p10: statistical analysis of non-neoplastic lesionsmax-iso-poly-3 p
TRANSCRIPT
![Page 1: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/1.jpg)
F1_Rev.1_R2NTP Study Number: C20209
Lock Date: 12/07/2005
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 3.0.2.0_001
PWG Approval Date: NONE
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
![Page 2: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/2.jpg)
MALE RATS
Organ MorphologyEpididymis HypospermiaHeart CardiomyopathyLiver: Hepatocyte Hypertrophy
Vacuolization CytoplasmicLung Inflammation ChronicLung: Alveolar Epithelium HyperplasiaStomach, Glandular ErosionThyroid Gland: Follicle Hypertrophy
FEMALE RATS
Organ MorphologyEye Developmental MalformationLiver Basophilic FocusLiver: Hepatocyte Hypertrophy
Vacuolization CytoplasmicLung Inflammation ChronicStomach, Glandular ErosionThymus AtrophyThyroid Gland: Follicle Hypertrophy
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF PENTABROMODIPHENYL OXIDE (TECHNICAL) (DE 71)
Page 2
![Page 3: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/3.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Adrenal CortexAccessory Adrenal Cortical Nodule
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/2.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 3
![Page 4: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/4.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Bone MarrowHyperplasia
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 2/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 20%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.227
POLY 1.5 (e) (e) (e) (e) (e) P=0.227
POLY 6 (e) (e) (e) (e) (e) P=0.227
COCH-ARM / FISHERS P=0.186 (e) (e) (e) (e) P=0.237
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.066
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 4
![Page 5: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/5.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
EpididymisHypospermia
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 9/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 90%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) (e) (e) (e) P<0.001**
POLY 1.5 P<0.001** (e) (e) (e) (e) P<0.001**
POLY 6 P<0.001** (e) (e) (e) (e) P<0.001**
COCH-ARM / FISHERS P<0.001** (e) (e) (e) (e) P<0.001**
MAX-ISO-POLY-3 P<0.001** (e) (e) (e) (e) P<0.001**
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 5
![Page 6: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/6.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
EyeDevelopmental Malformation
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 6
![Page 7: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/7.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Harderian GlandInflammation Chronic
LESION RATES
OVERALL (a) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 1/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 10% 0% 0% 0% 0% 0%
TERMINAL (d) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500N
POLY 1.5 (e) (e) (e) (e) (e) P=0.500N
POLY 6 (e) (e) (e) (e) (e) P=0.500N
COCH-ARM / FISHERS P=0.419N (e) (e) (e) (e) P=0.500N
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.158N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 7
![Page 8: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/8.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
HeartCardiomyopathy
LESION RATES
OVERALL (a) 3/10 (30%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 3/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 30% 0% 0% 0% 0% 0%
TERMINAL (d) 3/10 (30%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.095N
POLY 1.5 (e) (e) (e) (e) (e) P=0.095N
POLY 6 (e) (e) (e) (e) (e) P=0.095N
COCH-ARM / FISHERS P=0.084N (e) (e) (e) (e) P=0.105N
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.025N*
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 8
![Page 9: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/9.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
KidneyInfiltration Cellular Mononuclear Cell
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 9
![Page 10: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/10.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
KidneyNephropathy
LESION RATES
OVERALL (a) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%)
POLY-3 RATE (b) 1/10.00 0/0.00 0/0.00 0/0.00 0/0.00 2/10.00
POLY-3 PERCENT (g) 10% 0% 0% 0% 0% 20%
TERMINAL (d) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%)
FIRST INCIDENCE 93 (T) --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500
POLY 1.5 (e) (e) (e) (e) (e) P=0.500
