© cancer research uk 2005 registered charity number 1089464 table one: numbers and rates of new...

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© Cancer Research UK 2005 Registered charity number 1089464 Table One: Numbers and rates of new cases, non-Hodgkin lymphoma, UK, 2006 England Wales Scotland N.Ireland UK Cases Males 4,751 334 437 136 5,658 Females 4,054 292 444 121 4,911 Persons 8,805 626 881 257 10,569 Crude rate per 100,000 population Males 19.1 23.1 17.7 15.9 19.1 Females 15.7 19.2 16.8 13.6 15.9 Persons 17.3 21.1 17.2 14.8 17.4 Age-standardised rate (European) per 100,000 population Males 16.4 18.2 15.0 15.6 16.3 95% CI 15.9 16.8 16.3 20.2 13.6 16.4 12.9 18.2 15.9 16.8 Females 11.6 13.0 11.9 11.2 11.7 95% CI 11.3 12.0 11.5 14.5 10.8 13.0 9.2 13.3 11.4 12.1 Persons 13.8 15.5 13.2 13.1 13.8 95% CI 13.5 14.1 14.3 16.7 12.4 14.1 11.5 14.7 13.6 14.1

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© Cancer Research UK 2005 Registered charity number 1089464

Table One: Numbers and rates of new cases, non-Hodgkin lymphoma, UK, 2006

  England Wales Scotland N.Ireland UK

Cases                    

Males 4,751 334 437 136 5,658

Females 4,054 292 444 121 4,911

Persons 8,805 626 881 257 10,569

Crude rate per 100,000 population            

Males 19.1 23.1 17.7 15.9 19.1

Females 15.7 19.2 16.8 13.6 15.9

Persons 17.3 21.1 17.2 14.8 17.4

Age-standardised rate (European) per 100,000 population    

Males 16.4 18.2 15.0 15.6 16.395% CI 15.9 16.8 16.3 20.2 13.6 16.4 12.9 18.2 15.9 16.8

Females 11.6 13.0 11.9 11.2 11.795% CI 11.3 12.0 11.5 14.5 10.8 13.0 9.2 13.3 11.4 12.1

Persons 13.8 15.5 13.2 13.1 13.895% CI 13.5 14.1 14.3 16.7 12.4 14.1 11.5 14.7 13.6 14.1

© Cancer Research UK 2005 Registered charity number 1089464

Figure One: Numbers of new cases and age specific incidence rates, by sex, non-Hodgkin lymphoma, UK 2006

© Cancer Research UK 2005 Registered charity number 1089464

Figure Two: Age-standardised incidence and mortality rates for NHL in males by region of the world, 2002 estimates

© Cancer Research UK 2005 Registered charity number 1089464

Figure Three: Age-standardised incidence rates, non-Hodgkin lymphoma, by sex, EU, 2002

© Cancer Research UK 2005 Registered charity number 1089464

Table Two: WHO Classification of NHL

B-cell

Mature B-cell lymphomasPrecursor B-cell lymphoma Small lymphocytic lymphoma

Lymphoplasmacytic lymphomaSplenic marginal zone lymphomaHairy cell leukaemiaPlasma cell neoplasms

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

Nodal marginal zone B-cell lymphoma

Follicular lymphoma (grades 1, 2, 3a and 3b)

Diffuse follicle centre lymphomaMantle cell lymphomaDiffuse large B-cell lymphoma

Mediastinal (thymic) large B-cell lymphoma

Intravascular large B-cell lymphomaPrimary effusion lymphomaBurkitt lymphoma

B-cell proliferations of uncertain malignant potential Lymphomatoid granulomatosis

Post-transplant lymphoproliferative disorder, polymorphic

© Cancer Research UK 2005 Registered charity number 1089464

Table Two (continued): WHO Classification of NHL

T-cell and NK-cellPrecursor T- and NK-cell lymphomas

Precursor T lymphoblastic lymphoma

Blastic NK-cell lymphoma

Mature T-cell and NK-cell lymphomas

T-cell prolymphocytic leukaemiaT-cell large granular lymphocytic leukaemiaAggressive NK-cell leukaemiaAdult T-cell lymphoma/leukaemiaExtranodal NK-/T-cell lymphoma, nasal typeEnteropathy-type T-cell lymphomaHepatosplenic T-cell lymphomaSubcutaneous panniculitis-like T-cell lymphomaMycosis fungoidesPeripheral T-cell lymphoma unspecifiedAngioimmunoblastic T-cell lymphomaAnaplastic large cell lymphoma

© Cancer Research UK 2005 Registered charity number 1089464

Figure Four: Age standardised (European) incidence rates, non-Hodgkin lymphoma cancer, by sex, GB, 1975-2006

© Cancer Research UK 2005 Registered charity number 1089464

Figure Five: Percentage change in age-specific incidence of NHL from 1975, persons, Great Britain

© Cancer Research UK 2005 Registered charity number 1089464

Table Three: Examples of cytogenetic/molecular abnormalities in NHL

© Cancer Research UK 2005 Registered charity number 1089464

Table Four: Primary extranodal sites for NHL

© Cancer Research UK 2005 Registered charity number 1089464

Table Five: Number of deaths and mortality rates, NHL, UK by country, 2007

  England Wales Scotland N.Ireland UKDeaths                    Males 2,047 130 225 41 2,443Females 1,730 104 213 43 2,090Persons 3,777 234 438 84 4,533Crude rate per 100,000 population            Males 8.2 8.9 9.1 4.8 8.2Females 6.7 6.8 8.0 4.8 6.7Persons 7.4 7.9 8.5 4.8 7.4Age-standardised rate (European) per 100,000 population    Males 6.5 6.5 7.1 4.4 6.5

CI 95% 6.2 6.7 5.4 7.7 6.2 8.1 3.1 5.8 6.2 6.7

Females 4.0 3.9 5.1 3.5 4.1CI 95% 3.8 4.2 3.1 4.6 4.4 5.8 2.5 4.6 3.9 4.3

Persons 5.1 5.0 5.9 3.9 5.2CI 95% 5.0 5.3 4.4 5.7 5.4 6.5 3.0 4.7 5.0 5.3

© Cancer Research UK 2005 Registered charity number 1089464

Figure Six: Number of deaths and mortality rates, NHL, UK by country, 2007

© Cancer Research UK 2005 Registered charity number 1089464

Figure Seven: One-, Five- and Ten-year relative survival for adults diagnosed with NHL in England and Wales during 1971-1995 and followed up to the end of 2001 and period survival estimates for patients alive with a diagnosis at some point during 2000-01

© Cancer Research UK 2005 Registered charity number 1089464

Figure Eight: Age-standardised relative five-year survival for men diagnosed with NHL 1990-1994, European countries