understand the term syncope. differentiate the serious causes of syncope from those that are...
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Understand the term syncope.
Differentiate the serious causes of syncope from those that are benign.
Know the appropriate testing needed in the evaluation of syncope based upon the presenting history.
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Palpitations - sensation of strong, rapid, or irregular heart beats.
Syncope – transient loss of consciousness and postural tone due to generalized cerebral ischemia with rapid and spontaneous recovery.
Presyncope - no complete loss of consciousness occurs.
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Disorders without impairment of consciousness:
Drop attacks.Cataplexy.Psychogenic pseudo-syncope.Transient ischemic attacks.
Disorders with loss of consciousness:Metabolic disorders.Epilepsy.Intoxications.Vertebrobasilar transient ischemic attacks.
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Affects 15% of children between 8-18 Y
Uncommon under age 7 Y therefore think about:Seizure disorders.Breath holding.Primary cardiac dysrhythmias.
Cardiovascular causes unusual but life-threateningCongenital malformations.Valvular disease.Electrical abnormalities.
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ObservationObservation SeizureSeizure Inadequate Inadequate PerfusionPerfusion
OnsetOnset SuddenSudden More gradualMore gradual
DurationDuration MinutesMinutes SecondsSeconds
JerksJerks FrequentFrequent RareRare
HeadacheHeadache Frequent (after)Frequent (after) Occasional Occasional (before)(before)
Confusion afterConfusion after FrequentFrequent RareRare
IncontinenceIncontinence FrequentFrequent RareRare
Eye deviationEye deviation HorizontalHorizontal Vertical (or none)Vertical (or none)
Tongue bitingTongue biting FrequentFrequent RareRare
ProdromeProdrome AuraAura DizzinessDizziness
EEGEEG Often abnormalOften abnormal Usually normalUsually normal
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OrthostaticOrthostatic CardiacArrhythmia
CardiacArrhythmia
StructuralCardio-
Pulmonary
StructuralCardio-
Pulmonary
1• Vasovagal• Carotid Sinus• Situational
CoughPost- Micturition
2• Drug-Induced• Autonomic
Nervous System FailurePrimarySecondary
3• Brady
SN Dysfunction
AV Block
• TachyVTSVT
• Long QT Syndrome
4 • Acute
Myocardial Ischemia
• Aortic Stenosis
• HCM• Pulmonary
Hypertension• Aortic
Dissection
Neurally-Mediated
Neurally-Mediated
Unexplained Causes = Approximately 1/3Unexplained Causes = Approximately 1/3
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Vasovagal. Situational. Psychiatric. Long QT. WPW syndrome. RV dysplasia. Hypertrophic cardiomyopathy. Catecholaminergic VT. Other genetic syndromes.
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Vasovagal Events:30% to 50% of cases.Decreased PVR.Decreased venous return.Decreased cardiac output.Hypotension.Bradycardia.
In teens – think about pregnancy and drug abuse.
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Is the loss of consciousness attributable to syncope or not?
Is heart disease present or absent?
Are there important clinical features in the history that suggest the diagnosis?
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Questions about circumstances just prior to attack
Position (supine, sitting , standing) Activity (rest, change in posture, during or immediately
after exercise, during or immediately after urination, defecation or swallowing)
Predisposing factors (crowded or warm place, prolonged standing post-prandial period) and of precipitating events (fear, intense pain, neck movements)
Questions about onset of the attack Nausea, vomiting, feeling cold, sweating, pain in chest
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Questions about attack (eye witness): Skin color (pallor, cyanotic). Duration of loss of consciousness. Movements ( tonic-clonic, etc.). Tongue biting.
Questions about the end of the attack: Nausea, vomiting, diaphoresis, feeling
cold, muscle aches, confusion, skin color, wounds.
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Questions about background: Number and duration of syncope spells. Family history of arrhythmic disease or
sudden death. Presence of cardiac disease. Neurological disease. Medications (Hypotensive, negative.
chronotropic and antidepressant agents).
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Neurally-Mediated Syncope: Absence of cardiac disease. Long history of syncope. After sudden unexpected, unpleasant
sensation. Prolonged standing in crowded, hot
places. Nausea vomiting associated with
syncope During or after a meal. With head rotation or pressure on
carotid sinus. After exertion.
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Syncope due to orthostatic hypotension:
After standing up. Temporal relationship to taking a
medication that can cause hypotension. Prolonged standing. Presence of autonomic neuropathy. After exertion.
