AVARX USERS GUIDE

JANUARY 2014

AvaRx is a searchable, real time database of licensing opportunities for business development professionals in the pharmaceutical industry.

The name is a shortened version of “Available Pharma products” and is pronounced “Ah-Va-Rex”.

The system is very easy to use – similar to searching for real estate online (therapeutic areas instead of neighborhoods, Phase of development instead of number of bedrooms).

AvaRx launched in January 2014 and the initial version offered access to over 1,700 business development opportunities in the pharmaceutical industry.

AvaRx is maintained by a 20-person company called Torreya Insights. This company was spun off of Torreya Partners, an investment banking firm, in 2012.

AVARX WWW.AVARX.COM

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An AvaRx search screen

AvaRx is offered to past recipients of Available Pharmaceutical Products and others on a free basis. There is a tremendous amount of high quality information available from the site at no cost.

Recipients can also obtain further information about business development opportunities listed on a subscription basis:

• Access to proprietary listings

• Access to non-confidential opportunity presentations

• Access to contact details of counterparties for specific opportunities

• Access to messaging with other subscribers Users can also add their own listings of licensing opportunities.

• It is free to include a single listing.

• Subscribers can add multiple listings and see analytics on who is reviewing their listings.

The Torreya Insights research staff is continually adding new opportunities to AvaRx and updating the opportunities that are already there.

HOW AVARX WORKS

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Simple to use AvaRx – anyone can figure it out AvaRx is open to any party that wants to search or list an opportunity at no cost AvaRx is continually being curated and subjected to quality controls

• Staff of highly educated expert adding and reviewing information

• Access to a leading advisor, Torreya Partners, enhances timelineness and quality of information

The information is of substantially higher quality than other information services that have pharmaceutical business development opportunities:

• The information is fresh

• The opportunities are actionable

• The listings have information that is relevant such as territories that are available

• Most other services have too many stale non-actionable opportunities

• Other services charge subscription fees that are often difficult to justify in light of the information available

BENEFITS OF AVARX

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Getting Started

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If you don’t have an account yet

• Go to torreya.avarx.net

• Click on “Join / Sign Up”

• Fill in your email and password.

• Your account will be created and you will be logged in automatically

• From here you can begin the process of searching available opportunities

• Or, you can set up your profile by clicking on “Account Settings” in your account.

STEP 1: GETTING AN ACCOUNT

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If you have already been assigned an account username and password then:

• Go to www.avarx.net

• Login using the box to the left of the search box

• You will get a screen like that at right.

• Click on “My AvaRx”

• Fill in your information. Key items include name, company, email, phone number and password

• Save the information

• From here you can begin the process of searching available opportunities

GETTING AN ACCOUNT CONTINUED

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As a beta user you have full access to AvaRx including:

• Access to all listings including proprietary listings and contact details

• Access to all non-confidential documents This is the access that will be accorded to a Premium Subscriber. Starting Feb 15, 2014 all beta users will be converted to Registered Subscriber. A registered subscriber gets access to all listings except proprietary listings,

documents and contact details. In other words, AvaRx is still quite useful for opportunity search and

identification as a Registered Subscriber. If you choose, you can upgrade your status to become a Premium Subscriber There are two types of Premium Subscribers:

• Premium Searchers – parties that are on the buyside and are looking to buy pharmaceutical products

• Premium Listers – parties that are on the sellside and looking to sell pharmaceutical products.

• Some parties will want to register to be both.

STEP 2: MANAGING YOUR STATUS

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Proprietary listings – There are over 300 proprietary listings only available to subscribers. These typically involve less well known BD opportunities or those that are late stage / commercial.

More information – AvaRx premium members can obtain additional information on product opportunities including access to non-confidential presentations and other documents. There are over 2,000 documents available.

AvaRx Premium members get access to contact details of a party posting a licensing opportunity.

Opportunity tracking – premium members can track opportunities and get updates.

Messaging – premium subscribers can use the messaging system to set up meetings to talk about opportunities with counterparties through AvaRx.

Premium searcher benefits

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Unlike searchers which represent the buyside, listers are on the sellside and seek to find buyers for their business development opportunity

There is no charge to become a lister and list one asset However, there are important benefits to becoming a premium

lister: Can list more than a single asset Can list undisclosed assets (use of managed

confidentiality) Can access buyside preferences and contacts through

Licensing Dynamics Can access analytics on who is viewing your listings Can send and receive messages from registered searchers

Premium lister benefits

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PRICING AND BENEFITS - SEARCHERS

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Benefits Comparison Registered User

Premium Searcher

(Single User)

Premium Searcher

(Corporate)Monthly Subscription Rate Free $795* $1995#

Number of Seats† 1 1 3

Access over 1,700 Listings P P PNumber of Undisclosed Items / Month P $3 $9

Access to Messaging P PSearch by TA, Phase of Development etc. P P PAccess Proprietary Listings P PAccess Non-Confidential Documents P PAccess Contact Information for Opportunities P PAccess to All Benefits of Being a Lister P* $8500 per annum if prepaid.* $20000 per annum if prepaid.† Pricing for large enterprise subscriptions is available upon request

PRICING AND BENEFITS - LISTERS

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Benefits Comparison Registered Free Lister

Premium Lister

Monthly Subscription Rate Free $795*

Number of Seats 1 1

Access over 1,700 Listings P PNumber of Listings 1 Up to 25

Screen Buyside Dealmakers / Get Contacts PAccess to Messaging PAccess Analytical Reports on Your Listings P* $8500 per annum if prepaid.

