs were ' used.

ssary or use this lorm.)

5 . Number ol animals upon which leachlq. expertrynts. research, surgery or lests were

F

conducted invoking accompanytng pain or distress to the animals and lor whtch lhe use ol appropriale TOTAL NO. anesthetic. analgesic. or- tranquilizmg drugs would OF AN~MAL~

- have adversefy affected the procedures. results. or interpretalion ot the leaching. research. experiments, surgery, or lests. (An explanation d ( ~ 0 1 ~ . c + the procedures producing pain or distress in these . D + E) . . animals ~d @e reasons such drugs were not used. : mud be etfeched to this report).

1). Protessiocrally acceptable standards governing the care. trealrnent. and use of animals. including apprwiate use of anesthetic. analgesic. and tranquilizing drugs, prim to, during. and tdlowing actual research, teachtng. lesling, surgery. or experimentation were Idlowed by this research lacilily.

2). Each principal invesligator has consideted alternatives to pain(@ procedures.

3). This facility is adhering to the standards and regulations under the Acl, and it has required that exceptions l o the standards and reguhtions be specilied and explained by the principal invesligator and approved by the Institutional Antmal Care and Use ~ m i i t e e (IACUC). A S U m m l y 0l all such exceplions is attached to this annual report. In addition to identitytng the IACUC-approved exceptions, this summary includes a briet explanation 01 the exceptiom, as well as the specter and number at animals alfected.

4). The attending veterinarian tor lhls research taciltty has appropri~le authority lo ensure the provision 01 adquale veterirwry care and to oversee the adequacy o l other aspects 01 animal care and use.

CEHl'XF'ICA'I'ION BY HEADQUARTES RESEAKCIi FACIUTY OPPICIAL (Chief Executive Officer or Legally Responsible Institutional Official)

I certlfy that the above is true. correct. and compkte (7 U.S.C. Section 2143).

SI 1 DATE SIGNED I

This repcrt is rewired by law (7 USC 2143). Failure to reporl according to the rqulerions can result ic an I ier to cease and deust and to be subject to pena!!ies as brovlded for in Section 21:

UNITED STATES DEPARTMENT OF AGR1CUlTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE


See attached form for ke+? control NO.: addi:iona! information J

1. CERTIFICATE NUMBER: 43-R-0041 I FORM APPROVED OMB NO. 0579-0036

CUSTOMER NUMBER: 14 16

Central lnst For The Deaf 4560 Clayton Ave St Louis, MO 631 10

Telephone: (31 4) -977-0221

i

,. REPORTING FACILITY ( List ali locat~ons where an~mals were housed or used in actual research, testing. or experimentation. or he:d for these purposes. Attach additional sheets if necessary )

FACILITY LOCATlONS ( Sites ) - See Atached Listing

-

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I A. 1


Welfare Regulations

--. -- 5. Cats

-,

6. Guinea Pigs

6. Number of animal being bred. conditioned, or held for use in teaching, testmg, expwiments, research, or surgery but not yc used for such puw-.

- - .- - - . . - - * . 7. Hamsters

. . ... ... .....

8. Rabbits - --, .- - ,

. - - . - 1. . - - 10. Sheep

" . _

1 1. Pigs -. -. .-- ....

12. Other Farm Animals 1-

13. Other Animals I

... P... . --- .--..

Gerbils 2 7 .... t ASSURANCE STATEMENTS

C. Number of . D. animals upon ' whim teachmg, :

research, experiments, or i tests were !

conducted involdnp no pain. i distress. or use o paiwdieving drugs.

.-.-, - --! -

Numberofanimalsupon E. which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals an for which appropriate anesthetic. analgesic, ar i tranquilizing drugs were . used.

, . -. . . -

Number of animals upon which teaching, experiments. ' F. research, surgery or tests were conducted involving : accompanying pain or distress to the animals and for wP i

the use of appropriate anesthetic. analgesic, or tmnquiliz a NUMBER

drugs -Id have adversely affscteu the procedures. res OF

w interpretation of the teadrlng. ressen31, experiments, ; surgery, or tests. ( A ~ I explanation of the procedures . ( COLUMNS produdng pain or distress in these animals and the reesc C + D + E ) such drugs were not used must be attached to this reporl .

1) Professionally acceptable standards governing the care. treatment. and use of animals. induding appropriate use of anestetic. analgesic, and tranquilizing drugs. prim to, during, and following actual rase; teaching. testing, surgery, w expenmentation were followed by thrs research facility.

2) Each principal investigator has considered akematives to painful procedures.

3) Th:s facility is adherrng to the standards and regulations under the Act, and it has required that exceptions to the stanaards and regulations be wecified and explained by the principal investigator and apt Institutional Animal Care and Use Committee (IACUC). A summary of all such e*ceptiona is attached to this annual report. In addltion to identifying the IACUC-approved exceptions. this summary in. brief explanation of Me exceptions, as well as the species and number of animak affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adeguacy d other aspects of animal care and use.

CERTlF ICATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ficer or Legally Responsible Institutionat Official )

NAME 8 T l n E OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print) I E-D 4 c ~.,;/i .

APH ( AUG 91 )

ANNUAL REPORT OF R E S M C H FACILITY ( W E OR PRIM) I 222 S Woods Mill Rd Ste 400 Tel8p hone:

(31 4)542-2228


qT3

). which b 0bwkM.) A /

Curt ID: 1402


Thls report is required by law (7 USC 2143). Failure to reporl according to the regulations can See attached form for Interagency Reporl Control No.:

result ir. an order lo cease and desis! and to be subject to penalties as provided for in Section 21: additional inforrnatm.

University Of Missouri-St Louis Office Of Research 8001 Natural Bridge St Louis, MO 63121

I Telephone: (3 14) -5 16-5928



I

i. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, of held for these purposes. Attach add~rional sheets if necessary j

1. CERTlFlCATE NUMBER: 43-R-0046


. - . -. -- . -

FACILITY LOCAT IONS ( Sites ) - See Atached Listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY 1 Attach additional sheets if necessanr or use APHIS Form 7023A 1 I A. I 8. Number of animal I being bred,

conditioned. or Animals Covered held for use in

By The Animal teaching. testing, Welfare Regulations ! experiments,

surgery bul not yr used far such

. -. ..--

4. Dogs I f - . . . - , - - . - . - - - - . 5. Cats

-- .--. .-- .-.. --- 6. Guinea Pigs

I

'

--I-

9. Non-human Primates -.--.-.

10. Sheep I

I

--.

- ..-- .-- .-. P. - 13. Other Animals 1 I

. . . . . - I-. _ Voles

C. Numberof I D. animals upon which teaching. research. experiments, or . tests were 8

conducted involwng no pain. distress, or use o pain-relieving drugs.

Number of animals upon which experiments. teaching, research, surgery. or tests were conducted involving accompanying pain or distress to the animals an for which appropriate anesthetic, analgesic, or tranquilizing drugs we*, used.

-.-

E. Number of animals upon which leaching, experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals end far wt the use of appropriate anesthetic. analgesic. w tranquiljr drugs would have ~dversely affected the procedum, res .

a or interpretation of the teaching, research, experiments, surgery, or tests. ( An explanation of the procedures prnducing pain or distress in these animals and the reasc

f such drugs were not used must be anached to this repar



I

ASSURANCE STATEMENTS I

1) Professionally acceptable standards governing the care! treatment, and use of animals, including approprjete use d anmetic, analgesic, and tranquilizing drugs, prior to. during, and following actual rese: teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal investigator has cansidered atternatives to painful procedures

3) This facility is adhering to the standards end regularions under the Ad. and it has repurred that exceptions to the standards and regulations be slmifieo and explained by the principal investigator and apF Institutional Anima! Care and Use Committee (IACUC). A summay of all such exceptions is attached to this annual repoh In addition to identifying the IACUC-approved exceptions, thrs summary in brief explanat i~ of the exceptions, as well as the species and number of anirnels affesed.

4) me attending veter~narian far this research facility has appropriate authority to ensure the provision of adequate vetennary care and to oversee the adequacy of other aspects of animal care and use.


Print) DATE SIGNED

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PUNT HEALTH INSPECTION SERVICE


University Of Missouri-Kansas-Kansas City Office Of Research Admin 51 00 Rockhill Rd Kansas City, MO 641 10

Telephone: (81 6) -235-168 1

C I Volker Campus

FACILIR LOCATIONS !' S~tes j - See Alacnw Listing H o s p i t a l Hill Campus Labora to ry Animal Center Laboratory Animal Center

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACIL:TY ( Attach additional sheets if necessaw or use APHIS Form 7023A 1 I A. ] 6. Numwr of animal

I being brea. 1 conditioned. or

Anifnab Covmd heid for use in 3y FIT Animal . tnacntn~ !eg::.y.

Wethre Regulatbm sxoenments, j reseaTch. or ! surgery but not yt

usea for sum

I

4. Dogs I

!

5. Cats

6 . Gcrinea Pqs

9. Nonhuman Pnmates

10. Sheep I

11. Pigs I - --

12. Other Farm Anmais j

C. Number of anfmals upon which teacning, reseam. BXPBlCfPllF. 07

lests were CmduCtM involving no p a n distress, or use u paamiew ng drugs.

: D. Nurnoer of an~mals uoan ; micn expenmenls. I teacnmq, mearch. ! surpay. or tests were

=:9niictw inwlvmg ammpanylng paln or d i m e s to the anmals an for wnlcn amroonate aneslhetlc, analgesic. or j tranquiiimg cmgs w e

] Uwd.

