11/10/2013

1

Present yourself – round table

QUASAR Segmenation/PVC

IVIM: Perfusion fraction??

Clinic?

André Ahlgren

Medical Radiation Physics

Lund, Sweden

11/10/2013

2

Combination of DTI and ASL for Brain Tumor studies

Radiology and Tumor Immunology Departments

Radboud University Medical Centre

Nijmegen, The Netherlands

Jennifer Andreotti

• M.sc. in Mathematics

• PhD at the University Psychiatric

Hospital of Bern, Switzerland

• Research interests:

- diffusion weighted imaging

- tractography and HARDI methods

- brain network properties

• Why an ASL course?

…to study the relationship between

the structural network and CBF

11/10/2013

3

Dr Tomoki Arichi• NIHR Clinical Lecturer in the Department

of Perinatal Imaging at King’s College

London

• Visiting researcher in the Human

Robotics Group, Imperial College London

• My research interest is the application of

functional imaging techniques in

newborn infants

• My background is predominately in BOLD

contrast fMRI

• I hope to apply ASL techniques to learn

about perfusion and as a functional

imaging technique to further characterise

early brain development, and the effects

of pathology

BACKGROUND

- MR physics

- MR sequence programming, image reconstruction & data analysis

- Neuroimaging

INTERESTS & CURRENT PROJECTS (quite likely similar to many of us!!)

- MR data acquisition, development of MRI sequences, optimization, validation, basic data

processing, image reconstruction, quality assurance (SNR, stability, artifact detection) …

- Development of high resolution and high CNR protocols for quantitative MRI, including T1,

T2, MT, PD, phase imaging, susceptibility mapping, diffusion and perfusion.

- Application to large-scale longitudinal and cross-sectional studies aiming at characterizing

the human neuroanatomy

- Multiparameter analysis and machine learning, combining MR modalities with different

sensitivities to specific brain structures, to characterize pathologies…

EVELYNE BALTEAU

Cyclotron Research Centre

University of Liège – BELGIUM

e.balteau@ulg.ac.be

11/10/2013

4

Marco Battiston

Graduate student, Bioengineering

Department of Engineering of Information

University of Padova

Main research interest:

�Magnetic Resonance Imaging field � Arterial Spin Labeling

�Bayesian inference of data model

ASL Training School Toulouse,

30th September – 2nd October

Courtney Bishop

Current position(s)

• MR Analyst at Imanova Centre for Imaging Sciences, Hammersmith Hospital,

London, UK (2012 – present)

• Honorary Research Officer in the Centre for Restorative Neurosciences at

Imperial College London, UK (2013)

Previous research experience

• PhD in clinical neurosciences at the FMRIB Centre, University of Oxford, UK

(2007-2012), with focus on hippocampal segmentation methods for dementia

• MChem at the University of Oxford, UK (2003-2007)

Research interests

• Dementia

• Structural and functional MRI, PET

• Analysis techniques for processing both 3D-GRASE FAIR ASL and QUIPPSII

ASL data

• DCE-MRI

Presentation, Date

11/10/2013

5

Ilaria Boscolo Galazzo

31-10-1985, Chioggia (Venice), Italy

I have received my master degree in Biomedical Engineering in 2010 from

University of Padua. I’m currently attending the PhD programme in Neuroscience

at the Department of Neurological and Movement Sciences, University of Verona.

My research activities can be summerised in the following points:

� acquisition and analysis of perfusion MRI data with Arterial Spin Labeling

(ASL), in healthy subjects and several diseases as epilepsy, dementia and

stroke;

� integration of ASL data with the results from other imaging techniques, in

particular FDG-PET, EEG-fMRI, ESI, for quantitative assessment of drug

resistant focal epilepsy;

� application of ASL for functional studies (ASL fMRI) and comparison with

BOLD fMRI.

General Information

• 1st year PhD student

• SPMMRC at University of Nottingham• Main research area is cardiac ASL• Looking at developing a Look-Locker readout technique for

cardiac ASL using a FAIR labelling scheme to estimate cardiac perfusion.