POLY 6 (e) (e) (e) (e) (e) P=0.500
COCH-ARM / FISHERS P=0.450 (e) (e) (e) (e) P=0.500
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.274
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 10
![Page 11: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/11.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LiverBasophilic Focus
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 11
![Page 12: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/12.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LiverHepatodiaphragmatic Nodule
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/10.00 1/10.00 1/10.00 0/10.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 10% 10% 0% 10%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%) 0/10 (0%) 1/10 (10%)
FIRST INCIDENCE --- --- 93 (T) 93 (T) --- 93 (T)
STATISTICAL TESTS
POLY 3 P=0.465 (e) P=0.500 P=0.500 (e) P=0.500
POLY 1.5 P=0.465 (e) P=0.500 P=0.500 (e) P=0.500
POLY 6 P=0.465 (e) P=0.500 P=0.500 (e) P=0.500
COCH-ARM / FISHERS P=0.464 (e) P=0.500 P=0.500 (e) P=0.500
MAX-ISO-POLY-3 P=0.158 (e) P=0.158 P=0.158 (e) P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 12
![Page 13: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/13.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LiverNecrosis Focal
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 2/10 (20%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 1/10.00 2/10.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 10% 20% 10%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 2/10 (20%) 1/10 (10%)
FIRST INCIDENCE --- --- --- 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P=0.372 (e) (e) P=0.500 P=0.227 P=0.500
POLY 1.5 P=0.372 (e) (e) P=0.500 P=0.227 P=0.500
POLY 6 P=0.372 (e) (e) P=0.500 P=0.227 P=0.500
COCH-ARM / FISHERS P=0.371 (e) (e) P=0.500 P=0.237 P=0.500
MAX-ISO-POLY-3 P=0.090 (e) (e) P=0.158 P=0.066 P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 13
![Page 14: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/14.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Liver: HepatocyteHypertrophy
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 9/10 (90%) 10/10 (100%) 10/10 (100%) 10/10 (100%)
POLY-3 RATE (b) 0/10.00 0/10.00 9/10.00 10/10.00 10/10.00 10/10.00
POLY-3 PERCENT (g) 0% 0% 90% 100% 100% 100%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 9/10 (90%) 10/10 (100%) 10/10 (100%) 10/10 (100%)
FIRST INCIDENCE --- --- 93 (T) 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) P<0.001** P<0.001** P<0.001** P<0.001**
POLY 1.5 P<0.001** (e) P<0.001** P<0.001** P<0.001** P<0.001**
POLY 6 P<0.001** (e) P<0.001** P<0.001** P<0.001** P<0.001**
COCH-ARM / FISHERS P<0.001** (e) P<0.001** P<0.001** P<0.001** P<0.001**
MAX-ISO-POLY-3 P<0.001** (e) P<0.001** (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 14
![Page 15: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/15.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Liver: HepatocyteVacuolization Cytoplasmic
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 10/10.00 10/10.00 10/10.00
POLY-3 PERCENT (g) 0% 0% 0% 100% 100% 100%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) 10/10 (100%) 10/10 (100%)
FIRST INCIDENCE --- --- --- 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) (e) P<0.001** P<0.001** P<0.001**
POLY 1.5 P<0.001** (e) (e) P<0.001** P<0.001** P<0.001**
POLY 6 P<0.001** (e) (e) P<0.001** P<0.001** P<0.001**
COCH-ARM / FISHERS P<0.001** (e) (e) P<0.001** P<0.001** P<0.001**
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 15
![Page 16: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/16.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LungHemorrhage
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 10% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- 93 (T) ---
STATISTICAL TESTS
POLY 3 P=0.858N (e) (e) (e) P=0.500 (e)
POLY 1.5 P=0.858N (e) (e) (e) P=0.500 (e)
POLY 6 P=0.858N (e) (e) (e) P=0.500 (e)
COCH-ARM / FISHERS P=0.860N (e) (e) (e) P=0.500 (e)
MAX-ISO-POLY-3 P=0.193 (e) (e) (e) P=0.158 (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 16
![Page 17: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/17.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LungInfiltration Cellular Histiocyte
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 10% 10%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P=0.236 (e) (e) (e) P=0.500 P=0.500
POLY 1.5 P=0.236 (e) (e) (e) P=0.500 P=0.500
POLY 6 P=0.236 (e) (e) (e) P=0.500 P=0.500
COCH-ARM / FISHERS P=0.232 (e) (e) (e) P=0.500 P=0.500