APHIS FORM 7023 (ReDla- VS FORM 78-23 [OCT 88). wn~ch rs 00S0(me.)

C i

( AUG 91 )

CERTlFICATlON BY HE4DQUARTERS RESEARCH FACILITY OFFICIAL i Chief Executive Officer or Legally Responsible lnstitutianal Oftidal ! I

This report IS required by Iavi (7 USC 2143:. Fa:I~re to repM accordtnc to the regulations can result in an order to cease and desist and tc be suYec! to penalies as pmvlded for n Section 21f

See attached form for add11ionai lnfonatim

lnteragw(cy Pdpc$f Control No.: . . - --



1. REPORTING FACILITY ( Us: all locations where animals were housed or used in actual research. tesl




Royal Canin U.S.A. 5600 Mexico Rd Ste 2 St Peters, MO 63376

Telephone: (573) -364-1 312

, or expertmentatlon, or held for mese purposes. ~ttachaddltlona! sheets if necessary ) I


-- --

EPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I

Animals Covered By The Anlmal

Welfare Regulations

B. Number of animal being bred! conditioned. or held for use in teaching, iesting, experiments, research, or surgery but not yt used for such PurP-.

4. Dogs -. ---. 3 . . - -. I - 5. Cats . .-

0-w .. ---.. , -.--- - 6. Guinea Pigs t - .. .- ." ..-- .

7. Hamsters I - . . . . P. -.--

8. Rabbits 1 -.,

9. Nonhuman Primates I ' ' ' - -t

.... .--

10. Sheep i I

1 ASSURANCE STATEMENTS

C. Numberof animals upon which teaching. research, experiments, of tests were conducted mvolving no pain. dlstfess, or use a pain-relieving drugs.

D. Number of animals upon : whtch experiments, : teaching. research,

surgery, or tests were i conducted mvolving

accompanying pain or 1 distress to the animals an

for which appropriaie : anesthetic, analgesic, or : mnquillzing drugs were

used.

E. Number of animah upon which teaching. experiments, F. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for wk lhe use of appropriate anesthetic, analgesic, or tranquilu TOTAL NUMBER

drugs would have adversely affected the procedures, res OF

or mterpretatian of the teaching, mearch, experiments, surgery, or teats. ( An explanation of the procedures ( COLUMNS producing pain or distress In these animals and the reast C + D + E ) such drugs were not used must be attached to this repan '

1 ) ~rofessionel l~acce~tab~e standards governing the care, treatment, and use of antmals, including appropriate use of anestetlc, anaigesic. and ttanqublizrng drugs, pnor to, dunng, and followrng actual rese teaching, testmg surgery. or expenmenlation w m followed by this research fac~ltty.


3) This facility is adhering to the smdards ana regulations under me Act, and it has required that exceptions to tha standams and regulations be specified and explained by the prinwpal investigator and apF Instirutronal Animal Care and Use Cornminee (IACUC). A summery of a l such exceptions Is attached to thfr annual report. In addition to identifying the LACUGapproved exceptions, this summary in1 bnef explanation of the exceptions, as well a5 the species and number of animals affecied.

4) The attending veterinarian for this research facilrty has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use


(

TITLE O f C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or DATE SIGNED

099 -84 APHI .j


This report is required by law (7 USC 2143). Failure to reporl according lo the rngulations can See attached form for In t t rapq **pofl Lontrol No.:

rcsut .:.an order to cease and desist and ro be subject to penal!ies as provioed for h Section Zl! additional information. r 7. .,., t r...,,

lmrnvac Inc 6080 Bass t n Columbia, MO 65201

I

. REPORTING FACILITY ( List ail locations where animals were housed or used in actual research, testing. or experimentabon. or held for these purposes. Attach additional Sheets if necessary )



FACILITY LOCATIONS ( Sites ) - See A tamd Listing



REPORT OF ANIMALS USED BY O R UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I I

A. 6. Number of animal 1 being bnd. ] conditioned, or

Animals Cwered held for use in By The Animal teaching. !esting.

Welfare Regulations experiments. research, or surgery but not yf used for such purposes.

- . - - - . 4. Dogs

..... -- .- .--

- - - -

1 5. Cats

.-- I . 7 - 6. Guinea Pigs - - - - - - ... +--.

7. Hamsters

8. Rabbits -- ...... --

9. Non-human Primates 1 . . . ..... - 10. Sheep I 1‘ ..... .+., . -.

11. Pigs I ---, 4 - -

12. Other Farm Animals I 1 13. Other Animals I I

C. Number of animals upon which teaching. research: expwimmts, or

tests were conducted involving no pain, distress. or use ti pain.rdieving drugs.

.- . . -.-

, D. Number of animab upon I which experiments.

teaching. research.

z ~ ~ d u c e d invdving accompanying pain or distress to the animals an. for which appropriate anesthetic, analgesic, or tranquilizing drugs were used.

.

I E. Number of animals upon which teaching. experimenls. I research. surgery or tests were conducted involving ! accompanying pain or distress lo the animals end for WF

the use of appropriate anesthetic, an&lgesIc, or tranquitiz ' d%.;SS wwld k i e adv2'a:S61y aYacl6d t k priI&~idS, 1-

or interpretation of the teaching. research, experiments. surgery, or tests. ( An explanation of !he procedures pmducing pain or distress in these animals and the reasc such drugs were not used must be attached to this repm


( COLUMNS C * D + E )


1) Professionarly acceptable standams governing the care, treatment: and use of animals, including appropriate use of anestetic. analgesic, and tra~uil izing drugs, prior to. during, and following actual rese; teaching, testing. surgery. or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the pnnclpal investigator and apF Institutionel Animal Care and Use Committee [IACUC). A summary of all such exceptions is attachecl to this annual report. In addition to identifying the IACUC-approved exceptions, this Summary in, bnef explanation of the exceptions, as well as the species and number of animals effected.

4) The attending veterinarian for this research facihty has appropnate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.


S 1 DATE SIGNED

AP

).' . - p 3 ( . d

I w &an w requveo by wv u x , L v w j . pawre 10 repon acmromg 10 me reguatlons can result in an order to cease and desist and to be subkd to Denalies as ~rovided for in Section 21!

-* "...a"' IC." 1"'111 ."l

additional information. . . - . -. -



1. CERTIFICATE NUMBER: 43-~-0052 I FORM APPROVED OM0 NO. 05790036

CUSTOMER NUMBER: 1 5 13 I 3. REPORTING FAClUrY ( tist all locations where animals were housed or used in actual research. testing, or experimenration, or hcu for these purposes. Attach aoditimal sheets if necessary ) I

S W Missouri State Univ 901 S National Ave Springfield, MO 65804

Telephone: (41 7) -836-5972

REPORT OF ANIMALS USED BY OR UNDER I

Anirnab Covered By The Animal

Welfare Regulations

B. NumberdanimJ being bred, conditioned. or held for use in teaching, testing, experiments, raS6arCh. or surgery but not yf used for such

FAClLlTY LOCATIONS ( Sites ) - See Atached Listing

:ONTROL OF RESEARCH FACILITY I Attach additional sheets if necessanr or use APHIS Form 7023A I 1

6. Guinea Pips

I I

I -.+--------- ----.

i 7. Hamsters I i t U)II.[ 9. Nonhuman Primates

10. Sheep ----

12. Other Farm Animals ""__C__t . Cattle 1 O 1- 13. Other Animals

I

C. Numberof animals upon which teaching, research, experiments, or tests were conducted involving no pain. distress, w use CY

pain-relieving drugs.

D. Number of anbnals upm which experiments. teaching, research. surgery, or tests were conducted invdving accompanying win or dishss to the animals an for whkh ammpriate . . .

anesthetic. analgesic, or tranquilking drugs were used.

E. Number d animals upon whkh teaching, experiments, research, surgery or tesls wefe conducted involving accompanying pain or distress to the animals and for* the use of appropriate anesthetic, analgesic, or tranquiliz drugs would have advarsely affected the procedures. n# or interpretation of the teaching, research, experiments, surgery, or tests. i A I -;W &on oi he proadores producing pain or distress in these animals and the teas such drugs were not used must be attached id this repar:

F.



teaching, lesting, surgery, or experimentation were followed by this research fadli .

Little Brmm -.---


m

0

3) This facility is adhering to tha standards and regulations under the Act, and has required that exceptions to the standards end rwuiat im be specifled and explained by the principal inve~tigat~r and aPF Institutional Animal Care and Use Committee (WCUC). A s~~wnnary of all such exception# is altached to this annual report. In addition to idenlifymg the IACUC-approved exceptions, this Summary ina bnd explanation of the excefptions, as well as the species and number of animals affected.

4) The attending Veterinarian fw this research facititv has awroDriate author* to mure the provision of adeQuale veterinary cam and to oversee the adequacy of omer aspects of animal care and use.

P i ~ i s trelle I 0

0

CERTIFICATION BY HEADQUARTERS RESEARCH FAClUTY OFFICIAL I

I

( Chief Executive Offcer or Legally Responsible Institutional Official ) I

ASSURANCE STATEMENTS 1

1) Professionally acceptable standards gaveming the care, treatment, and use of animals. induding appropriate use of anestetic, analgesic, end tranquiliring dmgs, prior to. during. and fdlawing actual rese:

DATE SIGNED

1. REGISTRATION NO.

1). P l ~ f e S s t ~ n ~ l l y acceptable slandards governmg the care, trealment. and use ol animals, including approriate use of aneslhelic. analgesic, and trnnquilizing drugs, prior lo. durlny. and l0 l l 0~ ing ac lw l research, leochmg. testing, surgery, or experirnenlalion were lollowed by lhis research Iacilily.

