© 2015 Mayo Foundation for Medical Education and Research

Guoqian Jiang, MD, PhD1, Richard Kiefer1, Luke V. Rasmussen2; Huan Mo, MD, MS3, Jennifer A. Pacheco2, Jie Xu MS2, Enid Montague PhD2, Peter Speltz3, William K. Thompson, PhD2, Joshua C. Denny, MD, MS3, Christopher G. Chute, MD, Dr. PH4, Jyotishman Pathak, PhD1

1Mayo Clinic College of Medicine, Rochester, MN; 2Northwestern University, Chicago, IL; 3Vanderbilt University, Nashville, TN; 4Johns Hopkins University, Baltimore, MD

• Ability to propose non-breaking changes to i2b2 hive

• Most work will try to isolate hive cells and work in new cells

• Overlap with other i2b2 initiatives

• Other groups doing work in these areas?

• Fit with i2b2 roadmap?

Considerations

1. QDM: http://healthit.gov/ecqi-resource-center/qdm/index.html

2. PhEMA: http://projectphema.org

3. PhEMA Authoring Tool: http://projectphema.org:8081

4. PhEMA Data Element Repository: http://informatics.mayo.edu/phema/files/phema_rest/

5. Common Terminology Services 2: http://informatics.mayo.edu/cts2/index.php/Main_Page

6. PheKB: http://phekb.org

7. KNIME: https://www.knime.org/

8. HL7 FHIR: http://www.hl7.org/fhir/2015May/index.html

References

PhEMA Architecture i2b2 vs. PhEMA

i2b2 PhEMA Ontology

i2b2 PhEMA Integration

i2b2 KNIME Integration

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Integration of i2b2 with the Phenotype Execution and Modeling Architecture (PhEMA)

i2b2 PhEMA Cell

Proposal #1 – Quality Data Model (QDM) Cell

• How do we convert QDM-based logic to an i2b2 execution?

• Proposed solution:

• Develop a cell that converts QDM-based logic (from Library cell) to a set of i2b2 queries

• Interact with CRC to execute individual definitions

• Utilize a multi-step process, managed by the cell, for each micro-execution

• Manage translation of QDM types into i2b2 structures (mapping/configuration step)

Proposal #2 – Authoring Tool

• Can the PhEMA Authoring Tool be extended for use in i2b2?

• Proposed solution:

• Data Element Repository (DER) wrapper around Ontology cell for structure (May need to dynamically respond to metadata blobs)

• DER wrapper for allowed operations

• Common Terminology Services 2 (CTS2) wrapper around Ontology cell for terms

• Creation of i2b2 query format

Proposal #3 – PheKB Integration

• How do we connect i2b2 instances to validated, curated instances of definitions?

• Proposed solution:

• Develop a Library cell that connects to an external repository

• Web client plug-in to access and load (import?) definitions

• Requires ability to execute QDM-based logic representations & use value sets

Integration Proposals

• This work has been supported in part by funding from PhEMA (R01 GM105688), eMERGE (U01 HG006379, U01 HG006378 and U01 HG006388), and caCDE-QA (1U01CA180940-01A1).

Acknowledgements