Charlotte Buchanan

11/10/2013

6

Marco Castellaro

PhD Student

Functional and anatomical Imaging research group

University of Padova

Department of Information Engineering

Research Interest:

Magnetic Resonance Imaging Dynamic Susceptibility Contrast

Arterial Spin Labeling

Signal and Image Processing Deconvolution problems

Compressed Sensing

Application to Clinical Multiple Sclerosis

Tumors

Cristoffer Cordes

• Education: M.Sc., Mathematics

Bremen(DE)/Clemson(USA) ´11

• Currently working at: Fraunhofer MEVIS

• Main research interest: MRI Simulation,

particularly utilizing the k-space formalism

• Personal interests: Internet culture, video games,

electronic music, dark humor

11/10/2013

7

Investigating the BOLD Response at 7T

via blood gas modulations

Paula Croal

PhD Student

Sir Peter Mansfield Magnetic Resonance

Centre

The University of Nottingham

Dr Enrico De Vita

Main Research Interests (ASL):

-MT effects of Q2TIPS pulses

-optimisation of signal readout

(3DGRASE vs 2DEPI)

-multi-TI acquisitions

-post-processing methods (e.g.

deblurring)

-optimisation of ASL protocols for

clinical use (product and research

sequences)

Clinical Scientist (MR Physics)

Department of Neuroradiology

National Hospital for Neurology and Neurosurgery

Queen Square, London, UK

e.devita@ucl.ac.uk

11/10/2013

8

Ingrid Digernes

• Master’s degree – Applied physics and mathematics

Norwegian University of Science and Technology

• The Intervention Centre at the Oslo University Hospital

• Main focus: Partial volume effects in ASL.

Markus Fahlström

• Medical Physicist

• MRI

Uppsala University

• Dept. of Radiology

• Neuroradiology group

Main Research Interests

• Perfusion

• Diffusion

• MRI-Safety/Implants

Contact information

Markus.Fahlstrom@radiol.uu.se

11/10/2013

9

Øystein Bech Gadmar

MR physicist

Intervention Centre, Oslo University Hospital

Current interests (2013):

• ASL analysis and implementation

• Pulse programming for Philips scanners

• BOLD fMRI implementations for research and clinic

• Quality Assurance routines for MRI

• MR physics in general

• Computing solutions

Pablo García-Polo, PhD Student

• Laboratory of Neuroimaging at Fundación CIEN-Fundación Reina Sofía in Madrid (Spain)

• Research Centre in Neurological and Neurodegenerative Diseases

Neuroimaging post-processing techniques:

• Hypoperfusion in neurodegenerative diseases (Alzheimer)

• Partial volume correction in pCASL acquisition

• Confounding variables in ASL studies

11/10/2013

10

Stéphanie Giezendanner

• M.sc. in Neuropsychology

• PhD at the University Psychiatric Hospital of Bern, Switzerland

• Research interests:

- Diffusion tensor imaging

- Analysis of white matter (WM) integrity

- TBSS, FSL

- Neuronal correlates of psychiatric symptoms

• Why an ASL course?

… to analyse perfusion in WM

Name: Thorsten Honroth

Institute: Fraunhofer MEVIS / University of Bremen

Tasks: ASL Sequence Development

ASL post-processing and quantification

(Using PASL (FAIR) with 3DGRASE)

11/10/2013

11

Raimo Joensuu

Physicist, Dr.Tech.

Glostrup Hospital, Functional Imaging Unit

Copenhagen, Denmark

Ina Nora Kompan, PhD student (in Matthias Guenther’s group)

Fraunhofer MEVIS, Bremen, Germany

• Administrator of the ASL homepage

www.asl-network.org

• Administrator of the COST Action BM1103 homepage

http://www.aslindementia.org/

• ASL Network Newsletter:

monthly summary and classification of

the latest ASL publications

(succeeding Johanna Kramme)

• Organization of ASL Network social events

(with Johanna Kramme)

• Research topic: Currently DCE-MRI, no ASL ����

• ASL in diploma thesis: Slab positioning in regional ASL

Any suggestions for the homepage or Newsletter?