I


~ h l s report is required by law (7 USC 2143). Failure lo report according lo the regulalims can See revam side lw lnlera~ency Rapor1 Control Nn

resdl in an order to coase and desisl and to be subject lo penalties as provided lor in Section 2150. additional ifilormolion. 0 I BO-MA-AN

2) Each principal invesligalor has considered allemaLives to. painlul procedures.

2. HEADOUARTERS RESEARCH FAClLlTY (Name and Address. as registered with USD4 includo ZIP Code)

Southwest Missouri State University 901 South National Avenue Springfield, MO 65804

Phone: (417) 636-5972

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTfON SERVICE

CONTINUATION SHEET FOR ANNUAL REPORT OF RESEARCH FAClLlfY

( TYPE OR PRINT)

3). This tacility is adhering l o the srandards and regulal~ons under the Acl. and it has required that elcceplions lo the slandards and regulations be specitied and explairied by the principal invesligalor and approved by the I1istituiiotcj4 Amma1 Care and Use Cornmilfw (IACUC). A summary of all such e ~ ~ e p l i o n ~ is altached to this annual report. In addilion lo idenlilymg the IACUC-approvud exceptions. \his summary inctudes a brief axplanation ol the exceplions, as Wel as Ihe species ~ n d number o l anlrnak altecled.

41. Tha allending veterillarier! tor this research facdity has appropriale aulhorily lo ecnure the provision o l odequnle velerir~ary care a~rd lo oversee the adequacy o l olher aspects ol arlimal care and use.

2 I

- I,

I I

CERTIFICATION BY HEADQUARTES RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible htitutional OMicial)

I cerl~ly Ihat the above is ttuc. correct. atd complete (7 U.S.C. Secllon 21431

1

REPORT OF ANIMALS USED BY OR A


Welfare Re~ula~ions

------------------. 12. &/OR 13. Other

(bs t by species) Miniature Horses

- .. -

SIGNATURE OF CEO. OR INSTITUTIONAL OFFIClAL 1 NAME & T m E OF C.E.O. OR JNSTlNTlOI4AL OFFICIAL flypa w PrmU I =IGNED I


UNDER CONTROL OF RESEARCH FACILITY (Attach adiditionel sheets il necessary or use this lorn).)

8. Number ot animals beicig bred, condi~iorted, or heid tor use tn teaching, IeSring, experimenls,

' research, or surgery but no1 yet used lor such purposes. .

0 -

C Number ol animals uoon which leaching, research, experimenls~ Or

m i s were conducted involving no pain, dstrcss, 0, use 01 pain. reiieving drugs.

3

PART I - WEAEMARTERS

f ) / i C / d

I

D. Number animats upn which uparmenls. ierching, research. sulyery, w lesls were conducted involving accompanying p i n or distress to the a~timals and tor which spproyr,ala alieslhelic, a,lalyesic, or

drugs were UM,

0

I

I

E.. Number of animals upon which leaching, expermenls, research, surgery or tests were conducted involving accornpanytng pain or distress lo the animals and tur which !he use of approprble aneslhelic, analgesic, or lranquillztng drugs would have adversely atlecred Ihe procadureo, results, or inlerprelalion of f he teaching, research. exwrimenls, sur~ery. or lests. (An expianation of the mce<lures producing pain or distress in these animals end the reasons such drugs were not used must be attuched to this reportl.

0

F

TOTAL NO, OF A N ~ M A ~ ~

(colt. c + , . 0 + €1

3

Th~s reDort 1s required by law (7 USC 2143). Failure to repart according to the reoulations can result In an order ro cease and desist and lo be subtec: to nenaltiis as ~rovided for In Sectlor, 21!

See attached form for addittonal information.

I. CERTIFICATE NUMBER: 43-R-0054 I FORM APPROVED OM0 NO. 05760C36


Nestie R 8. D Center, Inc Friskies Ptc 39 16 Pettis Rd St Joseph, MO 64503

ANNUAL REPORT OF RESEARCH FAClLlN ( TYPE OR PRINT )

Telephone: (81 6) -387-4100

I

3. REPORTING FACJUTY ( LSI all locatrons mere anrmals were hwsea or used In actual research, teshng , or expenmentation. or held for these purposes. Attach additional sheels if necessary ) 1 - - -

FAClLlN LOCATIONS ( Shes - See Atacned Lrstmg

- -- - -- . - - - - - - - -

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY 4 Attach additional sheets If necessarv or use APHIS Form 7023A 1 I

C. Number of animals UDMI

which teaching, reseam. experiments, or

0. Number of antmal upon 1 wh~ch experiments.

teaehmg, research,

, conducted ~nvdvlng acvnnpanying p m or distress to the annals an for whrch appropriate anesthetc, analgesic, or

. tranquilrung drugs were used.

- --

E. Number of animals upon which teaching. experiments, F. research, wqety or tests were conducted involving i

: acmmpanying pain w distress to the animals end for wt

drugs would have adversely affected the procedures. raa I or interprataiion of the teaching, research. experirnerrts, I surggr, or tests. ( An explanatii of the procedures . ( COLUMNS

i

A. i 6. Number of animal being bred, mnditioned, or

Animals Cwsred held for use in By The Animal , tetiching, testing,

Wetfare Regulations i experiments. research, or surgery but no! yt

purposes.

tests were conducted involving no pain, distress. or use O' pain-relieving d f ~ g ~ .

4. Dogs i

I

5. Cats I

6. Guinea Pigs I I

10. Sheep

11. Pigs -t- 12. Other Farm Animals ! I -------. 13. Mher Animals '-1 I ASSURANCE STATEMENTS

1 ) Professionalry acceptable stand8rds governing the care; treatment, and use of animals. induding appropriate u!ie cf anestetrc. analgesic, and ranquillzing drugs, prior tc, Ouring. and fdlowing actual rese; teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principal i n ~ e s l i g a t ~ has considered alternatives to painful procedures.

3) Tnis facility is adhering to the standards and regulatrons under the Acf, and it has requrred that exceptians to the standards and regulations be spedfied and expralned by the principal investigator and apr Institutional Animal Care an$ Use Committee (IACUC). A summary of all such exceptions is attached to this annual mpoR In addition to identrfylng the IACUCappmve~ exceptions, this summary in bnei explanabon of me exceptrons. as wel! as tne species anb number of animals afiectsd.

4) The attending veterinarian for this research fadlity has appropriate suthority to ensure !he provision of adequate veterinary care and to overree the adequacy d other aspeds of animal care anb use.

CERTlFiCATfON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Exewtive Mficer or Legally Responsible Institutional Wrcial )

A

DATE SIGNED

This reDort is required by law (7 USC 2143). Faildre to repor! amrdinl; to the regulations can rcr;di in a3 order to cease and deslst end to be subp! to penaltres as provided for in Seclior! 71!


-


I

3. REPORTING FACILITY ( List all locations where animals were houseC or used in actual research. testing

Sse attached form for additional infomatron.

Interagency Report Ccntrol N3.:


CUSTOMER NUMBER: 14 1 8

FORM APPROVED OM0 NO. 057S-0036

Heartland Health System 5325 Faraon St St Joseph, MO 64506

Telephone: (81 6) -271 -6000

or experimentation. or held for these purposes. Attach additional sheets if necessary ) I i LOCATIONS ( Sites ) - See Atached Listing

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY Attach additional sheets if necesganr or use APHIS Form 7023A I I

Animafs Covered By The Animal I Welfare Regulations I

6. Number of animal being bred. conditioned, or held for use in teaching, testing, experiments. research, or surgery but not yr used for such purposes.

-.- 4. Dogs

C. Numberof animals upon whih teaching. research, experiments. or tests were conducted involving no pain. distress. or use o peln-relieving drugs.

. . . . . . . . . . . . . . . . . ---

: D. Number of animals upon which experiments. teaching, research,

! surgery. or tests were mducted involving accompanying pain or distress to the animals an for which appropriate anesthetic, analgesic. or Uanquiliung drugs w m

E. Number of animals upon which teaching. experiments, f. I resear*. surgery or tests were conducted indvinp I accompanying pain or dislress to the animals and for wt the use of appropriate anesthetic. analgesic. or tranqoiiiz

NUMBER

or interpretation of the teaching, resserch, experiments. surgery, or tests. I An explanation of the procedures

I ; drugs would have adversely affected the pmcedures, res , OF

( COLUMNS 1 prcducing pain or distress in these animak and the reax C + D + E ) wch drugs were not used must be attached to this repor

5. Cats .. ----...--. .................

6. Guinea Pigs ... - , . . .

7. Hamsters I - ..... ...............

8. Rabbits ' ' -f ..... --- ......... ............... - . --..

9. #.(on-human Primates i

I 10. Sheep I i 11. Pigs

12. Other Farm Animals i ......... ------.. ...{ ..---

13. Other Animals --.

i .. . . . . . . . . . . . . . ........................ .

I I I ,

ASSURANCE STATEMENTS I 1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic. analgesic, and tranquiiizing drugs, prior to, during. and following actual r€Si

teaching. testing, surgery, or experimentation were followed by this research facility.