MAX-ISO-POLY-3 P=0.109 (e) (e) (e) P=0.158 P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 17
![Page 18: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/18.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LungInflammation Chronic
LESION RATES
OVERALL (a) 2/10 (20%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
POLY-3 RATE (b) 2/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00
POLY-3 PERCENT (g) 20% 0% 0% 0% 0% 0%
TERMINAL (d) 2/10 (20%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- --- --- ---
STATISTICAL TESTS
POLY 3 P=0.469N P=0.227N P=0.227N P=0.227N P=0.227N P=0.227N
POLY 1.5 P=0.469N P=0.227N P=0.227N P=0.227N P=0.227N P=0.227N
POLY 6 P=0.469N P=0.227N P=0.227N P=0.227N P=0.227N P=0.227N
COCH-ARM / FISHERS P=0.471N P=0.237N P=0.237N P=0.237N P=0.237N P=0.237N
MAX-ISO-POLY-3 P=0.005N** P=0.066N P=0.066N P=0.066N P=0.066N P=0.066N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 18
![Page 19: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/19.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lung: Alveolar EpitheliumHyperplasia
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 10%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 P=0.142 (e) (e) (e) (e) P=0.500
POLY 1.5 P=0.142 (e) (e) (e) (e) P=0.500
POLY 6 P=0.142 (e) (e) (e) (e) P=0.500
COCH-ARM / FISHERS P=0.140 (e) (e) (e) (e) P=0.500
MAX-ISO-POLY-3 P=0.041* (e) (e) (e) (e) P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 19
![Page 20: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/20.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: MediastinalHemorrhage
LESION RATES
OVERALL (a) 0/0 (0%) 0/1 (0%) 0/0 (0%) 1/1 (100%) 1/1 (100%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/1.00 0/0.00 1/1.00 1/1.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 0% 100% 100% 0%
TERMINAL (d) 0/0 (0%) 0/1 (0%) 0/0 (0%) 1/1 (100%) 1/1 (100%) 0/0 (0%)
FIRST INCIDENCE --- --- --- 93 (T) 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000 (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 20
![Page 21: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/21.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: MediastinalHyperplasia Lymphoid
LESION RATES
OVERALL (a) 0/0 (0%) 0/1 (0%) 0/0 (0%) 1/1 (100%) 1/1 (100%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/1.00 0/0.00 1/1.00 1/1.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 0% 100% 100% 0%
TERMINAL (d) 0/0 (0%) 0/1 (0%) 0/0 (0%) 1/1 (100%) 1/1 (100%) 0/0 (0%)
FIRST INCIDENCE --- --- --- 93 (T) 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000 (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 21
![Page 22: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/22.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: PancreaticHemorrhage
LESION RATES
OVERALL (a) 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/1 (0%) 0/1 (0%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 1/1.00 0/0.00 0/1.00 0/1.00 0/0.00
POLY-3 PERCENT (g) 0% 100% 0% 0% 0% 0%
TERMINAL (d) 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/1 (0%) 0/1 (0%) 0/0 (0%)
FIRST INCIDENCE --- 93 (T) --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000N (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 22
![Page 23: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/23.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: PancreaticHyperplasia Lymphoid
LESION RATES
OVERALL (a) 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/1 (0%) 0/1 (0%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 1/1.00 0/0.00 0/1.00 0/1.00 0/0.00
POLY-3 PERCENT (g) 0% 100% 0% 0% 0% 0%
TERMINAL (d) 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/1 (0%) 0/1 (0%) 0/0 (0%)
FIRST INCIDENCE --- 93 (T) --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000N (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 23
![Page 24: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/24.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: PancreaticPigmentation
LESION RATES
OVERALL (a) 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/1 (0%) 0/1 (0%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/1.00 0/0.00 0/1.00 0/1.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/0 (0%) 0/1 (0%) 0/0 (0%) 0/1 (0%) 0/1 (0%) 0/0 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 24
![Page 25: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/25.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Mesentery: FatNecrosis
LESION RATES
OVERALL (a) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/0.00 0/0.00 0/0.00 0/0.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 25