Finding Business Development Opportunities with AvaRx

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You can search by a number of fields:

• Therapeutic area (e.g., urology, endocrinology)

• Indication (e.g., Alzheimer’s disease)

• Development Phase (e.g., Phase I)

• Situation (e.g., Licensing Opportunity, Generic drug)

• Territories Available (e.g., Worldwide, China)

• Molecule Type (e.g., antibody)

• Route of Administration (e.g., Intravenous) You can also carry out free text searches – which

allow you to search by drug name, company name etc.

The intention is to allow you to form very specific queries such as show me all the Phase 1 urology products that have rights available for Japan.

SEARCH FIELDS

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EXAMPLE SEARCHTHERAPEUTIC AREA: AUTOIMMUNE DISEASE

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Checked the box for Autoimmune so only relevant listings are shown.

The top autoimmune indications are shown. Can see others by clicking “more”.

Clicking the red X undoes the last search

The search for autoimmune programs turned up 158 opportunities taking 16 pages. Will need to parse these further most likely.

NAVIGATING THE SEARCH RESULT PAGE

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You can refine a search by narrowing or expanding terms.

You can search by drug name

Also shown are therapeutic area, indication, phase and situation

This first opportunity from the search is a drug called C-1205

The first opportunity from the search is from a company called ConjuGon

If you “peek” you can see a brief profile.

Quick description

You can track developments for a specific opportunity. This is also a good way to bookmark.

You can refine a search by narrowing or expanding terms such as indication.

Opens up a detailed profile of the opportunity.

Clicking “more” expands the list of “Therapeutic Areas”. The list has the search item in descending order of their frequency.

The “pen” icon opens a detailed search page that allows the creation of complex compound searches.

EXAMPLE PRODUCT LISTINGCOMPANY: CUBIST PHARMACEUTICALS

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A LITTLE HISTORY

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Torreya Partners is a boutique investment bank focused on the pharma sector founded in 2007. Since being founded Torreya has become a leading player in life sciences transaction advisory with over 100 assignments successfully completed.

As a means of marketing its services, Torreya distributed a document to its customers and prospective customers for five years called “Available Pharma Products”. This is a text listing (not unlike newspaper classified ads) of pharmaceutical products available for outlicensing or M&A.

The first edition of this product was issued in 2008 and was read by less than 100 persons and had less than 500 listings.

The most recent edition of this product, issued in May 2012 was read by over 5,000 persons and had over 1,800 listings. This edition ran for over 160 pages.

Torreya customers have been asking for more frequent access to this listing, the ability to search the listings and the ability to get more information on the listings.

To meet the customer need, Torreya Partners created a new company called Torreya Insights whose main mission is to create data products and provide supporting research services.

HISTORY

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EXAMPLE ASSET LISTING IN CURRENT PRODUCT

An excerpt from Available Pharma Products, May 2012

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CUSTOMER FEEDBACK

These comments are not atypical. Business development professionals want to be able to segment the listing of available pharma products and drill down to the opportunities that are relevant to them. We have had dozens of requests like this in recent years. Many users have offered to pay for a service that would let them sort and drill down further into opportunities.

I’ve been going through this document for [my boss]. I’m trying to create a list of any opportunities that might be of interest to him. I’ve found the 160 pages a bit cumbersome. Is there any way I can get this document is a format that I could make changes more easily (delete opportunities/sort opportunities). Anything you can do would be helpful. Regards,Business Development Director, AstraZenecaMay 2012

Thank you so much for sending the Available Pharma Product list. It is invaluable to us. Could you please set it up so that I can just filter out the late stage opportunities in areas that are strategic to us? Best,Director, Strategic Transaction GroupBristol-Myers SquibbAugust 2010

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The Available Pharma Product listing is now available online (www.avarx.com) and is called AvaRx (pronounced “Ah-va-rex”).

The new version offers additional detail, not unlike the Craigslist adaptation of the classified ads.

Our mission is to provide a searchable, real time database of licensing opportunities for business development professionals in the pharmaceutical industry.

This database will continue to be offered to existing recipients of Available Pharmaceutical Products and others on a free basis. The same amount of information will continue to be available.

In addition, recipients can obtain much more information about licensing opportunities listed on a subscription basis. The additional information will non-confidential opportunity presentations and contact details of counterparties.

THE NEXT STEP: CREATION OF AVARX

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