2017symposium.research.fchampalimaud.org/wp-content/uploads/2017/09/... · champalimaud research...

CHAMPALIMAUD RESEARCH SYMPOSIUM L ISBON, 09-11 OCT. 2017

3

Invited Speakers

CNIOSpain

MariaBlasco

10 TueTalk Session 4

Alber t Eins teinCollege of MedicineUSA

PaulFrenet te


Hokkaido Univ.Japan

YasuyukiFujita

11 Wed Talk Session 7

MPI and UCLGermany, UK

Linda Par tr idge

09 MonTalk Session 3

ChampalimaudPor tugal

EduardoMoreno


iBVFrance

PierreLeopold



Univ. of V irg iniaUSA

JonathanKipnis


IMBAAustr ia

JosefPenninger

Francis Cr ick Ins t . UK

CaetanoReis e Sousa



CarlosRibeiro


09 MonKeynote Speaker

MITUSA

BobHor vitz

Francis Cr ick Ins t . UK

Jean-PaulVincent


UT SouthwesternUSA

DuojiaPan



Henrique Veiga-Fernandes


5


Lunch

m o n09

Opening remark s

Duojia Pan

Chris ta Rhiner

Jonathan K ipnis

Pierre Leopold

Raquel Ol iveira

Ri ta Sousa-Nunes

Keynote speakerBob Hor v i t z

L inda Par tr idge

Joana Neves

Ana Carmena

Cof fee Break

Cof fee Break

Poster Session 1Wine & Cheese

Regis trat ionRegis trat ion Regis trat ion

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

08:00-09:00

Programme

Talk Session

111:0

0-13:0

0

Talk Session

915:3

0-17:0

0

Talk Session

214:0

0-15:3

0

Talk Session

79:3

0-10:3

0

Talk Session

811:0

0-12:3

0

Talk Session

316:0

0-17:3

0

t u e w e d10 11

Sunset dr ink s

Banquet & Par t y

Caetano Reis e Sousa Jean-Paul V incent

Maria Blasco Yasuyuk i Fuj i ta

Bruno Costa-Si l va Valent ina Marchesin

Josef Penninger

Valer y Kr izhanovsk y A l isson Gonti jo

Rui Benedito

Cof fee Break Cof fee Break

Lunch Lunch

Closing remark s

Recept ion in amphitheatre

Boat tr ip

Poster Session 2Cof fee & Cookies

Poster Session 3Cof fee & Cookies

Poster in

Stand

s and

Spo

nso

rs Exhib

ition

14:00-15:00

21:00-22:00

11:00-12:00

17:00-18:00

09:00-10:00

08:00-09:00

15:00-16:00

22:00-23:00

12:00-13:00

18:00-19:00

10:00-11:00

16:00-17:00

13:00-14:00

20:00-21:00

19:00-20:00

Eduardo Moreno

Paul Frenet te

Haakan Norel l

Car los Ribeiro

Jorge Beira


Talk Session

49:3

0-10:3

0Talk Sessio

n 5

11:00

-12:30

Talk Session

6 15:3

0-17:0

0

7

09Registration desk opens

Keynote Lecture

m o n

Auditorium hall

Auditorium

08h00 - 09h00

09h00

UT Southwestern, USA

Champalimaud Centre for the

Unknown, Por tugal

MIT, USA

Champalimaud Foundation Board and Chairs of the 2017 Champalimaud Research Symposium

Genetic Control of Programmed Cell Death in Animal Development and Human Disease

Hippo signaling in grow th control and beyond

Activation of quiescent stem cells

Opening remarks

Bob Horvitz

Duojia Pan

Christa Rhiner

Coffee Break

Inst i tuto Gulbenkian de

Ciência, Por tugalDrosophila melanogaster brain is the l imit ing t issue in response to developmental aneuploidy

Raquel Oliveira

k

k

i

i

s

s

s

Coffee Break

Talk Session 2

Lunch Exhibition Hall

Auditorium14h00

Inst i tute of Biolog y Valrose, France

Max Planck Inst i tute for

Biolog y of Ageing , Germany

and UCL , UK

Buck Inst i tute for Research on

Aging , USA

Universit y of V irginia, USA

Inst i tuto de Neurociencias , A l icante , Spain

Immune regulation and the second brain

Coordination of organ grow th in Drosophila

Drugging ageing

MANF as an immune modulator y inter vention to improve regenerative therapies in aging