![Page 26: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/26.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Pituitary Gland: Pars DistalisCyst
LESION RATES
OVERALL (a) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 1/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 10% 0% 0% 0% 0% 0%
TERMINAL (d) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500N
POLY 1.5 (e) (e) (e) (e) (e) P=0.500N
POLY 6 (e) (e) (e) (e) (e) P=0.500N
COCH-ARM / FISHERS P=0.419N (e) (e) (e) (e) P=0.500N
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.158N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 26
![Page 27: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/27.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Salivary GlandsNecrosis
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 10%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500
POLY 1.5 (e) (e) (e) (e) (e) P=0.500
POLY 6 (e) (e) (e) (e) (e) P=0.500
COCH-ARM / FISHERS P=0.419 (e) (e) (e) (e) P=0.500
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 27
![Page 28: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/28.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Stomach, GlandularErosion
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 1/10 (10%) 2/10 (20%) 3/10 (30%) 4/10 (40%)
POLY-3 RATE (b) 0/10.00 0/10.00 1/10.00 2/10.00 3/10.00 4/10.00
POLY-3 PERCENT (g) 0% 0% 10% 20% 30% 40%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 1/10 (10%) 2/10 (20%) 3/10 (30%) 4/10 (40%)
FIRST INCIDENCE --- --- 93 (T) 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P=0.013* (e) P=0.500 P=0.227 P=0.095 P=0.033*
POLY 1.5 P=0.013* (e) P=0.500 P=0.227 P=0.095 P=0.033*
POLY 6 P=0.013* (e) P=0.500 P=0.227 P=0.095 P=0.033*
COCH-ARM / FISHERS P=0.015* (e) P=0.500 P=0.237 P=0.105 P=0.043*
MAX-ISO-POLY-3 P=0.006** (e) P=0.158 P=0.066 P=0.025* P=0.007**
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 28
![Page 29: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/29.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Stomach, Glandular: GlandsDilatation
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 29
![Page 30: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/30.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
ThymusAtrophy
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/9.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 30
![Page 31: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/31.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
ThymusHemorrhage
LESION RATES
OVERALL (a) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%)
POLY-3 RATE (b) 1/10.00 0/10.00 0/10.00 0/10.00 1/10.00 0/9.00
POLY-3 PERCENT (g) 10% 0% 0% 0% 10% 0%
TERMINAL (d) 1/10 (10%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/9 (0%)
FIRST INCIDENCE 93 (T) --- --- --- 93 (T) ---
STATISTICAL TESTS
POLY 3 P=0.651N P=0.500N P=0.500N P=0.500N P=0.760 P=0.521N
POLY 1.5 P=0.651N P=0.500N P=0.500N P=0.500N P=0.760 P=0.521N
POLY 6 P=0.651N P=0.500N P=0.500N P=0.500N P=0.760 P=0.521N
COCH-ARM / FISHERS P=0.654N P=0.500N P=0.500N P=0.500N P=0.763N P=0.526N
MAX-ISO-POLY-3 P=0.124N P=0.158N P=0.158N P=0.158N P=1.000 P=0.178N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 31
![Page 32: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/32.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Thyroid Gland: FollicleHypertrophy
LESION RATES
OVERALL (a) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 9/10 (90%)
POLY-3 RATE (b) 0/10.00 0/9.00 0/10.00 0/10.00 1/10.00 9/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 10% 90%
TERMINAL (d) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 9/10 (90%)
FIRST INCIDENCE --- --- --- --- 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) (e) (e) P=0.500 P<0.001**
POLY 1.5 P<0.001** (e) (e) (e) P=0.500 P<0.001**
POLY 6 P<0.001** (e) (e) (e) P=0.500 P<0.001**
COCH-ARM / FISHERS P<0.001** (e) (e) (e) P=0.500 P<0.001**
MAX-ISO-POLY-3 P<0.001** (e) (e) (e) P=0.158 P<0.001**
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Males
Page 32
![Page 33: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/33.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Adrenal CortexAccessory Adrenal Cortical Nodule
LESION RATES
OVERALL (a) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 1/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 10% 0% 0% 0% 0% 0%
TERMINAL (d) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500N
POLY 1.5 (e) (e) (e) (e) (e) P=0.500N
POLY 6 (e) (e) (e) (e) (e) P=0.500N
COCH-ARM / FISHERS P=0.419N (e) (e) (e) (e) P=0.500N
