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Page 1: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

12015.8.9. 27 1 PPA

Page 2: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO
Page 3: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

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stem cell

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Working Formulation (WF) 1982~1988

REAL 1994

WHO Jaffe ES et al 2001

/

2008 10Ver.4

Page 4: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

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Page 6: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

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Src screeningATP

ImatinibImatinib 325NEJM 354 2531-2541, 2006

Page 7: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

Kumar SK. et al. Blood 2008; 111: 2516-2520

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Page 8: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

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2001 9Pathol Int 2000;50:696-702.

Coiffier B et al. N Engl J Med 2002;346:235-24210 Blood 2010; 116:2040-2045

anti-CD20 McAb - 90Y Ibritumomab Tiuxetan

(Zevalin ) 2008

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Page 9: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

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2015 ~( )

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2010

Page 10: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

R-CHOPDay 1 2 3 4 5 6

Rituximab 375 mg/m2 (div)

CY 750 mg/m2 (div)

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PEG-G-CSF

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PEG

Metcalf D., Nature 1994;364:519

Stem Cells 16: 322-328, 1998

~70kDa

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Malignant mesothelioma

IL-6

(Plt=170 )

Higashihara M, et al: Cancer 70: 2105-2108, 1992

Page 11: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

STAT PP

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TPO

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J. Cell Biol. 147:1299, 1999

WF

ITPStandardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children:report from an international working group

---------------------------------------------------------------------------------------------Idiopathic (immune) Thrombocytopenic Purpura (ITP)

ImmunePurpura

Immune Thrombocytopenia (ITP)primarysecondary i.e. secondary ITP(lupus-associated)

lupus-associated ITP

Blood 2009;113: 2386

Page 12: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

Kurata Y, et al. Int J Hematol 93:329, 2011

2004~2007 7,774

130

56

1. 22,853

2. 9,4793. 1,192

201253:433-42, 2012

ITP

NEJM 355:1672, 2006

mpl Fc

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( )

Page 13: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

A•

Kumagai Y, et al. J Clin Pharmacol 2007;47(12):1489-97.

• Shirasugi Y, et al. Int J Hematol, 2009

• 3Miyazaki K, et al. (ASH, 2010; EHA, 2011 )Shirasugi Y, et al. Int J Hematol 2011; 2012

0.3, 1, 2μg/kg 1μg/kg

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Page 14: é L ' r · v ) · 2015-10-30 · øB6V299L !ãB2 u 2 B_B B|B B B B¨B|B B B{BpB|B B B BtB|B B @Â2nd TKI AüB B¨B|B B AýImatinibB1ABL&¿ 'B.2 -ÐB- Ó& &¿ 'BU ;B& B"BA w B BO

2. Metronidazole 500mg 2x

2010 6 18 ITP3

H.Pylori

2005 69%(300/435)63%(103/163)

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