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Cardiac Syncope: Presence of structural heart disease. With exertion or supine. Preceded by palpitations. Family history of sudden death.
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Vital signs:Heart rate.Orthostatic blood pressure change.
Cardiovascular exam: Is heart disease present? ECG: Long QT, pre-excitation, conduction system
disease.Echo: LV function, valve status, HCM.
Neurological exam.
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Classically, abnormal if systolic BP decreases by more than 20 points and/or pulse. increases in pulse rate of more than 20 beats per minute after a change from supine to standing.
If there is only a pulse increase but no drop in blood pressure, the test is less significant.
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Distinguish true syncope from syncope mimics.
Determine presence of heart disease and risk for sudden death.
Establish the cause of syncope with sufficient certainty to:Assess prognosis confidently. Initiate effective preventive treatment.
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Survival with and without syncope (adults and children).
6-month mortality rate of greater than 10%.
Cardiac syncope doubled the risk of death.
Includes cardiac arrhythmias.
No SyncopeVasovagal/otherCardiac Cause
0 5 1015Follow-Up (yr)
Pro
bab
ility
of
Sur
viva
l
1.0
0.8
0.6
0.4
0.2
0.0
Soteriades ES, et al. N Engl J Med. 2002;347:878.
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Yield for specific diagnosis low (5%).
Risk free and relatively inexpensive.
Abnormalities (BBB, previous MI, nonsustained VT) guide further evaluation.
Recommended in almost all patients.
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Routine use not recommendedMay be glucose?
Should be done only if specifically suggested by H&P.
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EEG - not useful unless seizures.
Brain imaging - not useful unless focality.
Neurovascular studies.No studies.May be useful if bruits, or hx suggests
vertebrobasilar insufficiency.
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History is key!!!! Orthostatics:
take the time to do them correctly. Cardiac vs Non-cardiac:
If you are not confident that it is NOT cardiac REFER.
ECGUse it if you got ‘em!
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11-year-old girl passed out during reading; awoke after 3 min.
She was stiff with eyes rolled back ~ approx. 3 min.
Now awake and alert; no retractions; skin color is normal.
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Normal appearance, normal breathing, normal circulation.
Vital signs: HR 70; RR 20; BP 90/60; T 37.7 C Wt 39 kg; O2 sat 99%.
Three similar episodes; Preceded by palpitations ,one of them associated with “exercise.”
PMH and FH: Negative.
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What is your general impression of this patient?
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Loss of consciousness. Lasted only a few minutes. Minimal or no postictal state. No stigmata of seizure: Urinary
incontinence, bitten tongue, witnessed tonic-clonic activity.
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Is the loss of consciousness attributable to syncope or not?
Is heart disease present or absent?
Are there important clinical features in the history that suggest the diagnosis?
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StablePatient with syncope. In no distress; normal exam.Concerning/ominous history.
What are your initial management priorities?
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Laboratory is often normal but may include: Electrolytes / Ca++, Mg++, PO4.
CBC with differential. cardiac enzyme.
Radiology: CXR offers little. CT or MRI of the brain and neck may be
indicated if considering seizures or injury
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ECG/Holter. Echocardiography Cardiac MRI Continuous cardiac monitoring EEG Genetic testing Stress ECG
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Differntial diagnosis : Structural heart defect :• Known Congenital heart disease (Ebstein’s
anomaly,LTGA,ASD)• Hypertrophic cardiomyopathy• Anomalous origin of the LCA• Myocarditis • Arrhythmogenic RV dysplasia• Coronary artery disease• Primary or secondary pulmonary hypertension.
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Normal heart structure. WPW syndrome. Long or short QT syndrome. Brugada syndrome. CPVT.
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QT (corrected)
QTc= QT (msec) √R-R (sec)
= 640/ 1.05
= 610 msec
> 450 m sec is long
Long QT syndrome (Jervell-Nielson-Lange)
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Inherited genetic disorder that puts the child at risk for paroxysmal ventricular tachcardia /ventricular fibrillation and sudden death.
May also result from electrolyte imbalance, malnutrition (anorexia and bulimia), myocarditis and CNS trauma
Speculation that it may be associated with SIDS (unproven)
No warning; results in death.
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Long QT syndrome:Congenital long QT associated with hypertrophic
cardiomyopathy.Long QT defined as corrected QT longer than 0.44 sT wave alternans sometimes present.Can have normal ECG in the department.Two clinical syndromes not associated with
structural heart disease: Romano-Ward and Jervell-Lange-Nielsen.
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