cell surface molecules expressed (or disappeared) during different developmental and differential...
TRANSCRIPT
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第七章 白细胞分化抗原和黏附分子
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Leukocyte Differentiation Antigen
第一节 白 细 胞 分 化 抗 原
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Leukocyte Differentiation Antigen
Cell surface molecules expressed (or disappeared) during different developmental and differential phases, activation or inactivation process of blood cells.
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LDAs on different types of cells
Endothelial cell
Tumor cells Glial cell
Neuron
Erythrocyte
Monocyte
Eosinophil
Platelets
Lymphocyte
Neutrophil Basophil
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LDA in T cell development
Fayard E. Sci. Signal. 2010
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Cluster of Differentiation
The same antigen recognized by different monoclonal antibody from different labs are called CD.
Cell
AntigenX
A B C D E
CD1xx
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ImmunophenotypingType of cell CD markers
stem cells CD34+, CD31-
all leukocyte groups CD45+
GranulocyteCD45+, CD15+, CD24+, CD114+, CD182+
MonocyteCD45+, CD14+, CD114+, CD11a, CD91+
T lymphocyte CD45+, CD3+
T helper cell CD45+, CD3+, CD4+
T regulatory cell CD4, CD25, and Foxp3
Cytotoxic T cell CD45+, CD3+, CD8+
B lymphocyteCD45+, CD19+ or CD45+, CD20+, CD24+
Thrombocyte CD45+, CD61+
Natural killer cell CD16+, CD56+, CD3-, CD31, CD30
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Adhesion Molecules 第二节 粘附分子
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Cell Movement-Chasing
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Chemokine gradient
Cell Movement-Basics
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Definition--Adhesion Molecule
Cell adhesion molecules (CAMs) are cell surface proteins involved in the interaction of cell-cell or cell-extracellular matrix.
CAMs take effect by the binding of receptor and ligand.
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Classification
Integrin familySelectin family Immunoglobulin (Ig) superfamilyCadherin family Mucin-like familyOther adhesion molecules
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I. Integrin Family
Consist of α and β chains.
According to β subunits, Integrins are divided into eight groups: β1- β8
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b1 Integrin Family
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Interaction with ECM
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b2 Integrin Family
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Integrins promote immune response
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II Selectin family
Selectins consist of one peptide chain.
The three family members include: E-selectin, L-selectin, and P-selectin.
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Structure
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Function
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Cell Recruitment Cascade
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III Immunoglobulin superfamily(IgSF)
The structure of these adhesion molecules resemble that of Ig;
CD4, CD8, CD2(LFA-2), TCR, MHC I, II molecules;
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IgSF family and their ligands
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粘附分子的功能
Cell
movement;
Cell activation.
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I. CDs in T cell activation
LFA-1ICAM-1
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II. CDs in cell movement
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CDs and AMs in Medicine第三节临床医学中的分化抗原和粘附分子
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I. Anti-CD3 Ab in transplantation
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T cell activation in transplantation
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Clinical use of humanized CD3-specific antibodies
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II. Anti-CD20 and non-Hodgkin’s lymphoma
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CD20 expression in B-cell development
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III. CD4, co-receptor for HIV
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AIDS
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The replicative cycle of HIV
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CD4/CD8 ratio
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I. Targeting Adhesion molecules on tumor cells
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Metastatic Process
Dissociation of tumor cells
Intravasation
Survival in circulation
Tumor cell proliferation at metastatic site
Extravasation
Yoon KJ Can. Biol. Ther 2009
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Cell adhesion molecules involved in breast cancer metastasis
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Drugs target CAMs
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II Blocking a4b1 integrin as therapy for MS
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Pathophysiology of MS
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α4β1 integrin in cell adhesion
Steinmen L Nat. Rev. Drugdisc 2005
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Blockade of α4β1 integrin
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Key points in the development of Natalizumab
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本章重点
名词解释: CD ;
粘附分子的定义;
粘附分子和分化抗原的功能。