Don’t hesitate to contact me!

11/10/2013

12

Mervi Könönen mervi.kononen@kuh.fi

►Hospital physicist, over 20 years

► Kuopio university hospital: depts of clinical radiology and neurophysiology, National epilepsy center

►Neuroimaging: MRI (fMRI), navigated transcranialmagnetic stimulation (nTMS)

►MRI-unit: 3T Philips Achieva, 1.5T Siemens Avanto, 1.5T Siemens Aera

►Co-op with prof Hilkka Soininen, Alzheimer’s disease and memory disorders

►My goal in ASL: understanding of basics, clinical and scientificapplications, problem solving, group level analysis

Research interests

IQ for MR

Bias correction, ASL

IQ for interventional radiology

Artifact suppression, noise/dose reduction,

reconstruction

Dr Hélène LANGET

Research scientist

Philips Research France

Selected publicationsCurriculum

Research scientist (since May 2013)

Philips Research Paris

Ph.D, Engineering Sciences (Mar. 2013)

Ecole Centrale Paris / Supélec / GE Healthcare

Sampling and Motion reconstruction in

Rotational Angiography

Master's degree in Engineering (Sep. 2009)

Télécom Bretagne

11/10/2013

13

Yawu Liu MD, PhD, Adjunct professor

Departments of Radiology and Neurology

University of Eastern Finland

Study Interests: Imaging neurodegenerative diseases

Virginia Mato Abad, PostDoc Student

Laboratory of Neuroimaging at Fundación CIEN-Fundación Reina Sofía in Madrid (Spain)

Research Centre in Neurological and Neurodegenerative Diseases

Neuroimaging post-processing techniques:

• Research software package for analysis and post-processing of ASL studies

• MRS-MRI integration for quantification with partial volume effect correction

11/10/2013

14

http://xnat.org

� XNAT server

� DICOM server

� Web interface

� Access control

Se

gT1m

apAS

L

CB

F

CB

FT1w Pa

r

Pipelines for ASL anayalsis in dementia – Andrew Melbourne

Serena Monti

• Master degree at University of Naples “Federico II” in

Biomedical Engineering

• September 2011- February 2012: Research in 3D/2D

image registration at the “Universidad Politecnica”

of Madrid

• Since February 2013: Researcher at “Fondazione SDN”

of Naples:

� Methods for non-invasive quantitative

assesment of fatty liver and fibrosis

� Novice at ASL

11/10/2013

15

Page 29DZNE e. V. – Magdeburg / iNET

Ruth Oliver

I am:

• a second year Phd

student…

• an image processing

physicist

My research interests are:

• improving quantification

• partial volume correction

Come to my talk on

Friday!

11/10/2013

16

Research interests: To understand the physiological

basis of MRI measurements by combining

conventional with non-conventional sequences.

We are interested in ASL as an alternative to the

resting -state paradigm in order to measure

“cognition”.

Deborah Pareto Onghena (Physicist, PhD)

MRI Research Unit, Vall d’Hebron Hospital

Barcelona (Spain)

Joana Pinto

Bachelor and Master in Biomedical Engineering

Instituto Superior Técnico, Universidade de Lisboa, Portugal

Research Assistant

Institute for Systems and Robotics, Department of Bioengineering,

Instituto Superior Técnico, Universidade de Lisboa, Portugal

Main Research Interests:

Baseline perfusion and cerebrovascular reactivity:

- BOLD and ASL contrasts

- Noninvasive respiratory challenges

- Applications in small vessel disease

2007-2012

2013 -

11/10/2013

17

PhD. Brain Anatomical Connectivity & Cortical

surface parcellation on heatlhy subjects

Research Interests: Clinical applications of anatomical & functional MRIInterface between clinical / methodological / industrial research

