بسم الله الرحمن الرحيمبسم الله الرحمن الرحيم

Leukocytes

•Leukopenia•Leukocytosis

Leukopenia(Agranulocytosis)

Leukopenia(Agranulocytosis)

• Myeloid stem cell suppression• Ineffective granulopoisis• Heriditary disorders, kostmann

syn.• Immune destruction• Spleenic sequestration• Peripheral destruction

• Myeloid stem cell suppression• Ineffective granulopoisis• Heriditary disorders, kostmann

syn.• Immune destruction• Spleenic sequestration• Peripheral destruction

Leukocytosis

Normal Lymph node

Lymphadenitis

• Acute nonspecific lym.

• Chronic non specific lym.– Follicular hyperplasia– Sinus histiocytosis– Paracortical hyperplasis

Neoplastic proliferation of leukocytes

–Lymphomas–Leukemias–Plasmacell dyskerasia–Langerhans cell histiocytosis

–Lymphomas–Leukemias–Plasmacell dyskerasia–Langerhans cell histiocytosis

Lymphoproliferative disorders

Lymphoproliferative disorders

• Lymphomas

• Leukemias

• Plasma cell dyscrasia

• Lymphomas

• Leukemias

• Plasma cell dyscrasia

Myeloid Neoplasms

Myeloid Neoplasms

•Acute Leukemias•Chronic Leukemias•Myelodysplastic disorders•Myeloproliferative disorders

•Acute Leukemias•Chronic Leukemias•Myelodysplastic disorders•Myeloproliferative disorders

LymphomasLymphomas

•Hodgkins lymphoma (HD)•Non Hodgkins lymphoma (NHL)

•Hodgkins lymphoma (HD)•Non Hodgkins lymphoma (NHL)

Hodgkin's Lymphoma

Non Hodgkin's lymphomaNon Hodgkin's lymphoma

LeukemiaClassification

•Acute Aml , ALL•Chronic CML , CLL

•Acute Aml , ALL•Chronic CML , CLL

Myeloblast Lymphoblast

Myeloblast Lymphoblast

• Chromatin Fine Clamp• Nucleoli 3 – 5 1- 2• Granules Variable Non• PA - +• Tdt %5 % 95• Sudan Black + - • Mpo + -

• Chromatin Fine Clamp• Nucleoli 3 – 5 1- 2• Granules Variable Non• PA - +• Tdt %5 % 95• Sudan Black + - • Mpo + -

A.M.LA.M.L

A.L.L

Myelo dysplastic syndromes

•Refractory anemia•R.A with ring sideroblast•R.A with excess blast•Chronic myelomonocytic leukemia

•RAED in trans Formation•CMML in trans Formation

Chronic myeloproliferative disorders

•CML •P.V•MMM disease•E.T

Chronic lymphoproliferative disorders

• CLL• PLL• NHL• HCL

Plasma Cell neoplasms

•Multiple myeloma•Solitary plasmacytomaWaldenstorm macroglobulinemia

•Heavy chain diseases•Primary Amiloidosis•Monoclonal Gamma pathy U.S

HistiocytosesLangerhans H /

HistiocytosisX

•Eosinophilic granuloma

•Acute disseminated H.

((Letterer – Siwe synd))

•Hand schuller chrisrian disease

Morphologic aspects

•HLA – DR•CDa•Birbeck (HX) granules