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.158N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 33
![Page 34: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/34.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Bone MarrowHyperplasia
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 34
![Page 35: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/35.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Clitoral GlandInflammation Chronic
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 2/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 20%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.227
POLY 1.5 (e) (e) (e) (e) (e) P=0.227
POLY 6 (e) (e) (e) (e) (e) P=0.227
COCH-ARM / FISHERS P=0.186 (e) (e) (e) (e) P=0.237
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.066
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 35
![Page 36: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/36.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
EyeDevelopmental Malformation
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 1/1.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 100% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) P=0.091 (e)
POLY 1.5 (e) (e) (e) (e) P=0.091 (e)
POLY 6 (e) (e) (e) (e) P=0.091 (e)
COCH-ARM / FISHERS P=0.594N (e) (e) (e) P=0.091 (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) P<0.001** (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 36
![Page 37: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/37.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Harderian GlandInflammation Chronic
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 37
![Page 38: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/38.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
HeartCardiomyopathy
LESION RATES
OVERALL (a) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 1/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 10% 0% 0% 0% 0% 0%
TERMINAL (d) 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500N
POLY 1.5 (e) (e) (e) (e) (e) P=0.500N
POLY 6 (e) (e) (e) (e) (e) P=0.500N
COCH-ARM / FISHERS P=0.419N (e) (e) (e) (e) P=0.500N
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.158N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 38
![Page 39: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/39.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
KidneyInfiltration Cellular Mononuclear Cell
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 10%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.500
POLY 1.5 (e) (e) (e) (e) (e) P=0.500
POLY 6 (e) (e) (e) (e) (e) P=0.500
COCH-ARM / FISHERS P=0.419 (e) (e) (e) (e) P=0.500
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 39
![Page 40: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/40.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
KidneyNephropathy
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 40
![Page 41: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/41.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LiverBasophilic Focus
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 10%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 P=0.142 (e) (e) (e) (e) P=0.500
POLY 1.5 P=0.142 (e) (e) (e) (e) P=0.500
POLY 6 P=0.142 (e) (e) (e) (e) P=0.500
COCH-ARM / FISHERS P=0.140 (e) (e) (e) (e) P=0.500
MAX-ISO-POLY-3 P=0.041* (e) (e) (e) (e) P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 41
![Page 42: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/42.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LiverHepatodiaphragmatic Nodule
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 10% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- 93 (T) ---
STATISTICAL TESTS
POLY 3 P=0.858N (e) (e) (e) P=0.500 (e)
POLY 1.5 P=0.858N (e) (e) (e) P=0.500 (e)
POLY 6 P=0.858N (e) (e) (e) P=0.500 (e)
COCH-ARM / FISHERS P=0.860N (e) (e) (e) P=0.500 (e)
MAX-ISO-POLY-3 P=0.193 (e) (e) (e) P=0.158 (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 42
![Page 43: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/43.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LiverNecrosis Focal
LESION RATES
OVERALL (a) 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%)
POLY-3 RATE (b) 1/10.00 0/10.00 0/10.00 1/10.00 0/10.00 0/10.00
POLY-3 PERCENT (g) 10% 0% 0% 10% 0% 0%
TERMINAL (d) 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%)
FIRST INCIDENCE 93 (T) --- --- 93 (T) --- ---
STATISTICAL TESTS
POLY 3 P=0.550N P=0.500N P=0.500N P=0.760 P=0.500N P=0.500N
POLY 1.5 P=0.550N P=0.500N P=0.500N P=0.760 P=0.500N P=0.500N