Pauline ROCA

From 2011. Research engineer

Abnormal sulco-gyral patterns in epilepsy

MR Flow imaging, sickle-cell disorder

Post-Doc. 4D MR Flow imaging in brainvascular malformations

Sven RothlübbersPhysicist, PhD Student

Experience:

• EEG-fMRI

• Ultrasound Motion Tracking

Working Area:

• MR + Ultrasound

• Motion Detection

Interest:

• ASL + Motion Correction

11/10/2013

18

Combination of DTI and ASL for Brain Tumor studies

Radiology and Tumor Immunology Departments

Radboud University Medical Centre

Nijmegen, The Netherlands

11/10/2013

19

Arnold Skimminge

• Physicist

• 10 years experience

with MRI

• Acquisition and

preprocessing of

imaging data

11/10/2013

20

Page 39

Inês Sousa

Researcher

Siemens Healthcare and Bioengineering Department of University of Lisbon

PhD in Biomedical Engineering (2013)

PhD Thesis:

Development of Quantitative Methods for Functional Magnetic Resonance Imaging

Research Interests:

• Quantitative fMRI

• Non-invasive assessment of

cerebrovascular reactivity using ASL

and BOLD

• ASL reproducibility studies

Marta Vidorreta, PhD Student

Neuroimaging Laboratory at CIMA

Optimization of ASL readout sequences

Parkinson’s

Disease

Alzheimer’s

Disease

11/10/2013

21

• Medical Doctor and PhD-student at Uppsala University hospital in Sweden.

• Working with normal pressure hydrocephalus (NPH), a condition associated with dementia, gait disturbance and urinary incontinence in the elderly.

• Ongoing research about the cerebral perfusion of patients with NPH.

• Perfusion measured with pseudo-continuous ASL.

• Comparisons with healthy controls.

• Baseline investigations with intervals 1 hour and 3 months.

• Investigations before and after drainage of cerebrospinal fluid with lumbar puncture and before and after implantation of a ventriculoperitoneal shunt.

Johan VirhammarCBF in normal pressure hydrocephalus

Yolanda Vives Gilabert

- Telecommunication's engineer and PhD in Electromagnetics- Coordinator of the Medical Imaging Group at Port d'Informació Científica (PIC), Autonomous University of Barcelona, Spain- PIC is a data center with more than 4.000 cores, 5.700 TB of disk and 6.800 TB of tape for the storage

Main interests:

- Processing of large datasets of MRIs and PETs - Analysis of fMRI, DTI and ASL studies- Application of classification methods (bayesian classifiers, SVM ...)- Pathologies: depression, schizophrenia, Alzheimer's and Parkinson's disease, multiple sclerosis, ADHD

PIC

port d’informació

científica

11/10/2013

22

Linda Vriend, 23

Medical student

Erasmus University Rotterdam

Master

Research: Cognitive function in HIV

patients

Grey matter(s)!

MRI physicist post-doc in the Department of

Neuroimaging at King’s College London working

on:

– Simultaneous BOLD-ASL for quantitation of

CMRO2, OEF etc…

– Resting-state FMRI

– Pulse sequence programming and RF pulse

design

Dr Stephen Wastling

11/10/2013

23

Dr Roman Wesolowski, Ph.D. Eng.

King’s College London

Main areas of interest

• Clinical applications of ASL

• Cardiac perfusion

• Validation in animal models

• Sequence and post-processing development of ASL-based

techniques

• Quantification

Fernando Zelaya

Reader in Physiological Neuroimaging,

Department of Neuroimaging, King’s College London

Main areas of research:

- Application of ASL and BOLD fMRI techniques to the study of brain physiology,

appetite control and pharmacology

- Development of analysis methods for group analysis of ASL data

- Refinement of ASL pre-processing methods for spatial normalisation

-Application ASL and relaxometry techniques in vascular disease

- Pulse sequence design for new ASL methods