Immune and lymphatic aspects of neurological disorders

Synergism bet ween canoe and scribble mutations causes tumor- like overgrow th v ia Ras ac tivation in neural stem cells and epithelia


Pierre Leopold

Linda Par tridge

Joana Neves

Jonathan Kipnis

Ana Carmena

13h00 - 14h00

Poster Session 1

Exhibition Hall17h30


Unknown, Por tugal

i

i

s

Talk Session 3

Auditorium16h00

i

s

i

Talk Session 1

Auditorium11h00

King ’s College London, UK

In v ivo expansion of functionally integrated GABAergic interneurons by targeted increase of neural progenitors

Rita Sousa-Nuness

keynote speakerinvi ted speaker

selected speaker

9

10 t u e

Lunch12h30

Talk Session 4

Coffee Break

Auditorium09h30

Alber t Einstein College of

Medicine, USA

Centro Nacional de Invest igaciones Oncológicas , Spain

Weizmann Inst i tute of

Science, Israel

An angio-metabolic switch in prostate cancer

Telomeres as targets for cancer and aging

Accumulation of senescent cells - mechanisms and consequences

Paul Frenet te

Maria Blasco

Valery Krizhanovsky


Unknown, Por tugal

Inst i tuto de Medicina Molecular, Por tugal

Circulating exosomes as a non-invasive source of biomarkers of cancer metastatic progression

Bruno Costa-Silva

Haakan Norell

Exhibition Hall

i

s

s

s

i

Talk Session 6

Poster Session 2

Quiosque do OliveiraPríncipe Real, Lisbon

Auditorium


18h00

Francis Cr ick Inst i tute, UK


Unknown, Por tugal

Centro Nacional de Invest igaciones Cardiovasculares ,

Spain

Sensing infection and t issue damage

Fitness f ingerprints of human cells

Dual i fgMosaic: A new method to study multiple and combinatorial gene function in development and disease

Caetano Reis e Sousa

Eduardo Moreno

Sunset drinks

i

s

i

Rui Benedito

15h30

Registration desk opens

Auditorium hall08h30 - 09h30

Dissecting the dynamics of single-tumor-cell - l ineages that underpin relapse of acute myeloid leukemia

Talk Session 5

Auditorium11h00

i

s

invi ted speaker

selected speaker

1 1

11 w e d

Lunch

Reception in Amphitheatre

Boat trip

Banquet & Party

12h30

17h00

18h30

20h00

Talk Session 4

Coffee Break

Auditorium09h30


Unknown, Por tugal

Hokkaido Universit y, Japan

CEDOC, Chronic Diseases Research

Centre, Por tugal

How animals make nutrient decisions

Cell competit ion bet ween normal and transformed epithelial cells in mammals

Neuroendocrine control of morphogenesis

Carlos Ribeiro

Yasuyuki Fujita

Alisson Gontijo

Imagine Inst i tute, France

ETH Zurich, Switzer land

HNF4 inhibit ion in Drosophila nephrocy tes promotes l ipid droplet accumulation and increased sur vival under star vation.

Valentina Marchesin

Jorge Beira

Exhibition Hall

Amphitheatre

CCU Entrance

Espelho d’Água

i

s

s

s

i

Talk Session 6

Poster Session 2

Auditorium

Auditorium


16h30

Francis Cr ick Inst i tute, UK

Inst i tute of Molecular

Biotechnolog y, Austr ia

Precision Wnt signall ing

From haploid stem cells to swaying sugar trees

Jean-Paul Vincent

Josef Penninger

i

i

15h30

Integrating signall ing inputs with chromatin regulators to direct t issue regeneration or tumorigenesis

Talk Session 5

Auditorium11h00

Chairs of the 2017 Champalimaud Research Symposium

Closing words

i

s

invi ted speaker

selected speaker


1 3

09 m o n

Di ver s i t y in ant igen recogn i t ion by Unconvent iona l T ce l l s

E xosome S igna l l ing : A road map to under s t and met as t as is

Reg ula t ion of t y pe 2 innate l y mphoid ce l l s a t bar r ier s i tes

Sugar appet i te i s cont ro l led by the met abo l i c program of germl ine ce l l s

S i lenc ing the long non - coding RN A ant isense to Zeb2 fac i l i t a tes reprogramming of aged f ibrob las t s and s a feg uards s tem ce l l p lur ipotenc y.