2) €am principal investigator has considered atternetives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by ttre principal investigator and ap$ Institutional Animal Care and Use Committee (IACUC). A summary of aH such exceptions is attached to this annual report. In addition to identifymg the IACUC-approved exceptions, mis wmmary in, brief explanation of the exceptions, as well as me species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veierinary a r e and to oversee the adequacy of other aspects of animal care and we.


This repon is required'by raw (7 USC 2145). Failure tc repor! hceo:dmg to the rqulations can resd: m an oraer to cease a i d desist and lo be subject ro penaltles as prov~deo for in SeCt~on 21!


bee anameo tom ror additiona! information.

1. CERTIFICATE NUMBER: 43-R-0 101 I FORM APPROVED OMB NO. 0579-0036

CUSTOMER NUMBER: 1407 I Antigen Laboratories Inc 28-36 S Main St Liberty, MO 64068


Telephone: (816) -781-5222

,. REPORTING FACILITY ; List all locations where ammats were housed or used In actual research. tes , or expenmentatton. w held for these purposes Aka& add~tional sheets tf necessary ) 1

I REPORT OF ANIMALS USED BY OR UNDER :ONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Fonn 70WA \ I A. I 6. Number of animal

I being bred. condi:icncd. a;

Animak Covered held fw use in

Welfare Regulations experiments, research, or surgery but not yc

I purposes.

C. Number of animak upon which teeming. research. experiments. or tests were conducted invoiwng no pain, dislress, or use o pain-relieving drugs.

D. Number of animals upon , which experiments.

teaching, research. surgery, or tests were / ~0ndu~ted inwlving

I accompanying pain w distress to the mimais an fw which appropriate

! anesthetic. analgesic, or tranquilizing drugs were

. -- - . , - - -- - . . - . . I

/ E. M b a of animals upon which teaching, experiments. ! F. msearth, surger). or lest3 ;vex? xnduded involving '

i accompanying pain or distress to the animals and for WP

w interpretation of the teaching, research. experiments,

-- - -

I 6. Guinea Pigs 0 . . . . . . . . . . . . . . . . . . . . . . . . . 1

9. Non-human Primates I 10. Sheep I

12. Other Farm Animals 1 I

13. Other Animals


1 ) RofesSi~nally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic. and tranquilizing drugs, prior to, during, and following actual rese leaching. testing, surgery, or experimeniation were folloiwd by this research facility.

2) Each principal investigator has considered alternatives to painfui procedures.

3) This facility is adhering ta the standards and regulations under the Act. and it has required that exceptions to the standards and regulations be specified and explained by the principar investigator and apF lnstilutional Animal Cam and Use Committee (IACUC). A summary of all such exccptibns is attached to this annual report. In addition to Identifying the IACUC-approved exceptibm, this summary in. brief explanation of the excepbons, as well as the species ana number of animals affected.

4) The attending veterinarian for this research facili!y has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible institutional Offiaal )

I r l ls r e p o n IS r e q u l l a u uy law ( I u 3 ~ L I ra ) . r a t l u r e IU IIVIJII ~GGUIUI~IL) IU u l t i I ~ Y U I ~ I I U I I ~ G ~ I I

resul: in an order to cease and desist and to be sub~ect to Denalties as ~rovided for in Sect~on 21: --- -..--.,-- .-.... .-. .... ,ou,T,,, ""...a ". ..".. additional information. I

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE OM0 NO. 0579-0036 I 1. CERTIFICATE NUMBER: 43-R-0 102


N W Missouri State University 800 University Dr Maryville, MO 64468


I Telephone: f83+-562-M5 660-562- 1388

. L. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or expenmentation, or held for these purposes. Attach additional sheets if necessary ) I


I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 70234 1 I B. Number of animal

being bred. conditioned, or held for use in teaching, testing, experiments, research, or surgery but not ye used for such purposes.

1 C. Number of animals upon which teaching, research, experiments, or tests were conducted involving no pain, distress, or use o pain-relieving drugs.

0

Number of animals upon which experiments. teaching, research. surgery. or tests were conducted involving accompanying pain or distress to the animals an for which appropriate anesthetic, analgesic, or tranquilizing d ~ g s were used.

E. Number of animals upon whlch teaching, experiments. research, surgery or tests were conducted involving accompanying pain w distress to the animals and for wF the use of appropriate anesthetic. analgesic, or tranquiliz drugs would have adversely affected the procedures, res or interpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures produang pain or distress m these animals and the reasc such drugs were not used must be attached to this repon

TOTAL NUMBER GF ANIMALS


Welfare Regulations ( COLUMNS C + D + E )

4. Dogs

5. Cats I I 0 I 0 6. Guinea Pigs - - -- - -. . - . -. 7. Hamsters

I

8. Rabbits I I 0 1 l 3 9. Non-human Primates 1

-.- -.-.- i 0 0 I

.--- ---- 10. Sheep -- n --- 11. Pigs I 0 0 0 0 -I--

0 0 --I- 0 0 I 0 ---


13. Other Animals I 0

I ASSURANCE STATEMENTS 1 1) Professionally acceptable standards governing the care, treatment, and use of animals, indudrng appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual rese.

teaching, testing, surgery, or experimentatin were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act. and It has required that exceptions to the standards and regulations be specified and explained by the principal investigator and app Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifyng the IACUC-approved exceptions, this summary in, bnef explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and lo oversee the adequacy of other aspects of animal care and use.


DATE SIGNED

F

A

t nrs repqrt IS requwee by law j l USC; 2143). Failure to report accordmg t~ the regulations can resuil in an order to cease and desrst and to be subject to mnalties as provided for in Sect~on 21'


ANNUAL REPORT OF RESEARCH FAClLlTY ( TYPE OR PRINT )

See attached form tor additional informat~on.

No.:

1. CERTIFICATE NUMBER: 43-R-0 104



Sinclair Research Center 5701 S Sinclair Rd Columbia, MO 65203

Telephone: (573) -446-6464

rn

3. REPORTfNG FACILITY i L i all localions where animals were housed or used in actual research, testing , w experimentation, or held for these purposes. Attach additional sheets if necessary ) 1

F A C l L l N LOCATIONS ( a e s ) - See h c h e d Listing

I REPORT OF ANlMALS USED BY OR UNDER CON7ROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I


I Welfare Regulations j

. . . . .

4. Dogs .+

- 5. Cats I

-. . . .

6. Guinea Pigs

Number of animal being bred, conditioned, or held for use in teach~ng, testing. experiments, research. or surgery but not yc used lor such pum=.

Number of animals upon which teaching, research, experiments, w tests were conducted involving no pain, distress, or use o pam-relieving drugs.

I ' D. Number of animals upon which experiments, teaching. research, 1 SUrgCJfy, Or t€?Stf W @ n

conducted involving accompanying pain ar

/ Uiiress to the animals an I for which appropriate ! anesthet~c, analgesic, or

tranquilizing drugs were I used.

E. Number of animals upon which teaching, experiments, F. research, surgery or tests were conducted inwlvlng I accompmyir~ pain or distress to the animats and for wP I me use of appropriate anesthetic, analgesic, or tranquilir !

'OTAL NUMBER

drugs would have adversely affected the procedures. res OF

or interpretation of the leaching. research, experiments. surgery, or tests. ( An explanation of the procedures 1 ( COLUMNS I producing pain or distress m these animals and the rearc C + D + E ) such drugs were not used must be attached to this repor.

- -. . . . - ... .-.... .... . . . 7- - .-- - .- . .I. - 8. Rabbits 1 I 1

I . . . . - . .I --.- .. I... - --I.. - -. . . ...-- . .

9. Non-human Primates :

I I . Pigs e-

. .- . . .- . . . ... - - , .- -- - - - 12. Other farm Animals

. -- - ........ I

. - - - - - I ........ A. ... -

i .. ..... . - - - -. - -- ___I. . - . - - - . - - - - .-- --

I I

13. Other Animals I ! . . . . . . . . -- . .... - . - - ...... 1 - -- - - -

I -. . -- - , --- -I-- . A_ . -- --- . ..- A - -

- "-

...

. . . . . . . ... . . . . . . . . -. -- --- .- -. &-. - --

I ASSURANCE STATEMENTS I

1) Professionally acceptable standards governing the care, treatment, and use of animals. induding appropriate use of anestetic, analgesic, and tranquilizrng drugs, prior to. during. an6 following actual rese; reaching, testing. surgery. w experimentation were foliowed by this research fadljr.


3) Thts facility is adhering to the standards and regulations under the Ad, and it has required thai exceptions to the standards and regulations be specified an3 explained by the principa! investigator and apt Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report In addition to identifying the IACUC-approved excepbons, this summary in brief explanation of the exceptions, as well as the species and number of animals affectea.

41 Tine atlending veterinarian for ttr~s research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects o: animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Offcer or Legally Responsible Institutional Official )

SIGNA 1 DATE SIGNED I

( AUG 91 )

This mpo-, is woui:ed by law (7 USC 2143). Failure to repor. according to the regirlatiorrs can result in an order to cease and desist and to be subject to pena!ties as provided for n Section 21:



I. REPORTING FACILITY ( List all locations where an~mals were housed or used in actual research. testing,

see ar:acneo roml ror a~ditlonal information.

