“ working with the web-database and biobanking ” medicel meeting 2011 bologna. april 5 2011
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“ Working with the web-database and Biobanking ” MEDICEL meeting 2011 Bologna. April 5 2011 . Jose Ramon Bilbao. The MediCel database… a newborn project http//medicel.sedyne.org. The MediCel database… a newborn project http//medicel.sedyne.org. it needs to grow . - PowerPoint PPT PresentationTRANSCRIPT
“Working with the web-database andBiobanking”
MEDICEL meeting 2011Bologna. April 5 2011
Jose Ramon Bilbao
The MediCel database… a newborn projecthttp//medicel.sedyne.org
The MediCel database… a newborn projecthttp//medicel.sedyne.org
it needs to grow
The MediCel database… a newborn projecthttp//medicel.sedyne.org
request for access…
The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your country
The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
you can only do two things now…
The MediCel database… a newborn projecthttp//medicel.sedyne.org
type your name
The MediCel database… a newborn projecthttp//medicel.sedyne.org
The MediCel database… a newborn projecthttp//medicel.sedyne.org
This is an anonymous databaseSamples are coded: country_XX
The MediCel database… a newborn projecthttp//medicel.sedyne.org
This is an anonymous databaseSamples are coded: country_XX
You should have your code safe with youcountry_XX = patient ID
The MediCel database… a newborn projecthttp//medicel.sedyne.org
This is an anonymous databaseSamples are coded: country_XX
This will be important for follow-up…
You should have your code safe with youcountry_XX = patient ID
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will check
The MediCel database… a newborn projecthttp//medicel.sedyne.org
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will check
“Lab” results
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will checkShould addrapid test (+/-)?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will check
Biological material
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will check
Is this realistic?
• Fixed?• Frozen?• Slide?• Paraffin block?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
Or should we share “image files” with
consultant pathologists
The MediCel database… a newborn projecthttp//medicel.sedyne.org
Or should we share “image files” with
consultant pathologists
we are implementing an image repository to upload images for training and for consultation
The MediCel database… a newborn projecthttp//medicel.sedyne.org
Or should we share “image files” with
consultant pathologists
we are implementing an image repository to upload images for training and for consultation
we need them!!
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
CELI-BANK
…what for?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
CELI-BANK
…what for?
RESEARCH!
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkAre we going to “store/share”?
CELI-BANK
…what for?
RESEARCH! and…
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
…but are they necessary?Confirm rapid testsunclear results
Reference Laboratory
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkGenetic studies?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?
Provide affordableHLA testing
SNP-basedDQ2.5DQ2.2DQ8
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?Provide affordable
HLA testing
DNAbank
The MediCel database… a newborn projecthttp//medicel.sedyne.org
All fields are (*) compulsory!
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?
Provide affordableHLA testing
Or should we share “image files” with
consultant pathologistsCould these two ideas be the basis for a
collaborative project?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?symptoms/signs
The MediCel database… a newborn projecthttp//medicel.sedyne.org
is age at Dx enough?
…but are they necessary?
…will checkProvide HLA testing
SNP-basedDQ2.5DQ2.2DQ8
other genetic studies?symptoms/signs
are we happy?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
symptoms/signs
are we happy?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
symptoms/signs
are we happy?
The MediCel database… a newborn projecthttp//medicel.sedyne.org
symptoms/signs
are we happy?
…let us know
The MediCel database… a newborn projecthttp//medicel.sedyne.org
The MediCel database… a newborn projecthttp//medicel.sedyne.org
The MediCel database… a newborn projecthttp//medicel.sedyne.org
544 patients!
The MediCel database… a newborn projecthttp//medicel.sedyne.org
544 patients!
270 w/out HLA typing!
The MediCel database… a newborn projecthttp//medicel.sedyne.org
544 patients!
270 w/out HLA typing! …should we?
The MediCel database… what next?http//medicel.sedyne.org
type your name
…we want to do more than just two things
The MediCel database… what next?http//medicel.sedyne.org
type your name
…we want to do more than just two things
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD
- confirmed? - doubtful?
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD
- confirmed? - doubtful?
seek help from the “experts”…through the database
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information
- associated diseases- re-testing of TGA- re-byopsying
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images
linked to patient data
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD - confirmed? y/n2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images
linked to patient data
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images5.- “Memo” field to share comments
The MediCel database… what next?http//medicel.sedyne.org
type your name1.- Diagnosis of CD2.- Query/filter/modify patient data3.- Insert follow-up information4.- Enable uploading/viewing of images5.- “Memo” field to share comments
and even more!... just ask [email protected]
Potential R+D Projects in MediCel
Potential R+D Projects in MediCel1. Impact of Information Technologies for diagnosis and follow-up
of CD patientsEstablish a network of “consultants”
PathologyImmunologyGastroenterology…
… working through the MediCel web-database
Potential R+D Projects in MediCel1. Impact of Information Technologies for diagnosis and follow-up
of CD patientsEstablish a network of “consultants”
PathologyImmunologyGastroenterology…
… working through the MediCel web-database
2. Validation of affordable technologies for lab testing in CDa) Retyping of HLA using proxy SNPs to validate in our populations
Set up a reference lab/protocol for typing of new cases w/ SNPsSharing of DNA samples (saliva, blood spots…)
b) Evaluate the performance of point-of-care methods in our settingSet up a reference lab/protocol for validation assaysSharing of serum samples
c) Creation of a BIOBANK through these projects
Potential R+D Projects in MediCel1. Impact of Information Technologies for diagnosis and follow-up
of CD patientsEstablish a network of “consultants”
PathologyImmunologyGastroenterology…
… working through the MediCel web-database
2. Validation of affordable technologies for lab testing in CDa) Retyping of HLA using proxy SNPs to validate in our populations
Set up a reference lab/protocol for typing of new cases w/ SNPsSharing of DNA samples (saliva, blood spots…)
b) Evaluate the performance of point-of-care methods in our settingSet up a reference lab/protocol for validation assaysSharing of serum samples
c) Creation of a BIOBANK through these projects