POLY 6 P=0.550N P=0.500N P=0.500N P=0.760 P=0.500N P=0.500N
COCH-ARM / FISHERS P=0.551N P=0.500N P=0.500N P=0.763N P=0.500N P=0.500N
MAX-ISO-POLY-3 P=0.109N P=0.158N P=0.158N P=1.000 P=0.158N P=0.158N
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 43
![Page 44: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/44.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Liver: HepatocyteHypertrophy
LESION RATES
OVERALL (a) 0/10 (0%) 2/10 (20%) 5/10 (50%) 10/10 (100%) 10/10 (100%) 10/10 (100%)
POLY-3 RATE (b) 0/10.00 2/10.00 5/10.00 10/10.00 10/10.00 10/10.00
POLY-3 PERCENT (g) 0% 20% 50% 100% 100% 100%
TERMINAL (d) 0/10 (0%) 2/10 (20%) 5/10 (50%) 10/10 (100%) 10/10 (100%) 10/10 (100%)
FIRST INCIDENCE --- 93 (T) 93 (T) 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** P=0.227 P=0.008** P<0.001** P<0.001** P<0.001**
POLY 1.5 P<0.001** P=0.227 P=0.008** P<0.001** P<0.001** P<0.001**
POLY 6 P<0.001** P=0.227 P=0.008** P<0.001** P<0.001** P<0.001**
COCH-ARM / FISHERS P<0.001** P=0.237 P=0.016* P<0.001** P<0.001** P<0.001**
MAX-ISO-POLY-3 P<0.001** P=0.066 P<0.001** (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 44
![Page 45: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/45.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Liver: HepatocyteVacuolization Cytoplasmic
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) 10/10 (100%) 10/10 (100%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 3/10.00 10/10.00 10/10.00
POLY-3 PERCENT (g) 0% 0% 0% 30% 100% 100%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) 10/10 (100%) 10/10 (100%)
FIRST INCIDENCE --- --- --- 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) (e) P=0.095 P<0.001** P<0.001**
POLY 1.5 P<0.001** (e) (e) P=0.095 P<0.001** P<0.001**
POLY 6 P<0.001** (e) (e) P=0.095 P<0.001** P<0.001**
COCH-ARM / FISHERS P<0.001** (e) (e) P=0.105 P<0.001** P<0.001**
MAX-ISO-POLY-3 P<0.001** (e) (e) P=0.025* (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 45
![Page 46: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/46.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LungHemorrhage
LESION RATES
OVERALL (a) 0/10 (0%) 2/10 (20%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 2/10.00 0/10.00 0/10.00 1/10.00 0/10.00
POLY-3 PERCENT (g) 0% 20% 0% 0% 10% 0%
TERMINAL (d) 0/10 (0%) 2/10 (20%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
FIRST INCIDENCE --- 93 (T) --- --- 93 (T) ---
STATISTICAL TESTS
POLY 3 P=0.463N P=0.227 (e) (e) P=0.500 (e)
POLY 1.5 P=0.463N P=0.227 (e) (e) P=0.500 (e)
POLY 6 P=0.463N P=0.227 (e) (e) P=0.500 (e)
COCH-ARM / FISHERS P=0.464N P=0.237 (e) (e) P=0.500 (e)
MAX-ISO-POLY-3 P=0.149N P=0.066 (e) (e) P=0.158 (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 46
![Page 47: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/47.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LungInfiltration Cellular Histiocyte
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 10% 10%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 P=0.236 (e) (e) (e) P=0.500 P=0.500
POLY 1.5 P=0.236 (e) (e) (e) P=0.500 P=0.500
POLY 6 P=0.236 (e) (e) (e) P=0.500 P=0.500
COCH-ARM / FISHERS P=0.232 (e) (e) (e) P=0.500 P=0.500
MAX-ISO-POLY-3 P=0.109 (e) (e) (e) P=0.158 P=0.158
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 47
![Page 48: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/48.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
LungInflammation Chronic
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 2/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 20%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 P=0.007** (e) (e) (e) (e) P=0.227
POLY 1.5 P=0.007** (e) (e) (e) (e) P=0.227
POLY 6 P=0.007** (e) (e) (e) (e) P=0.227
COCH-ARM / FISHERS P=0.010** (e) (e) (e) (e) P=0.237
MAX-ISO-POLY-3 P=0.005** (e) (e) (e) (e) P=0.066
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 48
![Page 49: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/49.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lung: Alveolar EpitheliumHyperplasia
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 49
![Page 50: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/50.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: MediastinalHemorrhage
LESION RATES
OVERALL (a) 0/0 (0%) 0/0 (0%) 1/2 (50%) 1/1 (100%) 2/2 (100%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/0.00 1/2.00 1/1.00 2/2.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 50% 100% 100% 0%
TERMINAL (d) 0/0 (0%) 0/0 (0%) 1/2 (50%) 1/1 (100%) 2/2 (100%) 0/0 (0%)