I 1. CERTlFicAlE NUMBER: 43-R-0 105 FORM APPROVED I OMB NO. 0579-0036

CUSTOMER NUMBER: 1591 I Missouri Western State College 4525 Downs Dr St Joseph, MO 64507

Telephone: (816) -271 -4234

or expenmentatron, or neld for these purposes. Attach additional sheets if necessary j

FACILITY LOCATIONS ( 9tes ) - See Atached Listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY t Attach additional sheets if necessarv or use APHIS Form 7023A \ 1 A. B. Number of animal

being bred. conditioned. or

Animals Covered I had for use in By The Animal j teaching, testing,

Weltare Regulations experiments, research, or surgery but not yr used for such purposes.

. I r

4. Dogs ,3 a- , I . .

, . .----

5. Cats 0 -A

6. Guinea Pigs .;)'

. - -- 7. Hamsters ; ,/XY=

n. Rabbits ..........


10. Sheep I ..CM 1 1. Pigs

12. Other Farm Animals j .. -- : #.. . I 7 .

13. Other Animals

C. Number of animals upon which teaching, research. experiments. or tests were conducted involving no pain, distress, or use u pain-relieving drugs.

D. Number of animals upon which experiments, teaching, research, surgery, or tests wem conducted involving

: accompanying paln or

i dtstress to the anbmals an i for which appropriate

anesthetic, analgesic, or : Cranpuiluing drugs were , used. ,C_._.. ........

Number of animals upon which teaching. experiments. I F. research, surgery w tests were conduned involving accompanying pain or distress to the animals and for WP

TOTAL the use of appropriate anasthetic, analgesic. or tranquiliz drugs would have adversely affected the procedures. res OF *'lMALS

or interpretation of the teaching. research, experiments,

such drugs were not used must be attached to this repon

: surgery. or tests. ( An explanation d the procedures i ( COLUMNS producing pain or distress in these animals and the reas j C + D + E )

ASSURANCE STATEMENTS 1 1 ) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic. and tranquilizing drugs. prior tc, during. and fdlwving actual rese.

teaching. tesbng, surgery. or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful pmceaures.

3) Tiistacility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal invesrigator and apt Ins;itutional Animal Care and Use Committee (IACUC). A summay of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this Summary in brief explanation of the exceptions. as well as the species and number of animals affected.

4) fhe attending velerinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ficer or Legally Responsible Institutional Official )

ATE SIGNED

This repart is required by b w (7 USC 2143). Fa~lirre to repon according to the reguratrons can result in an ordw to cease and dests! anc to be subrect to ~enalties as oroviaed fcr in Section 21 L

See alached ton; tor addit~onal i ifomlat~x,.

ln~erapendy Repal Control No.:

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH 1NSPECTION SERVICE


1. CERTIFICATE NUMBER: 43-R-0107 I FORM APPROVED OM8 NO. 0579-0036

CUSTOMER NUMBER: 1 595

Linco Research Inc 14 Research Park Dr St Charles, MO 63304

Telephone: (660) -44 1-8400

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or expenmentation, or held for these purposes. Atta& additmal sheets if necessary )

FAC l l lN LOCATIONS ( Sites ) - See Atached Listing

E. Number of animals upon which teaching. experiments, research. surgery or tests were conducted involving accompanying pair. or distress to the animals and for wP the use of spprovriate anesthetic, analgesic. or mnguir i drugs woJd have adversely affected the procedures, res or intwpretation of the teaching. research. experiments. surgery. w tests. ( An explanation of the procedures i producing pain mdlsIress in these mirnab and the reas C + D + E ) I such drugs were nM used must be allached lo this ropol. I

I

C. Number of animals upan which teaching. research, experiments! or tests were conducted involving no pain, distress. or use u pain-relieving drugs. - ............

I

( D. Number of animals upon which experiments, I teaching. research. surgery, or tests were conducted invdving accompanying win or distress to the animals an for which appropriate

! anesthetic, anelgesic, or tranquilizing drugs were used.

2) Each principal investigator has considered alternatives to painful pmAXU€?s.

REPORT OF ANIMALS US ED BY OR UNDER CONTROL OF RESWRCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 i A. / B. Number of animal

, being bred. conditioned. or

Animals Covered . held for use in By The Animal

I teaching, testing,

Welfare Regutatians experiments. research. or

: surgery but not yc ' used for such

a purposes.

-- --. 4. Dogs

... . - . . . . 5. Cats

3) This facility is adhering to the standards and regulatims under the Act. and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and apr Instautiona! An~rnal Care and Use Committee (IACUC). A summary of all such exceplions is attached to this annual repoh In addition to identifying the IACUC-approved exceptions, this summary in brief explanation of the exceptions, as well as the species and number of animals affected.

- .- 6. Guinea Pigs

4) The atlendmg veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

-- -.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible institutional Offrcial )

SIG I DATE SIGNED

. . . . . . -- . .- - . . . . - . . . . . . . . . ti 7. Hamsters ......-. -.- . . . . . . . .- ..

8. Rabbits - - - - - . . i

--T "- 9. Non-hurnan Primates 1 --.. . .-

10. Sheep --.. .

11. Pigs . - .. .- ... . . . . .. I - -

1 2. Other Farm Animals !

-. .

1-- -. . 13. Other Animals -- . -. -

-- ....... - .. - . - . - .

- ---.- ..... _.____.__ i .

_


1) ProfeS~ionally acceptable standards governing the care. treatment. and use of animals. including appropriate w e of anestetl:, analgesic. and tranquilizing drugs, prior to, during, and Mlowing actual re% teaching, testing, surgery. or experimentalion were followed by this research facility.

. :ills reputt waqulleu uy law ( I U ~ C I L I - ~ j . rewte tu I~JJUII OLWIU~IIY IU trle ~ c y u atlull;, ~ O I I

result In an o;der to cease and destst and to be subieft to Denaltes as orov~ded lo: in Section ?if --- -..--..-- .- ... .-. addittonal information.



A B C Laboratories Inc. 7200 E Abc Ln Columbia, MO 65202

I Telephone: (573) -474-8579

1. CERTIFICATE NUMBER: 4343-0 108


I 3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testtng. or experimentation, or held for these purposes. Attach additional sheets if necessary )


1 REPORT OF ANIMALS USED BY OR UNDER

A. B. Number of animal being bred. conditioned. or

Animals Covered held for use in By The Animal teaching, testing,

Welfare Regulations experiments, research, or surgery but not ye used for such purposes.


:ONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 i C. Numberof

animals upon which teaching. research, expenments, or tests were conducted involving no pain. distress, or use o pain-relieving drugs.

-- - - - - - -- .

Number of animals upon E. which expenments. teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals an for which appropriate anesthetic, analgesic. or tranquilizing drugs were used. I

Number of animals upon whfch teaching, experiments, research. surgery or tests were conducted involving accompanying pain or distress to the animals and for wk the use of appropriate anesthetic, analgesic, or tranquiliz drugs would have adversely affected the procedures, res or interpretation of the teaching, research. experiments, surgery, or tests. ( An explanation of the procedures producing pain or diiress in these animals and the reasc such drugs were not used must be attached lo this repon

4. Dogs - --.--*

5. Cats

6. Guinea Pigs

7. Hamsters -.--

8. Rabbits


10. Sheep - .----- -- 11. Pigs - ---- 12. Other Farm Animals 1 - I

13. Other Animals I - I

F.



I w


1) Professionally acceptable standards governing the care. treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual rese~ teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each princ~pal investigator has cons~dered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and apF Institutional Animal Care end Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions. this summary in0 brief explanation of the exceptions, as well as the species and number of animals effected.


CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Offtax or Legally Responsible Institutional Official )

DATE SIGNED

L L # t / o ~ APHIS 88), which is obsolete.)

I 'tus1ur11ef IV allu alke nuuless.

ID: 1596

7200 E Abc Lane Columbia, MO 65202 County: Boone

Telephone (573)474-8579

Attachment A

3. Additional locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes.

Non-Human Primate HousinglTesting Facility University of Missouri-Columbia Laboratory Animal Center Columbia, MO 6521 1

CattlelPigs Housing Testing Facility University of Missouri-Columbia Animal Science Research Center Columbia, MO 6521 1

-

This report is required by law (7 USC 2543). Failure to report according to the regulations can result in an order to cease and desist and to be subject to penalties as provided for in Section 21t




,. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, tes

1. CERTIFICATE NUMBER: 43-R-0110 I FORM APPROVED OMB NO. 0579-0036


Excel Bio Products Inc P 0 Box 104 Washburn, MO 65772

Telephone: (41 7) -826-5981

1, or experimentation, or held for these purposes. Attach additional sheets if necessary ) I


4. Dogs

5. Cats I I 6. Guinea Pigs I

I

7. Hamsters I

8. Rabbits


10. Sheep

12. Other Farm Animals I 11. Pigs

13. Other Animals I I

I


C. Number of animals upon which teaching, research, experiments, or tests were conducted involving no pain, distress, or use 0 pain-relieving drugs.

Number of animals upon which experiments, teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals an for which appropriate anesthetic, analgesic, or tranquilizing drugs were used.

E. Number of animals upon which teaching, experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for wh the use of appropriate anesthetic, analgesic, or tranquiliz drugs would have adversely affected the procedures, res or interpretation of the teaching, research, experiments, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasc such drugs were not used must be attached to this repod

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets if necessarv or use APHIS Form 7023A 1 I



I A.


Welfare Regulations

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual rese; teaching, testing, surgery, or experimentation were followed by this research facility.

B. Number of animal being bred, conditioned, or held for use in teaching, testing, experiments, research, or surgery but not y~ used for such purposes.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and apF Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary in1 brief explanation of the exceptions, as well as the species and number of animals affected.


CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible lnstitutional Official )

APHIS FORM 7023 (Replaces VS FORM 18-23 (OCT 88), which 1s obsolete.) (AUG 91 )

DATE SIGNED


l 'hs report is required by law (7 USC 2143!. Failure to repon according to the regulations can 5ee anacneo rorm lor Interagency Kepm : y O / N t : ' i, resul: In an order to cease and desis! and to be subject to penalties 8s provided for in Section 21! additional information. J'

Lincoln University Po Box 29 Room 306 A, foster Hall Jefferson City, MO 65102

I Telephone: (573) -681 -5074 I


I

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTlON SERVlCE

1 I 3. REPORTING FACIUTY ( bst all locations where an~rnals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary ) 1

1. CERTlf KATE NUMBER: 4343-0 1 1 1 CUSTOMER NUMBER: 1677

FACILITY LOCATIONS ( Sies j - See Atached hstivg

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I A. 6. Number of animai

being bred,

i conditioned, or

Animals Covered held for use in By The Animal teaching. testing,

Welfare Regulations experiments. I resear&. or : surgery but not ye

used fw such i PurP-.

, ........ ........... ,

7. Hamsters . . . . . . . . . . . . . . . . . . . . . . . . . . .

8. Rabbi

.. - 12. Other Farm Animals ,

I I I -. . - ........ - I

13. Other Animals --. .........................................

I ,

i I i

C. Number of animals upon which teaching, research, experiments, or tests were conducted involving no pain. distress. or use a pain-relieving drugs.

1 D. Number of animals upon which experiments, teaching, research.

. surgery. or tests were

I conducted involving accompanyng pain or distress to the animals an for which appropriate

I anesthetic, analgesic, or tranquilizing drugs were

i used.

i ! E. Number of animals upon whch teaching, experiments, F.

researcn, surgery or tests were conducted inmlvmg accompanying pain or d~stress to the animals and for WP I

; the use of appropriate anesthetic, analgesic. or tranquilit I NUMBER

drugs would have adversely affected the procedures. res . OF AN'MALS

of interpretation of the teaching. research, experiments, . surgery, or tests. ( An wanat ion of the procedures

i producing pain or distress In these animals and the reasc such drugs were not used must be attached to this repw

! !

I i ASSURANCE STATEMENTS

I

1 j Professonally acceptable Standards governing the care, treatment. and use of animals, induding appropriate use of anestetic, analgesic. end tranquilizing drugs, priw to? during, and following actual resa teaching. testing. surgery, or experimentation were followed by this research facility.

~ 2) Each prinupal investigator has mnsidered alternatives to painful pmcedures.

3) This facliity is adhermg to the standards and regulations under the Act, and it has required that exceptibns to the standards and regulations be specified and explained by the principal investigator and apt institutional Animal Care and Use Camm~ttae (IACUC). A summary of alt such exceptions is attached to this annual report In addition to identifymg the 1ACUC-approved exceptions. this summary in; brief explanation o l the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research f ac i l i has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

CERTtFICATlON BY HEADQUARTERS RESmRCH FACILIN OFFICIAL ( Chief Executwe Officer or Legally Responsible Institutional Mficial )

I DATE SIGNED

I I X I I C ~ A L 15 I ~ U I I G U w y law \ t uab r I-JI. I awn= LU I G ~ U I I PU.UIUIIIY LU k t ~ c IcyuIattusIa La11

result In 'jn order to cease and des~sl and to be subject to penalt~es as provided for in Section 21:


1. CERTIFICATE NUMBER: 4343-0 1 12 I FORM APPROVED OM8 NO. 0579-0036


Southeast Missouri State One University Plaza Cape Girardeau, MO 63701


Telephone: (573) -651 -21 70

1. REPORTING FACILITY ( Llst alf locat~ons where animals were housed or used In actual research, testing, or experimentation or held for these purposes. Attach addlbonal sheets if necessary ) I


1 REPORT OF ANIMALS USED BY OR UNDER ONTROL OF RESEARCH FACILITY f Attach additional sheets if necessarv or use APHIS Form 7023A 1 I C. Number of

animak upon which teaching, research, experiments. r?r

tests were conducted involving no pain, distress, or use o. pain-relieving drugs.

D. Number of animals upon whch experiments. teaching, research, surgery, or tests were sonduZd ixclvlnp accompanying pain or distress to the antmals an for which appropriate anesthetic, analgesic, or tranquilizing drugs were wed.

1 E. Number of animals upon which teaching. experiments. i F. B. Number of animal being bred, conditioned, or held for use in teachin5 tes!in~ experiments, research, or surgery but not ye used for such

research, surgery or tests were conducted invdving accompanying pain or distress to the animals and for w t the use of appropriate anesthetic, analgesic. or tranquiliz ,

NUMBER

& u p would Lave a-y affened the pr-ures, res ; OF

or interpretation of the teaching, research, experiments, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasc such drugs were not used must be anached to this repon

f


Welfare Regulations

- 7. Hamsters 1-

I

s. Rabbits - 9. Non-human Primates

10. Sheep I I 1 1. Pigs


13. Other Animals

---.- .--..-


1 ) Professionally acceptable standards governing the care. treatment, and use of animals, including appropriate use of anestetic, analgesic. and tranquilizing drugs, prior to, during, and following actual rese; teaching, testing, surgery, or experimentation were followed by this research facility.

2) Each principat investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and apF Lnstituttonal Anlmal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUCapproved exceptions, this summary in brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the prowsion of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.


)

ID: 1757

One Universitiy Plaza Telephone Cape Girardeau, MO 63701 4799 (573)651-2170

County: Cape Girardeau

--

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PIAM' HEALTH INSPECTION SERVICE

FORMAPPROVED OMB NO. 0579436

,

e

Central Biomedia Inc 9900 Pflumm Rd Unit 61 Lenexa, KS 662 1 5

I

Central Bfomedia, Inc. 0425 Vast "V" Ewy, Irvin, MO 64759FAawLmnm{~)

- I

L

ANNUAL REPORT OF RESEARCH FACILITY ( WPE OR PRINT )

Telephone: (913) -5414090

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILTTY ( Attech additknd sheets if r#caum or use APHIS Form 7023A 1 1 I C. hlunborof

animals upon which tscrchng. -. .x#rimsnEE. w tosawas mndudad hw~ng no prin, d ~ , O r ~ U pairwding dNgs.

D. Number d inhnals upon w h i i ~~. ~ e h i n g . ~ , surgofy.ormt8rvsre

in-9 "O"pa"vhp win distress to the snimls an f# whii a~~ ammetk ambdc, or ~ i d ~ w a e used.

Number d nknIQ upon which treching, expsrimarts, rrsssrch,~sry~~waeawlUudsdimrdvlnp accompanying pain or dbdmss to the animal6 and for wh rn used approghtr m m t h e ~ analgas&. or tnnquaiz drup &d hove &- dWad Ulcr pmaduros, rcs or MrpnWion dmeteeehing, msmrch, emrirnntJ, surgery. a tasis. ( An mphnatbn of the procrdum pdudng prin or dktmm in these animals and mast ~ d f u g s w e f e n o t u # d m w l b e . t t P c h e d t o t h i r ~



I

8. G- P&s

7. Hamstsn

8. Rabbits


lo. sheep

11. Pigs

12. Other Fann Animals

I

A S S U R A W # S T A ~ S I

1) V m H y &We sbnbrds goMminq tha m, m t md urs of anlmrls. indudha awoprich use danmidc. mmlgwk md rnnquZlhin~ dnrgs, prior to, during, and Wowing acwl mm teaching, testing. s q ~ a r y , or #prrirnonmm u m fdkrusd by this rcasmh fadlily.

3) This f8dYty is ad- to ltw smmiards end regulrtions under the kt, a d it h9 nqubld lh6t sxGepbjw to the stadrnls a d mgt.Artbns be s p d f k d end e x p h h d by the prindpd invesl[getor and rpc krJMulional Ananal Care md Uoa Commiltw IUCVC). A ru#nm d all such naotbnr L .tOclwd to thb annual nwrt In ddition to Mantifvins the 1ACUC-a- excdbm. Chis rummsrv in1 - - b r i e d ~ m a t r a n d ~ ~ . s ~ . r t h s s p . d . s n d n u & d m i n r & & .

4) The attanding mmlnarian tar this rosearch M i t y hes appropmto wtnority to enam the prwision of adequate velwinary cam ad lo ovemw the adquay of omif .specb d Mim J a m md use.

CEWnFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible InstiMional Olficial )

A L J I DATE SlGNEO

* - *

, ID:1790

0425 West Y" Hwy Irwin, MO 64759 County: Barton ,

Telephone (913)5414090

LINlTEC STATES DEPARTMENT OF AGRlCULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE CR PRINT )

<. CERTIFICATE NUMBEFZ: 43-R-0 1 1 5

CUSTOMER NUMBER: 1603C

3. REPORTING FACILITY ( L:sr ail 13catior.s met; animals were P.cu=$ or gsed ir, axusl ;eses:ih. ;&sting, or exoerimenta:ion or held far t%se su'poses. Attach abditicna! sneets i i necessari j I

Vstterott Edticatimal Center Vatterott College 10463 internationai Plaza Drive St Ann, MU 63074

Telephone: (314) -890-8484

A. 6. Number of animal ; being bred. i cmditioned, or

Animals Covered i heid for ;rse In By The Animal i ;eacning, testing.