Catarina

Bruno

Sergio

Ana Filipa

Zita

Sofia

Dina

Irina

Euclides

Inês

Patricia

Cristina

André

Yoon-Gu

1

4

7

10

13

16

19

22

25

28

31

34

37

40

Poster number

Almeida

Bernardes de Jesus

Caja Galan

Cardoso

Carvalho -Santos

Cerqueira

Coelho

Dominova

Fernandes Póvoa

Ferreira

Francisco

Godinho-Silva

Macedo

Jang

Erad ic a t ing HI V-1 fo l l i cu lar s anc tuar ies through immunotherapy

Exosomes as intermediar y of Gut-L iver communicat ion in t ype 2 diabetes

Postnatal development of g l ial GL A ST-posi t i ve cel ls

Control of innate lymphoid cel ls and enter ic defence by circadian inputs

Cull ing less f i t neurons protec ts against amyloid-β- induced brain damage and cognit ive and motor decl ine

Commensal bac ter ia and essent ial amino acids control food choice behav ior and reproduc t ion

Unravel ing the regulator y network of a complete C. elegans neural cel l l ineage

VEnCodes al low genet ic access to normal and cancer cel ls in the human body

Spat ial ac t ivat ion of TORC1 is regulated by Hedgehog and E2F1 signal ing in Drosophila eye.

At tenuat ion of synapt ic toxic i t y and MARK4/PAR1-mediated Tau phosphor y lat ion by methy lene blue for A lzheimer ’s disease treatment

Def ining the role of endothel ial notch ac t iv i t y in the biolog y of adult hematopoiet ic s tem and progenitor cel lsBone marrow ce l l s recr u i tment : p layer s a t pre -met as t a t i c n iche and met as t a t i c progres s ion

ROS-expressing neutrophils inhibi t pro-tumor IL-17-producing gamma-delta T cel ls

Cel l c ycle reentr y in the opt ic lobes of the adult Drosophila melanogaster brain

PosterSession I

Understanding the biophysical basis of teratogenesis and i t s cure: a computat ional model of developmental bioelec tr ics for repair of neuroteratorgenesis in v ivoEnaxocin ex tends l i fespan of C. elegans by inhibi t ing MIR-35-5P and mimick ing dietar y res tr ic t ion

Spliceosome subunit Salsa is required for ef f ic ient spl ic ing of gurkentranscr ipt dur ing Drosophila oogensis .

Prolac t in- induced neuroprotec t ion against g lutamate exci totoxic i t y is mediated by the reduc t ion of [Ca2+]i over load and NF-κB ac t ivat ion

Molecular chaperones in synaptogenesis and s tress

Maternal thyroid hormones def ic i t dur ing zebraf ish embr yogenesis hinders development of speci f ic cel l populat ions in the spinal cord

The Molecular and Transgenic Tools plat form at the Champalimaud Foundat ion

Def ibrot ide at tenuates oxidat ive damage of the hear t , l i ver, brain, and k idney t issues in a rat model of chronic obstruc t ive pulmonar y disease

Seongsoo

Carlos

Joana

Sofia

Shyama

Vaibhav

Silas

Om

Nadia

Elena

Nadia

Ana Raquel

Hafize

Lee

Lopez Fernandez de Castillejo

Maia

Mensurado

Nandakumar

Pai

Pinto

Rathore

Rivero

Santana Martín

Silva

Tomás

Uzun

43

46

49

52

55

58

61

64

67

70

73

76

79


1 5

10 t u e PosterSession II

T he S egment at ion C lock in Tempora l Cont ro l o f HoxB Gene E xpres s ion

T he s y s temic RN A i pathway cont ro ls longev i t y, deve lopment and fer t i l i t y in C . e legans

Neurona l reg u la t ion of t y pe 2 innate l y mphoid ce l l s v ia neuromedin U

