maintain internal homeostasis. regulate body temperature maintain tissue and cellular ph
TRANSCRIPT
ToxicologyThe cardiovascular
system
The cardiovascular system
Maintain internal homeostasis. Regulate body temperature Maintain tissue and cellular pH.
Chordae Tendineae
Layers of heart
Artery Vein
Cardiac cell type
Cardiac fibroblast Vascular cells Purkinje cells Connective tissue cells Cardiac myocytes
Cardiomypathy
Cardiomypathy
Alcoholic Cardiomyopathy Peripartum Cardiomyopathy
Septal Defect: A Hole in the Heart's Wall
foramen ovale Patent Ductus Arteriosus
Electrocardiogram (ECG)
Interpreting ECG
Effects of toxicants on the cardiovascular system
There are several different injury mechanism associated with cardiac toxicants.
Generation of free redicals Lipid peroxidation Impaired membrane integrity Mitochondrial dysfunction Sarcoplasmic reticulum dysfunction Altered calcium homeostasis
Cardiotoxicants and the associated injuries
Blood toxicology
Direct and indirect damage to the hematopoietic system may produce hypoxia, hemorrhage, infection and death.
Primary hematotoxicity Secondary hematotoxicity
Toxicants-induced effects on blood
Ethanol Sideroblastic anemia
Benzene Aplastic anemia
Vinyl chloride Acquride prophyria
Nitrates Methemoglobinemia
Antimony Neutropenia
Arsine Thrombocytopenia
Methyl chloride Hemolytic anemia
Warfarin Alteration in blood clotting system
Alkylating agents Agranulocytopenia