Welfare Regulations experiments. : research, or i surgerj Sut not YE

; usec! for such I purposes.

.- - -. ---------.---- &. Dogs

..-.......... --- .................. -..-- -- ... 6. Guinea Pigs

-.-------

7. Hamsters I

-- --7.

j

? 8 Rabbits


10. Sheep 1 --- i

11. Pigs !

. . --. ..-.--.. ..-... .-- ............................. 12. Other Farm Animals

,--c...--..-- --.--- .. ... --- ----.,

13. Other Animais


C. Nurn~erof animals upon which teaching. research. experiments, or tests were conducted involving no pain. dist:ess, or use u' pain-relieving drugs.

D. Number of animais upon whim experiments. i leaching. research,

I surgery, w tests were i mducted involwng

accompanying pain or distress to the enimafs an / for *Ich appro~riale anesthetic. analgesic. or tranquilizing bugs were Used.

E. Number of animals upon which teaching. experiments. research. surgery or tests were mduc l& Invoking

1 accompanying pair? or d~stfess to tne animals 3nd for wr ;

:as use of appropriate anesthetic, anaigesic. or Sranquilit NL'MBER i drJgs ~Ou ld nave adversely affected the procsdures, res .

OF

1 or intcr~ref i tm of tne teaching. research. experiments. :

i surgery. or rests, i M expranatim of me pmsoarres ( COWMNS pmducinp pain or cWm In these animals and [he RaY ! C + D + E ) such omas were not used mLst be attaWm¶ :o this r e ~ o r i

- -- - - -- - - - - - - - -

1 j. mfessiondly acceptable sandarcs jovernrng the are. treauner.i. and use of animals, including appropriate use cf anestetic, analoesic. and t ranauk~r~g C r q s . prior 13. during, and :dlcwing actuar rese. teaching. testing. surgery, or axperimentation were followed by thrs research facilfiy

21 Eat? principal ir.vest@iOr has ccns~dered altemabves tc painfui procedures.

3: feciii~y if adhefin9 1c :he standards and regurai~ons under the At:. ana it has :s:uired thal exceplions to the standards and re~ulaticis be specRed aaa a ~ 1 a i r . d by Me prlnci~al lnvestigatar and 3FF

Ins:it~tinnal Animal Care and USE. Cornminee (IACUC:. A summary of all such exceptions is attached to this annual report. h adCitlor! rs ideniifyico the IACUC-approved exceptrons. this simmary In brief explanarron cf the excep:ions, as weil as the speces and number of animals affected.

4': T>e anendir.~ vete3nar:ar for tnis researin iacility bas aaprapriate au!no:ity to ensure ?he crovSo: cf adequate veterinary care and r3 oveme :he acequacy cf cther aspects of anmal care an5 use

CERTlFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Oficial )

i AUG 91 j

J

- - - - - - - . - -- - - - - - - - -. - - - -- --- - - .

.

APHIS FORM 7223 1Ge2laces VS FORM 18-23 (OCT 86 1. *With IS oosolete.)

DATE SIGNED

j / b

This report is required by law (7 USC --------- ---------- --- ------ --------------- --- ----- ----------------- ------ ------ ----------- ------ ---- remit in an order to cease and desist and to be^ Subiecf to 0 ~ a l t i t s as provided for in Section 21 50. addilanel information.

Interagency Report Control No 01 80-DOA-AN

I I

2. HEADQUARTERS RESEARCH FAClUrY (Name and A m = , 8.9 regblsrecl wftf7 USDA ANNUAL REPORT OF RESEARCH FACILITY mc~ude zip code)

(TYPE OR PRINT) CELSIS LABORATORY GROUP, ST LOUIS, INC 6200 S LINDBERGH BLVD

. I .

. .

- ---------------------------- I ---- -- -- - - --- - - - - - - - - - - - - - - - - - - - - - - - - --

) 3. REPORTING FACILITY {Lst a11 locations where animals were homed w used in actual research, testing. taedring. or experimtstion, or held for thaw pwpaws. Atractr additional J sheets if necessary.)

FACrLrlY LOCATtONS(sh?aI

SITE1 I

FORM APPROVE0 OM8 NO. 05t8M138


REPORT OF ANIMALS USED BY

?. REGISTRATION NO. CUSTOMER NO. 43-R-2 1518


Wslfare Regulations

{Amch ad- shseM nece 0. Number d a n i d s upon

whtch expariments, teaching. rsseuch, surgery, or tests were m d u c t d invdving accompanying pain or dlstrsss ta the animals and for which appropriate anesthe!ic, analgesic, or tranquilking drups were wed.

M? UNDER CONTROL OF RESEARCH FAC1LI"I say or use APUlS FORM 7023.4 1 E. Numbor of animals upon whrdr teaching,

experiments, research, surgery or mb w e conducted involving aiccavmying pin w distrsM to the animds Md for which the u6e of appwdeta a m Y r e c i c a n a l ~ c , or tranqulling bugs W d have advensly affectsd the procdurs8, mulb, or intarpmbtion of h e teaching. msewch, experiments, sutgary, or Issts. [An exdiwdbn d t h e ~ ~ p e i n f f ~ e 3 8 m ~ animals antf Ule reasom such W s wtm mt rrsod must be eti%ched to thG reprwr)

B. Number of antmalS bang

1 bred, conditioned. or held for use in teach~ng, testing, experiments. research, or surgery but not yet wed for such wrposw.

TOTAL NO, OF ANIMALS

C. Numberof animals upan which teachmg, resaaM. expenmellts. w testa W e condudad involving no gain, distress, w use of pain- relieving d w .

4. Dogs

5. Cats I I

7. Hamsters I I I I I

6. Guinea Pigs I 4

9. Non-Human Primates I

522

8. Rabbits

t 2. Other Farm Animals

I 522

60 I 561

1 I I 1 1 ASSURANCE STATEMENTS

r

1) Messiarlally acceptable standards governing the cam, treatment and use of animals, including appro~riete use of anesthetic, analgasic, and hnquilidng dugs, p r l ~ to, during, and foilowing achrat research, teaching, testing, sorgwy, or axpsrimenlation wera followad by this reuamh facllity.

I

13. Other Animals

2) Each principal investigator has considered almativerr to painful pmeedwas.

2

I

3) This fadlily 19 adharing to the standards end regulations under me Acf and it has required that exceptlone to the standards and mgdatlom be spdfied and explshd by the principal investigator and approved by the Inst i tuW Animel Cam and Use Cornnitlee (IACUC). A runnuy of all tha rr#9tbW b atrchd t0 thb *nMlrl w o r t h addition to identifyrng the IACUGapprwsd exception$, ma SWnfMry induda a bod explanation of the sxceptions, as well as the spsdss m d number d Mim8h snsctd.

I

4) The attending veterinarian for this research facility ha8 appropriate authority to enwre the provision d adequate vetotinary cam and to ownee the adWWCy of athw wpscts of animal can and use.

43

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL {Chief Executive Officer or Legally Responsible Institutional official)

I eerUfy that the above is true, c m t and complete (7 U.S.C. Sectkn 214 ) SIGNATURE O f C.E.O. OR INSTITUTlONAL OFFtCML I NAME & T I N E OF C.E.O. OR INSTINTIONAL OFFICIAL (Typ of PMtj I DATE SIGNED

606

I IIR7R002 I APHIS FORM 7023 {Ropl;r~08 vs FORM 18-23 (ocl M), which ir 0b.o-

(AUG 91 ) PART 1 - HEADQUARTERS

All redactions on this page are pursuant to (b)(6) & (b)(7)(c).

APHIS Form 7023 Column E Explanation

This form is intended as an aid to completing the APHIS Form 7023 Column E explanation. It is not an official form and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.

1. Registration Number: 43-R-0002

Z3. Species (common name) & Number of animals used in this study:

Rabbits (43)

4. Explain the procedure producing pain and/or distress.

Explanations for ?E? Pain Classification - USDNAPHIS year 10f01-9/02

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. (For Federally mandated testing, see Item 6 below)

Explanations for ?E? Pain Classification - USDAlAPHlS year 10101-9102

6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 113.102):

Agency: Explanations for ?E? Pain Classification - CFR: USDA/APHIS year lO/Ol-W02

1. Registration Number: 43-R-0002 / 1518

2/3. Species (common name) 8 Number of animals used in this study:

Rabbits (43)

4. Explain the procedure producing pain and/or distress. ?

Explanations for ?E? Pain Classification - USDNAPHIS year 10101-9/02 During the USDA animal year of October 1,2001 through September 30, 2002,44 rabbits were used in tests causing pain or distress. Twelve rabbits used in Eye Irritation testing received the ?E? pain classification. Six rabbits were used in an Eye Irritation study in which all six rabbits

. exhibited chemosis, redness and opacity after only an hour of exposure. Since the pain relieving medication we had : available has a relatively short effective period, we chose not to use it and instead rinsed out the test sample from the test

eyes (with warm sterile saline) at the one hour time point, instead of the required 24 hour time point. Even though the test material did not remain in the eyes for the required 24 hours, the sample was deemed to be an eye irritant. On a different sample , six rabbits exhibited chemosis and redness within 1 hour of instillation. These reactions lasted 4 days.