FIRST INCIDENCE --- --- 93 (T) 93 (T) 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000 (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 50
![Page 51: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/51.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: MediastinalHyperplasia Lymphoid
LESION RATES
OVERALL (a) 0/0 (0%) 0/0 (0%) 1/2 (50%) 1/1 (100%) 2/2 (100%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/0.00 1/2.00 1/1.00 2/2.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 50% 100% 100% 0%
TERMINAL (d) 0/0 (0%) 0/0 (0%) 1/2 (50%) 1/1 (100%) 2/2 (100%) 0/0 (0%)
FIRST INCIDENCE --- --- 93 (T) 93 (T) 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000 (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 51
![Page 52: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/52.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: PancreaticHemorrhage
LESION RATES
OVERALL (a) 0/0 (0%) 0/0 (0%) 1/2 (50%) 0/1 (0%) 1/2 (50%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/0.00 1/2.00 0/1.00 1/2.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 50% 0% 50% 0%
TERMINAL (d) 0/0 (0%) 0/0 (0%) 1/2 (50%) 0/1 (0%) 1/2 (50%) 0/0 (0%)
FIRST INCIDENCE --- --- 93 (T) --- 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000 (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 52
![Page 53: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/53.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: PancreaticHyperplasia Lymphoid
LESION RATES
OVERALL (a) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/1 (0%) 0/2 (0%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/0.00 0/2.00 0/1.00 0/2.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/1 (0%) 0/2 (0%) 0/0 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 53
![Page 54: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/54.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Lymph Node: PancreaticPigmentation
LESION RATES
OVERALL (a) 0/0 (0%) 0/0 (0%) 1/2 (50%) 0/1 (0%) 1/2 (50%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 0/0.00 1/2.00 0/1.00 1/2.00 0/0.00
POLY-3 PERCENT (g) 0% 0% 50% 0% 50% 0%
TERMINAL (d) 0/0 (0%) 0/0 (0%) 1/2 (50%) 0/1 (0%) 1/2 (50%) 0/0 (0%)
FIRST INCIDENCE --- --- 93 (T) --- 93 (T) ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS P=1.000 (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 54
![Page 55: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/55.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Mesentery: FatNecrosis
LESION RATES
OVERALL (a) 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%)
POLY-3 RATE (b) 0/0.00 1/1.00 0/0.00 0/0.00 0/0.00 0/0.00
POLY-3 PERCENT (g) 0% 100% 0% 0% 0% 0%
TERMINAL (d) 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%)
FIRST INCIDENCE --- 93 (T) --- --- --- ---
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) (e)
POLY 1.5 (e) (e) (e) (e) (e) (e)
POLY 6 (e) (e) (e) (e) (e) (e)
COCH-ARM / FISHERS (e) (e) (e) (e) (e) (e)
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 55
![Page 56: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/56.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Pituitary Gland: Pars DistalisCyst
LESION RATES
OVERALL (a) 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%)
POLY-3 RATE (b) 0/9.00 0/0.00 0/0.00 0/0.00 0/0.00 1/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 10%
TERMINAL (d) 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) (e) (e) P=0.521
POLY 1.5 (e) (e) (e) (e) (e) P=0.521
POLY 6 (e) (e) (e) (e) (e) P=0.521
COCH-ARM / FISHERS P=0.440 (e) (e) (e) (e) P=0.526
MAX-ISO-POLY-3 (e) (e) (e) (e) (e) P=0.178
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 56
![Page 57: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/57.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Salivary GlandsNecrosis
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/0.00 0/0.00 0/0.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- --- --- --- ---
STATISTICAL TESTS
POLY 3 (n) (n) (n) (n) (n) (n)
POLY 1.5 (n) (n) (n) (n) (n) (n)
POLY 6 (n) (n) (n) (n) (n) (n)
COCH-ARM / FISHERS (n) (n) (n) (n) (n) (n)
MAX-ISO-POLY-3 (n) (n) (n) (n) (n) (n)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 57
![Page 58: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/58.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Stomach, GlandularErosion
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 3/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 30%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) (e) (e) (e) P=0.095
POLY 1.5 P<0.001** (e) (e) (e) (e) P=0.095
POLY 6 P<0.001** (e) (e) (e) (e) P=0.095