Gl iob las toma net work dep le te neurona l wg and induces neurodegenerat ion

T he Ro le of E 78 in Met abo l i sm

Raquel

Joanna

Henrique

Vânia

Sergio

Ana Catarina

Adam

Francisco

Mafalda

Fábio

Irene

Ana

Raffaella

Malgorzata

2

5

8

11

14

17

20

23

26

29

32

35

38

41

Andrade

Bou Saab

Camara

Cardoso

Casas Tinto

Certal

Dobson

Esteves

Ferreira

Fiúza Rosa

García-González

Gonçalves

Gozzelino

Lasota

A new, eas y and re l iab le c r yopreser vat ion protoco l for zebra f i sh sperm

Programming ant igen - present ing dendr i t i c ce l l s f rom f ibrob las t s

Neura l c i rcu i t s cont ro l l ing Pro lac t in re lease dur ing sexua l behav ior

Robo/S l i t s igna l ing dur ing normal and hy pop las t i c lung deve lopment in CDH contex t : expres s ion and f unc t iona l s tud ies

Benef ic ia l and de le ter ious long- term programming of age ing and t ranscr ip t ion by ear l y - l i fe in ter vent ions

Stud y ing endothe l ia l deve lopment in zebra f i sh us ing f unc t iona l mos a ic s

Func t iona l charac ter is a t ion of tumour- der i ved exosomes in the zebra f i sh xenogra f t model

In f lammat ion - dr i ven d isr upt ion of i ron homeos t as is in Park inson ’s d isease

Prognos t ic and therapeu t ic s ign i f i c ance of the c- K I T receptor expres s ion and mu t at ion in acu te mye lo id leukemia

Deve lopment of ra t female gen i t a l cor tex and cont ro l o f female puber t y by sexua l touch

S er um of D ie t ar y Res t r i c ted Mice Dow n - Reg ula tes Ucp1 in Mur ine D i f ferent ia ted Brow n Ad ipoc y tes

Ly sosomal c y s t ine e f f lux through C T NS inac t i va tes mTOR upon fas t ing in Drosophi la

Drosophi la melanogas ter bra in i s the l imi t ing t i s sue in response to deve lopment a l aneup lo id y

Intes t ina l organo ids co - cu l tures as a nove l s y s tem to s tud y in tes t ina l l y mphoc y tes

In f lammator y IL-23 s igna ls induce de novo di f ferent ia t ion of per iphera l γδ 17 T ce l l s f rom adul t bone marrow - der i ved precur sor s

A new too l to s tud y macrophage po lar i za t ion and p las t i c i t y w i th in the tumor microenv i ronment

T he ro le of ce l l compet i t ion in Drosophi la ’ s model o f A lzhe imer ’ s D isease

T he r ight cent rosome number : How to e l iminate cent rosomes

Immunomodula tor y ro le of Kerat in 76 in ora l and gas t r i c c ancer

M A NF i s a s y s temic reg u la tor o f met abo l i c and immune homeos t as is dur ing ag ing

Is there a ro le for materna l thy ro id hormones on per ic y te recr u i tment dur ing zebra f i sh b lood -h indbra in bar r ier deve lopment?

T he g us t a tor y bas is o f prote in -spec i f i c appet i te in Drosophi la

Constanze

Raissa

Zvonimir

Mihailo

Joana F

Pedro H

Sofia

Mariana

Patrícia

Ines

Pedro

Marlene

Samuel

Lenschow

Ludwig

Marelja

Mirkovic

Neves

Papotto

Rebelo

Reis

Rodrigues

Sequeira

Sousa-Victor

Trindade

Walker

4 4

47

50

53

56

59

62

65

68

71

74

77

80

Poster number


1 7

11 w e d PosterSession III

A Func t ional Genomics approach to dissec t the pathways involved in the Mesodermal Speci f icat ion of Endothel ial and Blood Progenitor cel ls and i t s L ineage by using CRISPR Cas9

Mutat ions in ATP6AP2 are associated to congenital disorders of g lycosy lat ion with autophagic defec ts

Gamma osci l lat ions organize top-down signal ing to hypothalamus and enable food seek ing

MyT1 counterac ts the neural progenitor program to promote ver tebrate neurogenesis