: This sample resulted in a Toxicity Category 11 label. Twenty-four rabbits used in Primary Dermal Irritation tests received the ?E? pain classification. Six rabbits had erythema scores of 4 at Day 7 and did not appear to be in pain. These scores returned to zero and t by Day 14. Twelve rabbits, although they did not exhibit signs of pain or distress, received the ?E? pain classification based on the severe erythema and necrosis reactions observed during the test period. Six different rabbits had imtation scores of moderate erythema during their test but also did not appear to be in pain. ?E? pain classification designated on severity of initation scores verses sign of painldiscomfort, to be on the conservative side. Eight rabbits on the Pyrogen test received the ?E? pain classification. Three rabbits were used in pyrogen tests involving a product that resulted in exposed raw skin at the eaf?s injection site. It has also been noted that if the product is not fully

r injected intravenously, and infiltrates into the surrounding tissue of the ear, that necrosis of the injection area may occur. Care is taken to ensure that the needle has proper intravenous placement, that the product does not drip onto the ear and that the ear is properly occfuded following the sample injection. Five rabbits were either found dead or were euthanized

I within a couple of days of completing the Pyrogen test on either the active or placebo of a particular product. (The rabbits which were euthanjzed were done so due to their pale eyes, toss of appetite and lethargy.) The pyrogen tests, USP 24 €1 52 > and 21 CFR 61 0.13 do n--- ------- ---- ---------------------- of pain-relieving drugs ----- --- ------ ------------ --- -------- re with the test. Written by: ------- --------- ------------ ----------- Acknowledged by: ------- --- ------------- --- ---------- Chairman Anne Pickles, Vice President, General Manager Institutional Officer

5. Provide scientific justification why pain andlor distress could not be relieved. State methods or means used to determine Mat pain and/or distress relief would interfere with test results. (For Federally mandated testing, see Item 6 below)

Explanations for ?E? Pain Classification - USDNAPHIS year IOiOl-9lOZ During the USDA animal year of October 1,2001 through September 30,2002, 44 rabbits were used in tests causing pain or distress. Twelve rabbits used in Eye Irritation testing received the ?E? pain classification. Six rabbits were used in an Eye Irritation study in which all six rabbits exhibited chemosis, redness and opacity after only an hour of exposure. Since the pain relieving medication we had available has a relatively short effective period, we chose not to use it and instead rinsed out the test sample from the test eyes (with warm sterile saline) at the one hour time point, instead of the required 24 hour time point Even though the test material did not remain in the eyes for the required 24 hours, the sample was deemed to be an eye irritant. On a different sample , six rabbits exhibited chemosis and redness within 1 hour of instillation. These reactions lasted 4 days. This sample resulted in a Toxicity Category II label. Twenty-four rabbits used in Primary Dermal Initation tests received the ?E? pain classification. Six rabbits had erythema scores of 4 at Day 7 and did not appear to be in pain. These scores returned to zero and 1 by Day 14. Twelve rabbits, although they did not exhibit signs of pain or distress, received the ?E? pain classification based on the severe erythema and necrosis reactions observed during the test period. Six different rabbits had ititation scores of moderate erythema during their test but also did not appear to be in pain. ?E? pain classification designated on severity of irritation scores verses sign of painidiscomfort, to be on the conservative side. Eight rabbits on the Pyrogen test received the ?E? pain classification. Three rabbits were used in pyrogen tests involving a product that resulted in exposed raw skin at the ear?s injection site. it has also been noted that if the product is not fully injected intravenously, and infiltrates into the surrounding tissue of the ear, that necrosis of the injection area may occur. Care is taken to ensure that the needle has proper intravenous placement, that the product does not drip onto the ear and that the ear is properly occluded following the sample injection. Five rabbits were either found dead or were euthanized within a couple of days of completing the Pyrogen test on either the active or placebo of a particular product. (The rabbits which were euthanized were done so due to their paie eyes, loss of appetite and lethargy.) The pyrogen tests, USP 24 < 151 > and 21 CFR 61 0.13 do ----- ------- ---- ----- ------------------- of pain-relieving drugs ----- --- ------ ------------ --- --------- e with the test. Written by: ------- --------- ------------ --------- Acknowledged by: ------- --- ------------- --- ---------- Chairman Anne Pickles, Vice President, General Manager Institutional Officer

What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g,, APHIS, 9 CFR 113.102):

Agency: Explanations for ?E? Pain Classification - CFR: USDAJAPHIS year 10101-9/02; During the USDA animal year of October 1,2001 through September 30,2002,44 rabbits were used in tests causing pain or distress. ; Twelve rabbits used in Eye Irritation testing received the - - - - - - - - t?:.. -ahL:+- ,,,,,A ,,-,A :n o m C . r n


reoness ana opaclry aner only an nour or exposure. m c e the pain relieving medication we had available has a relatively short effective period, we chose not to use it and instead rinsed out the test sample from the test eyes (with warm sterile saline) at the one hour time point, instead of the required 24 hour time point. Even though the test material did not remain in the eyes for the required 24 hours, the sample was deemed to be an eye irritant. On a different sample , six rabbits exhibited chemosis and redness within 1 hour of instillation, These reactions lasted 4 days. This sample resulted in a Toxicity Category 11 label. ; Twenty-four rabbits used in Primary Dermal lrritation tests received the ?E? pain classification. Six rabbits had erythema scores of 4 at Day 7 and did not appear to be in pain. These scores returned to zero and 1 by Day 14. Twelve rabbits, although they did not exhibit signs of pain or distress, received the ?E? pain classification based on the severe erythema and necrosis reactions observed during the test period. Six different rabbits had irritation scores of moderate erythema during their test but also did not appear to be in pain. ?E? pain classification designated on severity of imitation scores verses sign of painfdiscomfort, to be on the conservative side. ; Eight rabbits on the Pyrogen test received the ?E? pain classification. Three rabbits were used in pyrogen tests involving a product that resulted in exposed raw skin at the ear?s injection site. It has also been noted. that if the product is not fully injected intravenously, and infiltrates into the surrounding tissue of the ear, that necrosis of the injection area may occur. Care is taken to ensure that the needle has proper intravenous placement, that the product does not drip onto the ear and that the ear is properly occluded following the sample injection. Five rabbits were either found dead or were euthanized within a couple of days of completing the Pyrogen test on either the active or placebo of a particular product. (The rabbits which were euthanized were done so due to their pale eyes, loss of appetite and lethargy.) The pyrogen tests, USP 24 <I51 > and 21 CFR 610.1 3 do not allow for the administration of pain-relieving drugs due to the-- ------------ --- ----------- ------ the test.; Written by: ------- --------- ------------ Biofogy ; AcknoMedged by: ------- --- ------------- - - -- IACUC Chairman; Anne Pickles, Vice President, General Manager; Institutional Officer

: Approval Status: Approved/Disapproved By: Date:

Disapproved Reason:


(b)(4)

See attached form lor additional information.

This report is required by law (7 USC 2j43). Failure to report according to Iha ngulations can result in an order to cease and desist end to be subject to penalties as prowled fa in Secton 211

UNITED STATES DEPARTMENT Of AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

-

,. CCRTIFICAE W r n 4 3 ~ 4 1 1 4 FORMAPPROVED OM0 NO. 057%0036

CUSTOMERNWJER: 1823

. . ., i < -

Quintiles, Inc. 10245 Hickman Mills Dr Kansas City, MO 64137

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRIM )

Telephone: (81 6) -767-6000

FAClUTY LOCATIONS ( sites ) - S e e m bung

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets if -saw or use APHIS F orrn fQt3A I I Number of animal being bred. conditiclmd. or held for use in Issching, testing. 6xpsnmcurts. re9eSICh, or surgery but not yc used fw such purposes.

TOTAL NUM6ER OF ANIMALS

Animals Cowred By The Animal

Wetfore Reguktiono ( COLUMNS C + D + E )

5. Cats

6. Guinea Pigs

8. Rabbits .- -

9. Non-hurnan Primates

12. Other F a n Animals

3 3. Mher Animals

STATEMENTS

C E R T I F I C A ~ BY HEAWUARTERS fESEARCH FACILITY OfflClAL ( Chief b c u h Olfiir or Legally Resparrsible Institutional Offcial)

'MTES~GNED

p", . ,. j;, L

" & '

APH

Quintiles, Inc., Kansas City, MO Registration No. 43-R-0114

2002 USDA Annual Report Column E Explanations

Species: Rabbit

Number of Animals: 1

Procedure Producing Pain or Distress: A jugular cannulated rabbit struggled during routine blood collection, and died.

Scientific Justification Why Pain or Distress Could Not Be Relieved: Not applicable (study procedure was not anticipated to cause pain and/or distress)

Federal Regulations Requiring the Procedure: Not applicable

Species: Rabbit


Procedure Producing Pain or Distress: Rabbit was found with foot caught in cage floor grid and was euthanized.

Scientific Justifbation Why Pain or Distress Could Not Be Relieved: Not applicable (study procedure was not anticipated to cause pain and/or distress)


Study 8205 (26Apr02)

Species: Dog


Procedure Producing Pain or Distress: Dog was found dead in cage, an unexpected reaction to dosing with compound.



Quintiles, Inc., Kansas City, MO Registration No. 43-R-0114

2002 USDA Annual Report Column E Explanations

Study PK-785

Species: Dog


Procedure Producing Pain or Distress: Dogs had an unexpected reaction to dosing with compound.



Species: Dog





Species: Dog


Procedure Producing Pain or Distress: Dogs had an apparent systemic allergic reaction to vehicle.



Species: Dog





1 3 i - usda-aphis...certificate number: 43-r-0005 customer number: 1487 form approved om0 no....

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