COCH-ARM / FISHERS P<0.001** (e) (e) (e) (e) P=0.105
MAX-ISO-POLY-3 P<0.001** (e) (e) (e) (e) P=0.025*
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 58
![Page 59: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/59.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Stomach, Glandular: GlandsDilatation
LESION RATES
OVERALL (a) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 1/10.00 0/10.00 0/10.00 1/10.00 0/10.00
POLY-3 PERCENT (g) 0% 10% 0% 0% 10% 0%
TERMINAL (d) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%)
FIRST INCIDENCE --- 93 (T) --- --- 93 (T) ---
STATISTICAL TESTS
POLY 3 P=0.627N P=0.500 (e) (e) P=0.500 (e)
POLY 1.5 P=0.627N P=0.500 (e) (e) P=0.500 (e)
POLY 6 P=0.627N P=0.500 (e) (e) P=0.500 (e)
COCH-ARM / FISHERS P=0.629N P=0.500 (e) (e) P=0.500 (e)
MAX-ISO-POLY-3 P=0.270N P=0.158 (e) (e) P=0.158 (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 59
![Page 60: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/60.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
ThymusAtrophy
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 4/10 (40%)
POLY-3 RATE (b) 0/10.00 0/10.00 0/10.00 0/10.00 0/9.00 4/10.00
POLY-3 PERCENT (g) 0% 0% 0% 0% 0% 40%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 4/10 (40%)
FIRST INCIDENCE --- --- --- --- --- 93 (T)
STATISTICAL TESTS
POLY 3 P<0.001** (e) (e) (e) (e) P=0.033*
POLY 1.5 P<0.001** (e) (e) (e) (e) P=0.033*
POLY 6 P<0.001** (e) (e) (e) (e) P=0.033*
COCH-ARM / FISHERS P<0.001** (e) (e) (e) (e) P=0.043*
MAX-ISO-POLY-3 P<0.001** (e) (e) (e) (e) P=0.007**
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 60
![Page 61: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/61.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
ThymusHemorrhage
LESION RATES
OVERALL (a) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%)
POLY-3 RATE (b) 0/10.00 0/10.00 1/10.00 0/10.00 0/9.00 0/10.00
POLY-3 PERCENT (g) 0% 0% 10% 0% 0% 0%
TERMINAL (d) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) 0/9 (0%) 0/10 (0%)
FIRST INCIDENCE --- --- 93 (T) --- --- ---
STATISTICAL TESTS
POLY 3 P=0.702N (e) P=0.500 (e) (e) (e)
POLY 1.5 P=0.702N (e) P=0.500 (e) (e) (e)
POLY 6 P=0.702N (e) P=0.500 (e) (e) (e)
COCH-ARM / FISHERS P=0.704N (e) P=0.500 (e) (e) (e)
MAX-ISO-POLY-3 P=0.283N (e) P=0.158 (e) (e) (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 61
![Page 62: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/62.jpg)
DOSE 0 MG/KG 0.01 MG/KG 5 MG/KG 50 MG/KG 100 MG/KG 500 MG/KG
Thyroid Gland: FollicleHypertrophy
LESION RATES
OVERALL (a) 0/10 (0%) 0/0 (0%) 0/10 (0%) 8/10 (80%) 9/10 (90%) 10/10 (100%)
POLY-3 RATE (b) 0/10.00 0/0.00 0/10.00 8/10.00 9/10.00 10/10.00
POLY-3 PERCENT (g) 0% 0% 0% 80% 90% 100%
TERMINAL (d) 0/10 (0%) 0/0 (0%) 0/10 (0%) 8/10 (80%) 9/10 (90%) 10/10 (100%)
FIRST INCIDENCE --- --- --- 93 (T) 93 (T) 93 (T)
STATISTICAL TESTS
POLY 3 (e) (e) (e) P<0.001** P<0.001** P<0.001**
POLY 1.5 (e) (e) (e) P<0.001** P<0.001** P<0.001**
POLY 6 (e) (e) (e) P<0.001** P<0.001** P<0.001**
COCH-ARM / FISHERS P<0.001** (e) (e) P<0.001** P<0.001** P<0.001**
MAX-ISO-POLY-3 (e) (e) (e) P<0.001** P<0.001** (e)
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(F 344/N)TERMINAL SACRIFICE AT 14 WEEKS
Females
Page 62
![Page 63: P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONSMAX-ISO-POLY-3 P](https://reader033.vdocuments.us/reader033/viewer/2022051804/5fed58d56d7d4e37b86e2b7c/html5/thumbnails/63.jpg)
LEGEND
(a) Number of tumor-bearing animals/number of animals examined at site.(b) Number of tumor-bearing animals/Poly-3 number(d) Observed incidence at terminal kill.(e) Value of statistic cannot be computed.(f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group.(g) Poly-3 adjusted lifetime tumor incidence.(n) No statistics are calculated if all dose groups have fewer than two tumors.(I) Interim sacrifice(T) Terminal sacrifice# Tumor rates based on numbers of animals necropsied.* To the right of any statistical result, indicates significance at (P<=0.05).** To the right of any statistical result, indicates significance at (P<=0.01).N Indicates a negative trend for all tests
The Cochran-Armitage and Fishers exact tests compare directly the overall incidence rates.
*** END OF REPORT ***
Experiment Number: 20209 - 01 P10: STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS Date Report Requested: 07/23/2014Test Type: 90-DAY Pentabromodiphenyl oxide (technical) (DE 71) Time Report Requested: 13:31:07
Route: GAVAGE CAS Number: 32534-81-9 First Dose M/F: 07/20/04 / 07/19/04Species/Strain: RATS/F 344/N Lab: SRI
Page 63