Disec t ing the Anatomy of the Per iaqueduc tal Gray

Mayank

Baylor

Magda

Marta

Diogo

Andrea

Rita

Marta

Manuela

Irina

Alexandre

Ana

Anna

3

6

9

12

15

18

21

24

27

30

33

36

39

Bansal

Brangers

Cannata Serio

Carus-Cadavieco

Castro

Chai

Domingues

Estrada

Ferreira

Fonseca

Gaspar Maia

Gonçalves

Jagusiak

Spat iotemporal ly reproducible genet ic per turbat ion for ef f ic ient large-scale s tudies of non-autonomous ef fec ts

Consequences of centr iole aberrat ions in cancer

Modell ing tumor-s troma interac t ions to address disease progression and drug response mechanisms

Reveal ing the epithel ial cel ls dynamics associated with the normal and hypoplas t ic fetal lung development

Control of innate lymphoid cel ls and enter ic defence by circadian inputs

Modulat ion of enhancer ac t iv i t y in cancer and cel lular reprogramming by the his tone var iant macroH2A

Control of natural intraepithel ial l ymphoc y tes and ear ly l i fe intes t inal defence by diet-der ived ret inoids

Carbon nanotubes dispersed with supramolecular compounds as a potent ial drug del iver y sys tem - proper t ies of the complex and mechanism of the interac t ion

Understanding the role of competi t i ve interac t ions between cel ls in g l ioblas toma

T iming and reg u la t ion of cent rosome ampl i f i c a t ion in human tumor igenes is

T he ro le of Notch in coronar y ves se l format ion and remodel ing

Unrave l l ing the c i rcu i t s invo l ved in e jacu la t ion in mice

Mechanic a l s t res s - induced ce l l - c yc le modi f i c a t ion in organ propor t ion ing

V EGF R-2 s igna l ing reg u la tes the sens i t i v i t y o f acu te mye lo id leukemia to chemotherapy by reprogramming mi tochondr ia l met abo l i sm

K at 2a reg u la tes A ML se l f - renewal and cont ro ls t ranscr ip t iona l heterogenei t y in mal ignant and deve lopment a l s tem ce l l s y s tems

T he vent romedia l hy potha lamus in female mice sexua l recept i v i t y

Meningea l γδ T ce l l - der i ved IL-17 cont ro ls s y napt ic plas t i c i t y and cogn i t i ve behav iour

Zeb1 potent ia tes genome - w ide gene t ranscr ip t ion in g l iob las toma c ancer s tem ce l l s v ia a nove l Le f1-dependent mechanism

A mye lo id ce l l - cent r i c v iew of c ancer : ant i - tumour macrophages - my th or rea l i t y?

Ident i f i c a t ion of nove l hemang iob las t genes expres sed in the ear l y embr yo

Ef fec t o f er y thropoie t in pret reatment on ox idat i ve s t res s c aused by pent y lenetet razo le -induced se izures in k idney, l i ver and hear t

Katerina

Carla A.M.

Wen

Ana Rita

Kenta

Sandrina

Cristina

Inês

Julie

Pedro

Karine

Ana Teresa

Gülay

Lawlor

Lopes

Luo

Mendes

Morimoto

Nóbrega Pereira

Pina

Preguiça

Ribot

Rosmaninho

Serre

Tavares

Üzüm

42

45

48

51

54

57

60

63

66

69

72

75

78

Poster number

1 9

Symposium Sponsors

Silver Sponsors

Contributors

Institutional Support

LISBON, 09-11 OCT. 2017

Algés

Avenida da ÍndiaAvenida de Brasília

Torrede

Belém

Museu

de ArtePopular

CentroCultural de Belém

PlanetárioCalouste

Gulbenkian

Fortedo BomSucesso

Estádio do Restelo

Padrãodos

Descobrim

entos

Mosteirodos

Jerónimos

Doca Pesca

Algés

Algés - B

elém area

Belém

CH

AM

PALIM

AU

DC

EN

TRE

FOR

THE

UN

KN

OW

N

Largo da Princesa

Eléctrico 15tram

15

pedestrianroute (10 m

in.)

How

to get to the S

ymposium

Site

2017symposium.research.fchampalimaud.org/wp-content/uploads/2017/09/... · champalimaud research...

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