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Page 1: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

02. 09. 2013.

Page 2: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

biofizika.aok.pte.hu/en

Biophysics I.

• Compulsory subject

• Course Leader: Dr. Miklós Nyitrai

• 2 lectures and 2 practicals/week

• Midterm test: 1 written test

• Exam: oral exam

• Location and time:

• Lectures: Main Building, Lecture room ?, Tue, Wed:

11:00-12:00

• Laboratory practicals: Department of Biophysics Practical

Rooms, see Timetable for details.

Page 3: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Facultative subject

1 credit point

Course Leader: Dr. András Lukács

([email protected])

1 seminar / week

Grade based on final test written at the end of

the course

Page 4: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr
Page 5: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Prediction and determination of the

protein stucture

Single molecule spectroscopy

Molecular motors

Folding of protein

Protein-Protein, Protein-DNA interaction

Page 6: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Structure and properites of cell membrane Transport in/through cell membrane Cell division Movement of cell, cytoskeleton Propagation of action potential

Physiology

Biomechanics

„ Tissue and biomedical engineering”

Page 7: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Introduction Sep 2,3,4

The structure of membranes, resting potential, action potential Sep 9,10,11

Vision, Hearing Sep 16,17,18

Cytoskeleton, motor proteins, muscle contraction Sep 23,24,25

Structure and mechanics of striated muscle Sep 30, Oct 1, okt2

Laws of thermodynamics Oct 7,8,9

Diffusion, osmosis Oct 14,15,16

Fluid flow, Biophysics of circulation. Cardiac biophysics Oct 21, 22,

Electromagnetic waves Oct 28, 29, 30

Foundations of quantum physics Nov 4,5,6

Laser Nov 11,12,13

Test Nov 18,19,20

Biological effects of radioactive radiation Nov 25, 26, 27

X-ray, X-ray diffraction Dec 2,3,4

Page 8: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Investigating the actin-binding proteins by biophysical methods

Supervisor: Dr. Gábor Hild associate professor

Molecular basis of the functional polymorphism of the actin

cytoskeleton: the role of protein isoforms

Supervisor: Dr. Beáta Bugyi assistant professor

How to reconstruct a cell: biomimetic model systems, Supervisor: Dr.

Beáta Bugyi assistant professor

Biological role of SALS in Drosophila embryogenesis, Supervisor: Dr.

Beáta Bugyi assistant professor (in collaboration with József Mihály,

Institute of Genetics, Biological Research Centre, Hungarian Academy of

Sciences, Szeged, Hungary)

Regulation of Actin Cytoskeleton in Cell Protrusions, Supervisor: Dr.

Balázs Visegrády assistant professor

Page 9: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

The Role of MAL in Actin-activated SRF Gene Transcription Supervisor: Dr.

Balázs Visegrády assistant professor

Study of photoactive flavoproteins by the means of ultrafast laser and

fluorescence spectroscopy

Supervisor: Dr. András Lukács assistant professor, Dr. József Orbán assistant

professor

Study of cytoskeletal proteins by the means of fluorescence lifetime imaging

microscopy (FLIM)

Supervisor: Dr. András Lukács assistant professor

Investigation of thermal stability of macromolecules having biological

importance

Supervisor: Dr. Dénes Lőrinczy

New direct communication pathways between the cells. Study of nanotubes by

microscopy, Supervisor: Dr. Edina Szabó-Meleg, assistant lecturer

Superresolution microscopy applied for the discovery of intercellular

communication, Supervisor: Dr. Edina Szabó-Meleg, assistant lecturer, Dr.

József Orbán, assistant professor

Page 10: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Basic physical quantities – These cannot be defined by other

physical quantities.

Page 11: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

SI/metric -prefixes

Name Symbole Prefix

yotta- Y 1024

zetta- Z 1021

exa- E 1018

peta- P 1015

tera- T 1012

giga- G 109

mega- M 106

kilo- k 10³

hecto- h 10²

deka- da (dk) 101

– – 100

deci- d 10−1

centi- c 10−2

milli- m 10−3

micro- µ 10−6

nano- n 10−9

piko- p 10−12

femto- f 10−15

atto- a 10−18

zepto- z 10−21

yokto- y 10−24

Page 12: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

SCALAR VECTOR

It has magnitude. Number

E.g.: mass

length

charge

It has magnitude and

direction

E.g.: velocity

force

acceleration

Page 13: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

Properties:

http://users.atw.hu/mgvacmatek/expfv.pdf

Page 14: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr

logab=c →ac=b

Natural logarithm Common logarithm

Page 15: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr
Page 16: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr
Page 17: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr
Page 18: 02. 09. 2013. - biofizika2.aok.pte.hubiofizika2.aok.pte.hu/tantargyak/files/seminar1/2013-2014/seminar1... · 02. 09. 2013. biofizika.aok.pte.hu/en Biophysics I. ... Supervisor: Dr